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Nurp 423 Exam 3 > Week 11 > Flashcards

Week 11 Flashcards

1
Q

SSRI plus partial antagonist of 5-HT1A receptor:

A

Viibryd

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2
Q

Examples of SNRIs:

A

Effexor (venlafaxine)
Cymbalta (duloxetine)
Savella (milnacipran)

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3
Q

What SNRI is also used for hot flashes, menopause in women who cannot take hormones?

A

Effexor(venlafaxine)

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4
Q

Example of tricyclics:

A

Elavil (amitriptyline)

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5
Q

Example if MAOI:

A

Nardil (phenelzine)

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6
Q

Examples of serotonin receptors antagonists:

A

Remeron (mirtazapine)

Oleptro (trazadone)

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7
Q

Wellbutrin is an:

A

Aminoketone

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8
Q

Abilify (aripiprazole) is an:

A

Atypical antipsychotic that can be used for refractory depression or bipolar depression.

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9
Q

SSRIs MOA:

A

Potently and selectively inhibit serotonin uptake on presynaptic neuron which increases concentration of 5HT in synapse by inhibiting reuptake.

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10
Q

SSRIs are indicated for:

A

Frequently 1st choice for depression
Used with anxiety
Very useful in OCD

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11
Q

Examples of SSRIs:

A 
Zoloft (sertraline)
Paxil (paroxetine)
Celexa (citalopram)
Lexapro (escitalopram)
Luvox (fluvoxamine)
Prozac (fluoxetine)-oldest with longest half-life
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12
Q

What SSRI do you not need to taper off?

A

Prozac due to long half-life

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13
Q

SSRI with shortest half-life?

A

Luvox (fluvoxamine)

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14
Q

How long for SSRI to reach full therapeutic strength?

A

2 weeks

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15
Q

Side effects of SSRIs:

A

Nausea, loose stools
Sexual dysfunction
Weight gain
Black box: suicidal ideation

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16
Q

Symptoms of serotonin syndrome:

A 
Rigidity
Hyperthermia
Autonomic instability
Tremors
Confusion
Delirium
Coma
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17
Q

Causes of serotonin syndrome:

A

Interaction of SSRI with cardiac meds
Dosage too high
Interaction with MAOIs
Interaction with St. John’s Wart

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18
Q

SSRI withdrawal syndrome symptoms:

A 
Flu-like
Lightheadedness 
Uneasiness or restlessness 
Sleepiness or sensory disturbances
Headaches
19
Q

Short acting benzodiazepines:

A

Ativan, Xanax, Serax

20
Q

Long acting benzodiazepines:

A

Klonopin

Librium

21
Q

Longest half life of the benzodiazepines:

A

Valium

22
Q

MOA of benzodiazepines:

A

Bind to molecular components of GABA receptors in the CNS’s neuronal membranes. Potential GABA-ergic inhibition at all levels of CNS which decreases the firing rate of critical neurons

23
Q

Benzodiazepines metabolized in:

A

Liver

24
Q

Side effects of benzodiazepines:

A

Sedation
Respiratory depression
Increased tolerance/physiologic dependence

25
Q

Benzodiazepine antagonist:

A

Romazicon delivered IV

26
Q

Serotonergic Agonist:

A

Buspirone (Buspar)

27
Q

Buspirone is used in treatment of:

A

Anxiety (no effect of GABA system so do not use in benzodiazepine withdrawal)

28
Q

Side effects of buspirone:

A 
Dry mouth
Lightheadedness
Headache
Insomnia
Interaction with maois or SSRIs May potentiate serotonin syndrome
29
Q

ADHD diagnostic criteria:

A 
Consistent through time 
More than one setting 
Existed before 12
Clear impairment of functioning 
No longer disqualified by comorbid diagnosis
30
Q

First line treatment of adhd:

A

Stimulants: adderral(amphetamine/dexamphetamine) or Ritalin (methylphenidate)

31
Q

Contraindications of stimulants:

A

History of schizophrenia or other psychosis

Symptoms of anxiety, tension, and agitation

32
Q

Side effects of stimulants:

A 
Decreased appetite 
Delayed onset of sleep 
Rare: 
Growth deceleration
Blood dyscrasias (CBC once/twice a year)
Mood changes
Hallucinations
33
Q

First line nonstimulant medication for adhd:

A

Strattera (atomoxetine)

34
Q

Strattera is a:

A

Noradrenergic reuptake inhibitor- increases norepinephrine

35
Q

Strattera is not to be used:

A

With glaucoma or MAOIs or concurrently with albuterol

36
Q

Side effects of strattera:

A 
Suicidal ideation 
Liver damage
Effect not always immediate 
GI upset
Decreased appetite
Mood swings 
BP increase
37
Q

Clonidine is an:

A

Alpha-2 agonist- good mood stabilizer, capable of controlling tics and hyperactivity

38
Q

Side effects of clonidine:

A

Hypotension
Dry mouth
Oversedation
Rebound hypertension is stopped abruptly

39
Q

Guanfacine is an:

A

Alpha-2 agonist that is less sedation than clonidine and the only antihypertensive agent approved for ADHD

40
Q

What antidepressants are food for patients with somnolence?

A

Fluoxetine (Prozac) and sertraline (Zoloft)

41
Q

What antidepressant is good for patients with insomnia:

A

Paroxetine(Paxil)

42
Q

Second line therapy in depression:

A

TCA- nortriptyline or desipramine

43
Q

First line therapy for GAD:

A

SSRI or SNRI

44
Q

Second line for GAD:

A

Buspirone or imipramine

Nurp 423 Exam 3 (3 decks)

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