Week 1 - Neuro Drugs

Question 1

acetazolamide (Diamox)

Answer 1

reduces CSF in cases of hydrocephalus, inhibits carbonic anhydrase, first choice to decrease production of CSF

Question 2

quabain

Answer 2

reduces CSF in cases of hydrocephalus, Na/K ATPase inhibitor

Question 3

furosemide

Answer 3

reduces CSF in cases of hydrocephalus, inhibits Na/K transporter

Question 4

chondroitinase

Answer 4

enzyme, degrades chondroitin sulfate proteoglycan (CSPG) - an inhibitor released by glial scar (astrocytes), promotes CNS plasticity

Question 5

mannitol

Answer 5

treatment for cerebral edema, osmotic diuretic in blood, small sugar, 1-2g/kg, reduces CSF alread made - does not stop making or more CSF

Question 6

surgery or shunt

Answer 6

treatment for hydrocephalus, reduces CSF and pressure

Question 7

prednisone

Answer 7

given for MS (among other things), corticosteroid that reduces inflammation by decreasing amount of immune cell migration into CNS, prevents arachadonic acid release by phospholipase 2 (PLA2) which

Question 8

methylprednisolone

Answer 8

given for MS, decreases expression of adhesion molecules VLA-4 and LFA-1

Question 9

interferon B 1a (avonex)

Answer 9

given for MS, natural human protein made with genetic recombination, slows progression of MS, reduces MS relapses, believed to repair holes in blood-brain barrier, reduces antigen presenting, reduces T cell proliferation, alters cytokine expression, and restores suppressor function