week 1 Flashcards

1
Q

Why is it called primary GINGIVOSTOMATITIS?

A

Due to the site of lesions on the gingiva

AND/OR on ANY: oral mucosa

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2
Q

secondary HSV

  • age
  • systemic
  • oral 1 (3 locations)
A

Age: Usually puberty and after…
Systemic: none
Oral: Vesicles->ulcers
located: 1. Gingiva 2. Hard palate 3. Lips

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3
Q

Differential diagnosis HSV primary (3)

A

Streptococcal Pharyngitis

Erythema multiforme

ANUG

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4
Q

Differential HSV primary (3) reasons it is not each

  • SP (1)
  • EM (4)
  • AN (3)
A

Strep- Pharyngeal (posterior lesions) palate/post mouth
Erythema Multi- requires a sensitivity (usually very immediate timing. Target lesion. LARGE crusty lesions on LIP/Buccal mucosa NOT ON GINGIVA!!!!

ANUG-STENCH, [Bleeding gums w/o brushing], commonly has stress or immunocompromised host]

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5
Q

Treatment for Diff diagnosis HSV
(3)
SP EM ANUG

A

Strep- Streptococcal antibiotics
Erythema Multi- Steroids for type 3/2 hypersens.
ANUG- Oral hygeine and ANUG specific Antibiotics

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6
Q

Differential Diagnosis for HSV secondary

  • disease
  • Reason it is not (3)
A

Aphthous ulcers

  • No tingling prodromal phase
  • Non-keratinized tissue ONLY!!!!
  • Never has a vesicle or bulla prior to the ulcers
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7
Q

What is a cause for secondary HSV lesions to not be restricted to Ging, Hard palate, or lips? (2)

A

Immunocompromised - AIDS etc

Chemotherapy

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8
Q

What are 4 ways to determine HSV diagnosis if the clinical signs are insufficient?

A
  • Biopsy (painful and invasive)
  • Fluorescent antibody test (via smear) can be inconclusive with other similar viral DNA (Herpetic family etc)
  • Insitu hybridization (expensive)
  • Culture (1-3 days)
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9
Q

Pro / con of Biopsy vs smear cytology

A

Biopsy is invasive/painful

Smear will not show tissue architecture (may be inconclusive or lack specificity)

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10
Q

Tzanck (z-(t)ank) Tank but starts with a z sound…

-indicates it could be what possible diseases? (4)

A
HSV 
VZV
Cytomegalovirus
or
Pemphigus vulgaris (common pemphigus)
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11
Q

Describe a Tzanck cell (2)

-what cells are they initially?*

A

Balloon and glassy

-initially prickle cells of epithelium (obviously of Keratinized tissue)

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12
Q

What is the primary systemic concern for prescribing valtrex for a viral infection?

A

Kidney function

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13
Q

Supportive care for Primary HSV infection: non-immunocompromised (4) and if fever 1 more (children vs adults)

A
  1. Rest
  2. Fluids
  3. Soft food
  4. Xylocaine 2%
    * Fever
    5c. Tylenol (often children so no aspirin)
    6a. Aspirin (adults)
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14
Q

What timing window must be met before giving medication for any HSV?

A

48 hrs of onset of prodromal symptoms (tingling)

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15
Q

Can we treat a patient for a TOOTH problem if they have an active secondary HSV infection?
-Why might you not treat?

A

CAREFULLY and only if they have an emergent issue.

  • otherwise reschedule them
  • -We do not want to spread the involved tissues to another area of the patients face or mouth
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16
Q

Can you premed a patient that has NO signs of a secondary HSV infection (not even tingling)?
-What are they? (3)

A

Yes

  1. Lysine (consistent preventative)
  2. Valcyclovir (expensive but bid)
  3. Acyclovir (cheap but 5x a day)
17
Q

Mode of infection VZV

A

Droplets

18
Q

People infected with chicken pox

A

usually children

Adults are either old or immunocompromised

19
Q

Zoster (shingles)

  • who
  • Where (2)
  • PAIN?
  • Lesions? (2)
A

Age- old / immunocompromised
Where- Follows dermatomes AND UNILATERAL!!!
Pain is severe
Lesions- MACULES and papules (maculo-papular lesions)

20
Q

Ramsay hunt syndrome is related to ______ specifically in the ______ ganglion?

