Week 1 Flashcards
What are the phases of wound healing?
- Inflammation
- Proliferation
- Maturation/re-modeling
What are the types of responses we get in the inflammation phase of healing?
- Vascular response
- Cellular response
What is the goal of the vascular response of the inflammation phase of healing?
Control bleeding, fight infectious agents
What are the events that occur during the vascular response of the inflammation phase of healing?
- Transudate leaks out of vessel walls: local edema
- Local blood vessels reflexively constrict
- Platelets aggregate and are activated: forms a plug to wall off affected area and closes off lymphatic channels creating more edema, release chemical mediators necessary for wound healing
- Within 30 minutes of vasoconstriction, vasodilation occurs: localized redness, warmth, edema
What are the cardinal signs of the vascular response of the inflammation phase of healing?
Edema, redness, warmth, pain, decreased function
What are the events that occur during the cellular response of the inflammation phase of healing?
• Increased leakiness of vessel walls: pushes polymorphonuclearneutrophils (PMNs) to sides of vessel walls
(Margination)
- PMNs: 1st to site of injury (12-24 hours), kill bacteria, clean
wound, secrete matrix metalloproteases (MMPs)- degrade debris
• Macrophages arrive: kill pathogens, direct the repair process
• Mast cells: produce histamine and secrete enzymes to accelerate
riddance of damaged cells
What are the key cells present in the cellular response of the inflammation phase of healing?
- Platelets
- PMNs
- Macrophages
- Mast cells
What are the events that occur during the proliferation phase of healing?
• Angiogenesis- formation of new blood vessels
• Granulation tissue- Fibroblasts lay down extracellular matrix
(eventually replaced by scar tissue)
• Wound Contraction – myofibroblasts pull wound margins
together
• Epithelialization- keratinocytes and epidermal appendages
multiply and migrate across wound bed
What are the key cells present in the proliferation phase of healing?
- Angioblast
- Fibroblast
- Myofibroblast
- Keratinocyte
What are the events that occur during the maturation phase of healing?
• Granulation tissue must be strengthened and reorganized
• Rapid collagen synthesis
• Up to 2 years following wound closure
- Greatest change in first 6-12 months
• 80% of full tissue strength
• Unable to sweat- loss of sweat glands
• Less sensitive to touch and temperature
What are the type of factors that can affect wound healing?
- General
- Local
- Clinician
- Systemic
What are the general factors that can affect wound healing?
• Mechanism of Onset • Time since onset – Acute vs Chronic • Location- consider blood supply, bony prominences, typical skin thickness • Wound Dimensions- Circular is slower than square or rectangle is slower than linear • Temperature (37-38 degrees C is best) • Wound Hydration • Necrotic tissue • Infection
What are the local factors that can affect wound healing?
- Circulation
- Sensation
- Mechanical Stress
What are the circulation local factors that can affect wound healing?
- Macro(checking pulses) and Micro
* Sympathetic nervous system responses to: cold, fear, and pain
What are the sensation local factors that can affect wound healing?
- Decreased knowledge of pain
* Additional trauma to area
What are the mechanical stress local factors that can affect wound healing?
- Friction
- Shear
- Weight bearing
- Pressure
What are the systemic factors that can affect wound healing?
- Age: normal physiologic changes
- Nutrition
- Comorbidities
- Medications
- Behavioral Risk Taking
What are the “age” systemic factors that can affect wound healing?
- Slowed immune response
- Decreased collagen synthesis
- Epidermal and dermal atrophy (thinner skin)
- Less sweat and oil glands (dryer skin)
- Decreased pain perception
- Decreased inflammatory response
- More co-morbidities
- More susceptible to infection
- More medications
What are the “nutrition” systemic factors that can affect wound healing?
- Carbohydrates for energy
* Protein for cellular repair/regeneration (most imp)
What are the “comorbidities” systemic factors that can affect wound healing?
• Those affecting O2 perfusion - PVD, anemia, COPD, heart conditions • Immunocompromised - HIV/AIDS, diabetes • Activity limitations
What are the “medications” systemic factors that can affect wound healing?
- Steroids
- Chemotherapy
- NSAIDS
What are the “behavioral risk taking” systemic factors that can affect wound healing?
- Smoking
* ETOH
What are the clinician induced factors that can affect wound healing?
- Inappropriate Wound Care
* Appropriate Wound Care
What are the “inappropriate wound care” clinician induced factors that can affect wound healing?
- Prolonged or inappropriate use of antiseptics
- Wrong dressing selection (macerates or dries out)
- Failure to detect/treat infection
- Inappropriate irrigation, debridement, compression, etc.
- Poor wound exploration
- Poor temperature management