Week 1 Flashcards
What are the phases of wound healing?
- Inflammation
- Proliferation
- Maturation/re-modeling
What are the types of responses we get in the inflammation phase of healing?
- Vascular response
- Cellular response
What is the goal of the vascular response of the inflammation phase of healing?
Control bleeding, fight infectious agents
What are the events that occur during the vascular response of the inflammation phase of healing?
- Transudate leaks out of vessel walls: local edema
- Local blood vessels reflexively constrict
- Platelets aggregate and are activated: forms a plug to wall off affected area and closes off lymphatic channels creating more edema, release chemical mediators necessary for wound healing
- Within 30 minutes of vasoconstriction, vasodilation occurs: localized redness, warmth, edema
What are the cardinal signs of the vascular response of the inflammation phase of healing?
Edema, redness, warmth, pain, decreased function
What are the events that occur during the cellular response of the inflammation phase of healing?
• Increased leakiness of vessel walls: pushes polymorphonuclearneutrophils (PMNs) to sides of vessel walls
(Margination)
- PMNs: 1st to site of injury (12-24 hours), kill bacteria, clean
wound, secrete matrix metalloproteases (MMPs)- degrade debris
• Macrophages arrive: kill pathogens, direct the repair process
• Mast cells: produce histamine and secrete enzymes to accelerate
riddance of damaged cells
What are the key cells present in the cellular response of the inflammation phase of healing?
- Platelets
- PMNs
- Macrophages
- Mast cells
What are the events that occur during the proliferation phase of healing?
• Angiogenesis- formation of new blood vessels
• Granulation tissue- Fibroblasts lay down extracellular matrix
(eventually replaced by scar tissue)
• Wound Contraction – myofibroblasts pull wound margins
together
• Epithelialization- keratinocytes and epidermal appendages
multiply and migrate across wound bed
What are the key cells present in the proliferation phase of healing?
- Angioblast
- Fibroblast
- Myofibroblast
- Keratinocyte
What are the events that occur during the maturation phase of healing?
• Granulation tissue must be strengthened and reorganized
• Rapid collagen synthesis
• Up to 2 years following wound closure
- Greatest change in first 6-12 months
• 80% of full tissue strength
• Unable to sweat- loss of sweat glands
• Less sensitive to touch and temperature
What are the type of factors that can affect wound healing?
- General
- Local
- Clinician
- Systemic
What are the general factors that can affect wound healing?
• Mechanism of Onset • Time since onset – Acute vs Chronic • Location- consider blood supply, bony prominences, typical skin thickness • Wound Dimensions- Circular is slower than square or rectangle is slower than linear • Temperature (37-38 degrees C is best) • Wound Hydration • Necrotic tissue • Infection
What are the local factors that can affect wound healing?
- Circulation
- Sensation
- Mechanical Stress
What are the circulation local factors that can affect wound healing?
- Macro(checking pulses) and Micro
* Sympathetic nervous system responses to: cold, fear, and pain
What are the sensation local factors that can affect wound healing?
- Decreased knowledge of pain
* Additional trauma to area
What are the mechanical stress local factors that can affect wound healing?
- Friction
- Shear
- Weight bearing
- Pressure
What are the systemic factors that can affect wound healing?
- Age: normal physiologic changes
- Nutrition
- Comorbidities
- Medications
- Behavioral Risk Taking
What are the “age” systemic factors that can affect wound healing?
- Slowed immune response
- Decreased collagen synthesis
- Epidermal and dermal atrophy (thinner skin)
- Less sweat and oil glands (dryer skin)
- Decreased pain perception
- Decreased inflammatory response
- More co-morbidities
- More susceptible to infection
- More medications
What are the “nutrition” systemic factors that can affect wound healing?
- Carbohydrates for energy
* Protein for cellular repair/regeneration (most imp)
What are the “comorbidities” systemic factors that can affect wound healing?