A

VZV (zoster) in the Geniculate ganglion (facial nerve)

***VZV still means it is unilateral!!!!

21
Q

4 general complications of zoster?

A

Infection of maculo-papule lesions -> ulcers
Neuralgia
Motor paralysis
Ocular inflammation

22
Q

differential for VZV (2)

why is it not each

A

HSV-shorter term less pain

Hand foot and mouth disease-lesions on hands and feet…

23
Q

HSV scenario

  • age
  • systemic symptoms 5
  • Oral symptoms 4
A

Age: young
Systemic: Fever, malaise, lymphadenopathy, ARTHRALGIA, ANOREXIA
Oral: TINGLING, red, swollen, bleeding gums

24
Q

Traits of VZV

  • Virus type
  • Age(s) involved
  • Route of infection
  • Lesions (describe location, secondary problems, symptom(s))
A

DNA virus
young, or OLD/immunocompromised
Droplet infection (pneumonia like symptoms for varicella)
Lesions: trunk,head/neck
-often get bacterial infections in lesions
-intense pruritus

25
Q

Days knocked off of HSV infection by use of prompt (w/in 48 hrs)

A

At best 2 days… more like 1.5

26
Q

Theapies for Zoster infections

  • Supportive
  • Immunocompromised(3)
A

Supportive Acyclovir: 800mg 5xa-day 7-10 days

Immuno: Systemic antiviral
vidarabine
human leukocyte interferon

27
Q

Hand foot and mouth disease description

  • Virus nucleic acids and type and family
  • GROUP infection class
  • Route of infection
  • Age
A
  • RNA of piconavirus/Coxsackie Group
  • Endemic/epidemic
  • Airborne OR fecal-oral
  • Usually under age 5
28
Q

Hand foot and mouth description cont

  • Incubation time
  • Symptoms (4)
A

Incubation time: Short (fast onset)
Sypmtoms:
123 Low fever, Malaise, Lymphadenopathy
4 SORE MOUTH

29
Q

Hand foot and mouth cont again…description

  • Disease progression?
  • Treatments (2)
A

The disease usually does not progress (self-limiting AND spontaneous resolution)

Treatment: 1 WARM sodium bicarb mouth wash AND 2 tylenol

30
Q

Herpangina description

  • age
  • Time of year
  • Route of infection
A

kids
summer
fecal oral

31
Q
herpangina cont
symptoms 
-Location (3) OF VESICLES
-vesicles manifest as \_\_\_\_\_\_
-Non-lesion sypmtoms (4)
-Self limiting?
A

Vesicle location: Soft palate, faucial pillars and tonsils
They manifest in crops (like VZV)
Fever and malaise AND sore throat/dysphagia
IS self limiting

32
Q

Measles A.K.A.

  • Virus type and Nucleic acids
  • Spread via
  • Age/time of year
  • Prodromal symptoms (3)
A
  • paramyxovirus RNA A.K.A: Rubeola
  • Airborne droplets
  • Kids in WINTER
  • Prodromal: fever and lesion tingling! (like HSV)
  • –Oral lesions!
33
Q

Measles: Rubeola
classic oral symptom:
-specific location
-describe oral alteration (3)

A

Koplik’s Spots

  • Found on BUCCAL mucosa
  • Red MACULE
  • Necrotic center
34
Q

Measles: Rubeola

-Histo path– cell name, location and description

A

Histopathology: Warthin-Finkeldey Giant cells

  • found in: Lymph tissues
  • Desc: Multinucleated Macrophages
35
Q

-4 dangerous complications of measles

A
Encephalitis
Throbocytopenic purpura
-Secondary infections:
---Otitis media 
---Pneumonia
36
Q

Treatment of Measles/Rubeola

A

Treat the symptoms

  • Fever (NSAIDS)
  • Fluids
  • (etc….)
37
Q

German measles A.k.A and Family

  • Spread via?
  • Similar to _______ but more MILD or SEVERE?
A

Aka Rubella of the TOGA family
Spread via: “contagious” i would assume aerosols
Similar to Measles (rubeola) but more MILD