Week 1 - Topic 2 Flashcards
What does disease burden mean
Measure of morbidity and mortality
What is the disease burden of neuropsychiatric disorders - worldwide and for the EU?
WW 28% of which 2% BPD and 10% MDD
Surpasses Cancer (11%)
EU 33.4 Million people, and a cost of 113 Billion GBP
What are phases of BDP
Mania, Hypomania, Depression, Maintenance
Also - subsyndromal depression, which lasts longer time.
What are comorbidities of BDP
Substance and alcohol abuse, anxiety and it affects 75% of BDP
What are mixed cases in BDP and are they common
Yes, they are common. They present both mania and depression, at the same time.
What is the level of reliability in the diagnosis of BDP and MDD?
BDP I is more reliable than BDP II, and both are more reliable than MDD.
Reason: manic episodes are a strong symptom in BDP I characterization and diagnosis.
Describe onset, lifetime risk, and severity of BDP
Merikangas 2007
- Onset at younger age, before 25 years of age.
- Lifetime risk for BDP I is 1%
- Lifetime risk for BDP II is 1.1%
- Lifetime risk for subthreshold depression is 2.4%
- Severe episodes over 12 months: BDP I is 75% |BDP II is 69%
- Comorbidities: 75% of BDP have psychiatric comorbidities
Age of onset for BDP
More common and less common
0-10 very low.
12-25 frequent.
25-50 another climb in the curve.
50+ plateau.
Usually 1-2 depressive episodes appear before mania.
Kreppelin model of mixed states of BDP
Pure Mania vs Pure Depression
Within:
1. Depressed anxious
2. Excited depression
3. Manic thoughts poverty
4. Manic stupor
4. Depressed with flight of ideas
5. Inhibited mania (low energy)
Mixed states: presence of mania and depression at the same time.
Associations of BDP with comorbidities
Mania associated to substance abuse.
Depression associated with severe functional impairment.