• Those affecting O2 perfusion - PVD, anemia, COPD, heart conditions • Immunocompromised - HIV/AIDS, diabetes • Activity limitations
What are the “medications” systemic factors that can affect wound healing?
- Steroids
- Chemotherapy
- NSAIDS
What are the “behavioral risk taking” systemic factors that can affect wound healing?
- Smoking
* ETOH
What are the clinician induced factors that can affect wound healing?
- Inappropriate Wound Care
* Appropriate Wound Care
What are the “inappropriate wound care” clinician induced factors that can affect wound healing?
- Prolonged or inappropriate use of antiseptics
- Wrong dressing selection (macerates or dries out)
- Failure to detect/treat infection
- Inappropriate irrigation, debridement, compression, etc.
- Poor wound exploration
- Poor temperature management
What are the “appropriate wound care” clinician induced factors that can affect wound healing?
- Initial use of antiseptics to kill everything
- Maintenance care when wound healing is not priority
- Use of iodine to encourage/maintain non-viable tissue desiccation
What are the types of wound closure?
- Primary (Primary Intention)
* Secondary (Secondary Intention)
What are the events of primary wound closure?
- Wound edges are approximated without/little formation of granulation tissue.
- Not typically seen by PT unless preparing for delayed primary closure
What are the events of secondary wound closure?
- Wound edges unable to be approximated
- Granulation tissue fills in wound bed
- PT more likely to be involved
What are the benefits of moist wound healing?
• Enhance wound healing and promote new tissue growth
• Low moisture levels… lead to necrosis and eschar formation,
hindering wound re-epithelialization and closure
• Moisture balance of the wound bed is critical for wound healing
What is one of the major roles of the PT in wound healing?
Wound Bed Preparation
When does the PT perform wound bed preparation?
After comprehensive examination : Assessment
What are the events that occur in the assessment of a wound?
• Determine the ability of the wound to heal (includes underlying cause, pt
status, complicating factors, etc. “broad picture”)
- Healable (address underlying cause)
- Maintenance (potential but barriers)
- Non-healable/palliative (irreversible causes/illnesses)
• Once status determined, appropriately dose care
What should be done if a wound falls into the “healable” assessment of a wound?
• Address underlying cause • Move to “local wound care” or DIME - Debridement - Inflammation/infection - Moisture balance - Edge effect
What is DIME used for?
Use to determine approach to local wound care & wound assessment
– If you have no idea where to start, start here!
What are the components of “debridement” in DIME?
What tissues are present, safe to debride, type, frequency
What are the components of “inflammation/infection” in DIME?
What stage of healing, immunocompromised, activity, s/s of infection, s/s out
of proportion for phase of healing
What are the components of “moisture balance” in DIME?
Tissue type/quality, maceration, activity, infection, dressing schedule, out of proportion, add or absorb moisture
What are the components of “edge effect” in DIME?
Progressing, stalled/rolled, callus, clean
Where is patient history gathered from?
From patient, medical record, family, caregivers etc.
What are the components included in the patient history?
- General Demographics
- Lifestyle and Functional Status
- Past and Current Medical History
- Past and Current Wound History
- Systems Review
What is included in the general demographics portion of the patient history?
- Age
- Sex
- Ethnicity
- Primary language
- Education
What is included in the lifestyle and functional status portion of the patient history?
- Living environment
- Prior and current level of function
- Employment
- Health habits (smoking, ETOH, nutrition, sleep, stress)
What is included in the past and current medical history portion of the patient history?
- All the usual information collected (Review of systems)
- Medications
- Allergies
What is included in the past and current wound history portion of the patient history?
- Acute or Chronic (How long has the wound been present? When and how did you get the wound?)
- Has the patient had any tests run (labs, wound cultures, vascular studies, radiologic studies)?
- Has the wound improved or is it getting worse?
- Pain
- Other wounds in the past
- Dressing being used and when last changed
What are the wound specific tests and measures?
