Week 11 - Cancer Metabolism Flashcards by Samia Alam | Brainscape

Q

How does the lactate shunt work?

A

high energy demand
high glycolytic flux
NADH:NAD⁺ ratio increases
lactate shunt regenerates NAD⁺
allows glycolysis to continue
inefficient but quick method to produce ATP very quickly

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Q

What is the Warburg effect?

A

cancer cells use the lactate shunt despite a high oxygen availability

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Q

How is targeting the Warburg effect therapeutic?

A

inhibiting MCT channel
intracellular accumulation of lactic acid
drop in pH
cell death
only targets cells using lactate shunt

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Q

What is synthetic lethality?

A

when a combination of two events results in cell death
e.g. presence of FH and haemophilia inhibition

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