Week 1 - DRV & Alcohol Flashcards

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1
Q

EAR

A

estimated average requirement

meet 50% of the whole population - assuming normal distribution

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2
Q

LRNI

A

Lower reference nutrient intake - 2 SD below from the normal, meet 2.5% of the whole populations needs

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3
Q

RNI

A

reference nutrient intake - 2 SD above the normal and meets 97.5% of the whole populations needs

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4
Q

Nutrient - macro/micro

A

Nutrient is something that gives essential nourishment to function
macro - carb, protein, fat, alcohol
micro - vitamins & minerals

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5
Q

nutrient requirement equation

A

nutrient requirement = metabolic demand / efficiency

* not everyone has the same

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6
Q

Safe intake

A

Intake considered fine for most people but not too high that could cause adverse effects

Used for nutrients/minerals where there is insufficient information

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7
Q

DRV - important notes

A

Dietary reference value

  • apply to healthy people
  • doesn’t apply to those with disease or metabolic abnormalities
  • assumes all other nutrient requirements are met
  • knows that not 100% of nutrient gets absorbed (exception made for Iron, this is accounted for)
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8
Q

Data to determine DRV’s

A
  1. Observational - look at populations with deficiency or excess
  2. Balance studies - intakes known and match losses
  3. Physiological estimates - to meet needs of growth tissue e.g. milk production in lactate breastfeeding
  4. Functional studies - intake associated with optimal functioning
  5. Clinical studies - e.g. how to cure vitamin D deficiency
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9
Q

Defining adequacy

A
  • Have safe upper limits
  • Prevent deficiency
  • Optimise body stores
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10
Q

DRV - Protein

A

EAR - 0.6g per kg of body weight per day
RNI - 0.75g per kg of body weight per day

  • more required for infants, children, pregnant and breast feeding women
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11
Q

DRV - Energy

A

Derived from fat, carb, protein and (alcohol)

EAR - assumes normal distribution, 50% of population will require less, and 50% will require more

  • Assumes intake matches appetite, based on total energy expenditure (TEE)
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12
Q

Total energy expenditure (TEE)

A

= basal metabolic rate (BMR) x physical activity levels (PAL)

– females 19-50y EAR = 8.1 MJ /1940 kcal
[Based on 60kg & PAL = 1.4 (inactive)]

– males 19-50y EAR = 10.6 MJ /2550 kcal
[Based on 74kg & PAL = 1.4 (inactive)]

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13
Q

DRV - Fat/ Carbs/ Sugars

A

Not DRVs set - no known deficiencies or toxicities

There are some essential fatty acids

Assumes 5% energy comes from alcohol

Assumes 15% comes from protein

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14
Q

DRV limitations

A
Limited to certain groups .e.g Men
Some groups we don't know much about e.g. Children
Data errors e.g self-reported data
Some nutrients there is little known
Needs to be updated 10-15yrs
Requirements are only a best guess
Safety margins can vary across countries
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15
Q

Ethanol

A
  • Structurally like carb
  • metabolically like fatty acid
  • High energy content
  • ‘Empty calories’ because no nutrients except folate in beer
  • Not essential because no essential nutrients
  • In UK it’s assumed that 5% energy comes from alcohol
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16
Q

Alcohol upper limits

A
  • Max 14 units / week
  • If drinking max units, spread over 3 days
  • Risk of cancers, increases the more regularly you drink
  • 1 unit = 10ml/8g of alcohol
17
Q

Alcohol - pregnant women

A
  • Advice is: no alcohol

- Risk of fetal alcohol syndrome with mental and physical defects and long term issues

18
Q

Typical alcohol units

A

Spirit 40%: 25 ml = 1 unit

White wine 11-14%:
125ml (1.5 units)
250 ml (3 units)
750ml bottle (9-10 units)

Red wine: 12-15% slightly more than above

Beer 4-8%
1 pint 569ml = 2.3-4.5 units

19
Q

Absorption & metabolisation of alcohol

A
  1. Absorbed by GI tract - peak concentration in the bloodstream in 20-60 mins
  2. Transported by blood
  3. Metabolized in the liver by either
    a) Alcohol dehydrogenase pathway
    b) Cytochrome p450 system
20
Q

AHD (alcohol dehydrogenase) pathway

A

Breaking down of alcohol

  1. ADH metabolises alcohol into acetaldehyde dehydrogenase (toxic)
  2. Acetaldehyde is further broken down into acetate
  3. Ends with carbon dioxide + H2O for easy elimination
  • Oxidation: Generates NADH at the expense of NAD+, promotes fatty liver and lactic acidosis
  • Acetaldehyde: impairs protein function and causes cirrhosis
21
Q

Cytochrome p-450 system

A

Also known as MEOS (microsomal ethanol oxidising system)

  • Occurs in chronic alcoholism
  • Ethanol gets oxidised
22
Q

Alcohol related liver diseases

A
  • fatty liver disease
  • cirrhosis
  • metabolic tolerance
  • lactic acidosis
23
Q

Metabolic Tolerance

A

Heavy drinkers can become tolerant b/c of metabolic adaptions

  • ADH also converts vitamin A into retinal (for vision).
    Chronic alcohol consumption reduces retinal = worse vision
24
Q

Other adverse effects of alchol

A
  • mental health
  • injury risk
  • Liver, breast, colon, oral, pharyngeal, laryngeal, oesophagal cancer (some cancers have mixed research but upper GI tract cancer shows correlation)
  • stroke risk