- Location
- Size
- Wound bed (Tissues)
- Wound edges
- Drainage
- Odor
- Periwound
How do we use the location of a wound as a test and measure for the wound?
• Correct terminology to describe location
- Be specific & consistent
- Medial/lateral, left/right, proximal/distal, etc.
• Body chart or drawings
• Photos
• Multiple wounds
- Assign numbers
How do we use the size of a wound as a test and measure for the wound?
Direct measurement (in cm)
• Length (longest)
• Width (perpendicular to length)
• Depth (deepest)
Clock Method: 12-o’clock in area of wound closest to head, but
can be assigned a different position by clinician
• Length (12-6)
• Width (9-3)
• Depth (various clock positions, 2,4,8,10, or others)
How do we use the wound bed as a test and measure for the wound?
Tissue Identification- Describe in percentages present
What are the types of tissue that can be present in a wound bed?
• Granulation tissue
• Necrotic or non-viable
• Fascia, adipose, muscle, tendon, joint capsule, bone, new
epithelium
What is the granulation tissue that can be present in a wound bed?
Temporary scaffolding of vascularized connective tissue; healthy granulation is bright beefy red; if pale or dusky, blood supply may be poor or may be infected.
This is the type of tissue we want
What is the necrotic or non-viable tissue that can be present in a wound bed?
- Slough- yellow or tan, stringy or mucinous
* Eschar- black necrotic tissue, soft or hard, wet or dry, adherent or nonadherent to the wound bed
What is undermining?
When the - tissue under wound edge is gone, similar to a cave under the skin, “waggle room”
• Documentation example: undermining of 4 cm from 10-12 o’clock
What is a tract?
Narrow passageway, tube like extension of wound
• Documentation example: Tract at 5 o’clock 7 cm.
What is a tunnel?
Entrance and exit
• Document location and length
What are the ways that a wound edge can be?
- Well defined (demarcated) or defuse
- Thick or thin
- Attached to wound base(preferred) or raised or rolled (epibole: new epithelium is rolling over itself, requires surgery to correct)
- Color
- Evidence of epithelialization
How is the drainage of a wound described?
Type, Color, Consistency, Amount
What are the characteristics of serous drainage seen on a wound?
- Protein rich fluid with white blood cells
* Clear-pale yellow, watery
What are the characteristics of sanguineous drainage seen on a wound?
- Blood or drying blood
* Red-dark brown, consistency of blood or slightly thickened water
What are the characteristics of purulent drainage seen on a wound?
- Indicator of infection
* White-pale yellow, viscous or creamy consistency
What are the characteristics of the amount drainage seen on a wound?
None, minimal, moderate, copious
• Must consider dressing used and when last changed
When is the odor of a wound assessed?
Assessed after irrigation
• Present or absent
What causes the odor of a wound?
- Wound infection
- Non-viable tissue
- Old dressing
- Hot weather
What are the components that needs to be assessed in a periwound?
• Palpation - induration, fluctuance, general edema, increased
temp, etc.
• Maceration (macerated), healthy, intact, dry/peeling, etc.
• Skin: color, texture, dryness, hair, etc.
• Callus
• Local signs & symptoms of infection
• Sensation
• Circulation
What are healthcare-associated Infections (HAI)?
Infections patient get while receiving treatment for medical or surgical conditions
What are the most common healthcare-associated Infections (HAI)?
- Central line-associated bloodstream infections
- Catheter-associated urinary tract infections
- Surgical site infections
- Ventilator-associated pneumonia
_____ is key towards healthcare-associated Infections (HAI)
Prevention is key towards healthcare-associated Infections (HAI)
What are the ways to prevent healthcare-associated Infections (HAI)?
- Wash hands
* Prevent contamination from one patient to the next
The opportunities for handwashing are before and after what…?
- Wearing Gloves
- Patient Contact
- Any Patient Procedure
- Environmental or equipment contact