Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Advanced Haematology > Week 12 > Flashcards

Week 12 Flashcards

1
Q

List the 3 main sources of haematopoietic stem cells

A
  1. Peripheral blood
  2. Bone marrow
  3. Umbilical cord blood
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name the 3 TYPES of haematopoietic stem cells

A

AUTOLOGOUS
ALLOGENEIC
SYNGENEIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

AUTOLOGOUS

A

→ Self

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ALLOGENEIC

A

→Genetically different donor

E.g. Sibling, Unrelated donor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

SYNGENEIC

A

→ Identical twin donor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Peripheral blood stem cell (PBSC) collection in normally collected by _________.

A

apheresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How do you increase Peripheral blood stem cell yield?

A

• Mobilise Peripheral blood stem cell with growth factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is an example of growth factors to increase Peripheral blood stem cell yield?

A

granulocyte colony stimulating factor (G-CSF)

Note: G-CSF increases number by 10 -100 times

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

List one example of an inhibitor of stem cell adhesion receptor

A

Plerixafor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do you measure the yield of harvesting?

A

Yeild is assessed by CD34+ cell count

Note: it’s generally > 2 – 4 x 106/kg CD34+ cells needed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name that cell:
is a transmembrane phosphoglycoprotein,
• first identified on hematopoietic stem and
progenitor cells

A

CD34+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the advantages of peripheral blood stem cell collection?

A

✓ Large volumes can be collected (higher than BM which mean shorter engraftment time)
✓ No anaesthesia required

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the Limitations of peripheral blood stem cell collection?

A

▪ Requires apheresis equipment

▪ Greater incidence of GvHD for allogeneic transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cord blood is rich in which cells?

A

Rich in potent haematopoietic progenitor cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

In cord blood stem cell transplant is the risk of GvHD is much lower or much higher?

A

Lower

o Greater number of HLA mismatches can be tolerated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Does cord blood have fewer or more haematopoietic progenitor cells than BM or PB harvest?

A

Fewer

17
Q

Is cord blood more useful for children’s transplant?

A

Yes

18
Q

Is the risk of risk of non-engraftment is higher or lower in cord blood transplants?

A

Higher

19
Q

Hematopoietic stem cell antigen (used as a marker)

A

CD34+

20
Q

In Autologous BMT (Mobilisation & Harvesting) What cells are collected or from where?

A

Patient’s own cells being collected

21
Q

In Allogeneic BMT (Mobilisation & Harvesting) What cells are collected or from where?

A

Donor provides peripheral blood stem cells.

22
Q

What are two types of Conditioning for Allogeneic transplants? Comment on age groups

A 
Marrow ablative (MA) - mostly younger
Reduced intensity conditioning (RIC) - can be used on older individuals
23
Q

What is the key advantage and key risk for autologous stem cell transplants?

A

Advantage - No Graft vs Host Disease

Risk - Return of malignancy

24
Q

What is the key advantage and key risk for allogeneic stem cell transplants?

A

Advantage - Graft vs malignancy effect

Risk - Graft vs Host Disease

25
Q

Major determinants of complexity for stem cell transplant?

A
  1. Donor status (Related or unrelated)
  2. Source of stem cells (BM, PB, or Cord)
  3. Acuity of patient’s underlying disease
26
Q

What are some early Complications of stem cell transplantation?

A

Infection
Haemorrhage
Acute pattern GvHD
Graft failure

27
Q

What are some late Complications of stem cell transplantation?

A 
Infection
Chronic pattern GvHD
Autoimmune disorders
Cataract
Infertility
28
Q

What are some risk factors that can lead to GvHD?

A

• Patient age
• Disease stage
• Sex mismatch with donor
(Donor T-cells recognise antigens associated with Y chromosome)

29
Q

Are infections more common in allogeneic or autologous?

A

Allogeneic

30
Q

What is the most common infection for early phase and late phase allogeneic transplants?

A

Early - bacteria

Late - viral

31
Q

In over 16yr olds is transfusion related mortality more common in autologous patients or identical sibling

A

identical sibling

32
Q

Fpr acute leukaemias when is the transplant usually performed?

A

1st or 2nd remission

33
Q

What is only potential curative treatment for MDS?

A

Allogeneic transplant

34
Q

What is the standard of care for lymphoma in many instances?

A

Autologous transplant

35
Q

HLA gene found on ______ arm of chromosome __.

A

short, 6

36
Q

What is the HLA role?

A

Present peptides to T cells so that they can recognise & eliminate foreign or non-self particles

37
Q

What does HLA stand for?

A

Human Leukocyte Antigen

38
Q

Histocompatibility testing for transplantation:
Class I antigens:
Class II antigen:

A

Class I antigens: HLA-A, B, C

Class II antigen: HLA-DR and DQ

39
Q

What administration regulates human tissue transplantation

A

Therapeutic Goods Administration (TGA)

Advanced Haematology (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions