Week 1 - Diabetes Flashcards
Define diabetes mellitus.
A group of metabolic diseases in which an individual has hyperglycemia for one of two reasons. Either the pancreas does not produce enough insulin (absolute deficiency) or the cells do not adequately respond to the insulin which is produced (relative deficiency).
List 4 potential symptoms of diabetes mellitus.
Polydipsia, Polyuria, Glycosuria, and blurred vision.
What are three diagnostic characteristics which can be used to diagnose a patient with diabetes mellitus?
Fasting glucose > 7.0 mmol/L
Random glucose >11.1mmol/L
HbA(Ic) > 6.5%
What is pre-diabetes an associated risk factor of?
Development of diabetes and macrovascular disease.
What recurrent infection can be diagnostic of diabetes mellitus?
Recurrent Candida infection, especially in men who otherwise get very few yeast infections.
List two major differences between Type I & Type II diabetes mellitus.
Type I: Weight loss & autoimmune disease.
Type II: Associated with obesity & insensitivity to insulin.
What route does insulin take to be activated, what enzymes are involved in this action, and how is endogenous insulin production measured?
Pre-Proinsulin –{Prohormone convertase}–> Proinsulin –{Carboxypeptidase}–> Insulin.
Peptide C is a by product of this conversion. For every endogenously derived insulin TWO Peptide C are generated as well.
List the three insulin sensitive tissues.
Liver, Adipose, and Muscle {LAM}.
With tight control of blood glucose concentration retinopathy will be _______ for the first two years and ______ in the long run.
Worse, Better
What does laser photocoagulation (PPR) target?
Ischemic regions of the retina which release angiogenesis stimulation growth factors. {This type of treatment DOES NOT target the invading blood vessels themselves.}
What factor (other than blood glucose concentration) is very beneficial to have tightly regulated in avoiding retinopathy?
Blood Pressure
What percentage (of all dialysis patients) start dialysis because of diabetic neuropathy?
50%
What are 3 clinical characteristics of nephropathy?
Albuminuria, Hypertension, and progressive decline in renal function.
List 5 factors which may influence the development of diabetic retinopathy:
- Blood Pressure
- Blood glucose concentration.
- RAS (Renin-Angiotensin System).
- Lipids
- Smoking
What percentage of diabetic patients develop neuropathy? What is the most common way for this to present clinically?
60% - 70% {Ranging from insignificant to severe}.
Foot ulcers.
Diabetic peripheral neuropathy may present through . . .
Cranial nerve palsies, numbness, or extreme sensitivity/pain.
Describe neuropathic foot ulcers. {Other type: Ischemic}
- Pressure is associated with calluses.
- Ulcers are painless.
- On the plantar surface of the foot.
- The feet are warm with dilated veins.
Describe ischemic foot ulcers. {Other type: Neuropathic}
- On the dorsal or lateral surfaces of the foot.
- Ulcers are painful.
- Appear “punched out”.
- The feet are cold, pale, and pulseless.
What is a charcot foot a result of? What is it a major risk factor for?
Peripheral neuropathy, Ulceration.
Charcot’s arthropathy involves bone reabsorption and degeneration of a weight bearing joint. Onset is often insidious. May result in ulceration, super infections, or amputation.
What will 70% - 80% of patients with diabetes die from?
Cardiovascular Disease {Macrovascular Disease}.
What is CAD?
Coronary Artery Disease
What disease is predicted by T2DM diagnosis?
Coronary Artery Disease (CAD)
What disease is predicted by T1DM?
Diabetic Nephropathy & Diabetic Retinopathy
What percentage of diabetes patients are blind?
< 1%. Half of those that are blind have blindness caused by factors other than diabetes.
What cell is damaged and lost in diabetic retinopathy?
Pericytes - Contractile cells which wrap around the endothelial cells of capillaries and venules throughout the body.
What are “cotton wool spots”?
Ischemic nerve fibres of the eye. These nerve fibres are translucent in healthy individuals but become opaque after the swelling and bloating caused by ischemia.
What causes hemorrhages in the vitreous humour?
After ischemia occurs growth factors are released which stimulate angiogenesis. These new blood vessels are weak and grow into the vitreous humour. Eventually they hemorrhage or aneurism.
These vessels may also scar and contract causing retinal detachment.
What hormone may be related to the development of retinopathy?
Growth Hormone (GH)
Which type of diabetes is retinopathy more common in?
T1DM {Nearly 100% of people with T1DM will develop some degree of retinopathy after having the disease for >10 years}.
What do the beta cells of the Islets of Langerhans produce?
Insulin
What do the alpha cells of the Islets of Langerhans produce?
Glucagon
What do the delta cells of the Islets of Langerhans produce?
Somatostatin
What do the PP cells of the Islets of Langerhans produce?
Pancreatic Polypeptide
What exocrine secretions does the pancreas produce?
Digestive enzymes.
How many unit of insulin should a resting person inject if they have eaten 20g worth of carbs?
4 units, assuming they started with an acceptable [glucose] in their blood.
1 unit of insulin / 5 grams of carbs
What is the target HbA(1c) for patients with diabetes?
7%
Insulin (and its analogs) likes to form _______ but must form _______ and _______ to enter the blood.
Hexamer, Dimer, Monomers.
What is a typical maximum total daily dose of insulin for a patient for T1DM?
1 unit/kg/day.
40% - 50% Basal {Long acting}.
50% - 60% Bolus {With meals}.