Week 12 - Sedatives, Hypnotics and Anaesthetics Flashcards

1
Q

What are the 5 different types of Anxiety?

A
  • Generalised anxiety disorder
  • Social anxiety disorder
  • Separation anxiety
  • Specific phobia
  • Panic disorder
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2
Q

What is the cup/bucket theory?

A

more stressors add up over time

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3
Q

How do Benzodiazepines work? SEs?

A

= Allosteric modulators of GABA channels -> cause downregulation of neuronal excitability

SEs:
- drowsiness
- decreased alertness
- lack of coordination

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4
Q

How do Pregabalin work? SEs?

A

= GABA analogue that binds to a2S subunit of voltage-gated calcium channels

SEs:
- dizziness
- headache
- dairrhea

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5
Q

What is Combination Therapy?

A

Cognitive behavioural therapy
Symptomatic treatment -> drugs
Lifestyle

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6
Q

How do we measure the potency of an anaesthetic?

A

Higher the MAC, lower the potency of the anaesthetic

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7
Q

MACs of some anaesthetics

A
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8
Q

Out of Nitrous oxide, Halothane and Methoxyflurane which has the highest potency, rate of induction, and MAC?

A

Potency - Methoxflurane
Rate of Induction - Nitrous oxide
MAC - Nitrous oxide (MAC > 1000 -> also means its less potent)

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9
Q

What are some theories about the rate of induction of anaesthetics?

A

Lipid solubility:
-> high lipid solubility anaesthetics might partition themselves broadly before reaching brain (like in fat stores) -> so takes longer to be effective

Blood-gas coefficient:
-> describes the solubility of a gas in blood
-> high soluble compounds such as methoxyflurane may bind to plasma proteins and take a longer time to reach equilibrium in lungs and again with brain

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10
Q

Recovery time of anaesthetics?

A

lower potency -> faster recovery

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11
Q

What are some common anaesthetics? use?

A
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12
Q
A
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