Week 1 - Introduction

Question 1

• protects public safety
• ensure safety efficiency

Answer 1

Food Drug Admin (FDA)

Question 2

• regulate manufacture and distribution of controlled substances (harmful effect that needs high supervision)
• class 1 (street drugs) to class 5 (low potential for abuse)
• investigate criminal and drug gangs that traffic illegal drugs

Answer 2

Drug Enforcement Admin (DEA)

Question 3

Pharmacokinetics

Answer 3

1. absorption
2. distribution
3. metabolism
4. excretion

Question 4

transport from administration site to bloodstream; depending on route of admin

Answer 4

Absoprtion

Question 5

transport to site of action by bodily fluids

Answer 5

Distribution

Question 6

biotransformation into less active/inactive forms; mainly by the LIVER

Answer 6

Metabolism

Question 7

elimination from the body; primary from KIDNEY

Answer 7

Excretion

Question 8

• varies with meds and route
• highest concentration; if too much = toxic

Answer 8

Peak

Question 9

• immediately prior to next dose
• lowest concentration; if too low = no effective

Answer 9

Trough

Question 10

1 goal for American drug laws (FDA and DEA)

Answer 10

Patient safety

Question 11

body weight, age, gender, genetics, biorhythmic cycles, tolerance, accumulation, psychological factors, nutrition, medical problems, pregnancy/lactation/reproduction

Answer 11

Variables affecting mechanism of action or Affects pharmacokinetics

Question 12

range between the peak and trough

Answer 12

therapeutic index

Question 13

half time it takes for body to metabolize, excrete

Answer 13

t1/2

Question 14

• polypharmacy
• hydration, illness
• don’t have good metabolism > slows mechanism of actions

Answer 14

Adverse Reaction for elderly patients

Question 15

• use of FDA approved meds, but used inappropriately
• ex. label says to use daily but provider order to use BID
• ex. sildenafil

Answer 15

Off Label meds