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Skin, Muscle, Bone > Week 1 > Flashcards

Week 1 Flashcards

1
Q

MOA of acyclovir

A

inhibits DNA synth to halt viral reproduction

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2
Q

MOA of valacyclovir

A

inhibits DNA synth to halt viral reproduction

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3
Q

MOA of famciclovir

A

Pro-drug of penciclovir, inhibits HSV DNA polymerase

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4
Q

MOA of docosanol

A

interferes w/ adoption of viral envelope into cells

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5
Q

indications for acyclovir

A

HSV, VZV, EBV, CMV

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6
Q

indications for valavyvlovir

A

HSV, VZV, EBV, CMV

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7
Q

indications for famciclovir

A

HSV, VZV

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8
Q

indications for docosanol

A

topical for HSV on lips or face

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9
Q

contraindications for acyclovir

A

use w/ caution in immunocompromised patients

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10
Q

contraindications for valacyclovir

A

use w/ caution in immunocompromised patients

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11
Q

contraindications for famciclovir

A

none really

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12
Q

contraindications for docosanol

A

not really

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13
Q

AEs for acyclovir

A

local irritation, NVD

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14
Q

AEs for valavyvlobir

A

local irritation, NVD

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15
Q

AEs for famciclovir

A

HA, nausea (tablets contain lactose)

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16
Q

AEs for docosanol

A

none

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17
Q

drug interactions for the topical and oral meds used to treat skin infections

A

none

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18
Q

what medications cover MSSA and strep

A

cephalexin, dicloxicillin

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19
Q

what is the empiric coverage for CA MRSA in outpatients

A

clinda, TMP-SMX, DCN or MCN, linezolid

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20
Q

what is the treatment for suspected CA MRSA and beta-hemolytic strep?

A

clinda, TMP-SMX, DCN or MCN, linezolid

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21
Q

MOA of neomycin

A

inhibits bacterial protein synthesis

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22
Q

MOA of bacitracin

A

inhibits bacterial cell wall synthesis

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23
Q

MOA of mupirocin

A

inhibits bacterial protein synthesis

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24
Q

MOA of clindamycin

A

inhibits protein synthesis

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25
Q

MOA of TMP-SMX

A

inhibits folic acid syntehsis

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26
Q

MOA of cephalexin

A

inhibits cell wall synthesis

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27
Q

MOA of dicloxacillin

A

inhibits cell wall synthesis

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28
Q

indications for neomycin, bacitracin

A

topical infections (scrapes, burns etc)

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29
Q

contraindications for neomycin, bacitracin

A

hypersensitivity, mycobacterium of fungal infection

30
Q

AEs of neomycin, bacitracin

A

redness, contact derm., itching, anaphylaxis (staph resistance occurs in 48 hours!)

31
Q

indications for mupirocin

A

impetigo, secondary skin infections, elimination of MRSA from nose of carriers

32
Q

contraindications for mupirocin

A

hypersensitivity, not to be used in pregnancy

33
Q

AEs of mupirocin

A

HA, local burning, pruritis

34
Q

drug interactions of mupirocin

A

antibiotics diminish the effect of vaccines

35
Q

indications for clindamycin

A

purulent and non-purulent SSTI, bacterial vaginosis suppository

36
Q

contraindications for clindamycin

A

hypersensitivity, previous C. diff

37
Q

AEs of clindamycin

A

topical: xeroderma, burning, pruritus
oral: N/V/D, jaundice, easy bruising

38
Q

drug interactions of clindamycin

A

antibiotics diminish the effect of vaccines

39
Q

indications for TMP-SMX

A

broad spectrum, UTI, AOM, traveler’s diarrhea, bite wounds, SSTI

40
Q

contraindications for TMP-SMX

A

allergy to sulfa

41
Q

AEs of TMP-SMX

A

SJS, hemolytic anemia, N/V/D, kernicterus, kidney stones

42
Q

drug interactions w/ TMP-SMX

A

increase INR, decrease metabolism of phenytoin, decreased metabolism of methotrexate

43
Q

indications of cephalexin

A

PEcK, impetigo

44
Q

contraindications of cephalexin

A

hypersensitivity, possible cross reactivity w/ PCN

45
Q

AEs of cephalexin

A

HA, dizziness, rash, may elevate INR

46
Q

drug interactions of cephalexin

A

decreases metabolism of metformin

47
Q

indications for dicloxicillin

A

staph, osteomyelitis, animal bites, impetigo

48
Q

contraindications of dicloxicillin

A

PCN hypersensitivity, do not use in kiddos

49
Q

AEs of dicloxicillin

A

hypersensitivity, C. diff, hemolytic anemia, N/V/D

50
Q

drug interactions of dicloxicilli

A

inducer leads to decreased hydrocodone? PCN causes increase in serum methotrexate

51
Q

pt. education for dicloxicillin

A

can make birth control less effective

52
Q

allyamines (drug names)

A

terbinafine, griseofulvin

53
Q

MOA of terbinafine

A

inhibits ergosterol production, therefore inhibiting fungal cell wall synthesis?

54
Q

MOA of griseofulvin

A

fungistatic that arrests cells in metaphase

55
Q

indications for terbinafine

A

topical: all tineas
oral: onychomycosis, tinea capitis

56
Q

indications for griseofulvin

A

tineas, infections by microsporun, epidermophyton, trichophytan

57
Q

contraindications for terbinafine

A

hypersensitivities

58
Q

contraindications for griseofulvin

A

hypersensitivities, do not use if pregnant

59
Q

AE of terbinafine

A

HA, fever, rash, diarrhea, nasopharyngitis, cough, rare; SJS, exacerbation of lupus

60
Q

DI of terbinafine

A

CYP inhibitor

61
Q

AE of griseofulvin

A

HA, rash, urticaria, rare: SJS, jaundice

62
Q

DI of griseofulvin

A

hormonal BC is less absorbed

63
Q

triazoles (drug names)

A

fluconazole, itraconazole

64
Q

indications of fluconazole

A

candidia, cryptococcal meningitis

65
Q

indications of itraconazole

A

fungal infections in immunocompromised and immunocompetent pts. including blasto and histo. aspergillosis in pts. w/ amph B intolerance. Onychomycosis

66
Q

contraindications of fluconazole

A

hypersensitivities

67
Q

contraindications of itraconazole

A

hypersensitivities, pts. w/ hx of heart failure or at risk of heart disease, do not use while breastfeeding or if pregnant or intending to become pregnant

68
Q

AE of fluconazole

A

N/V/D, HA, rash, some reports of SJS

69
Q

AE of itraconazole

A

BLACK BOX warning: serious CV side effects including tachycardia and cardiac arrest, N/V/D, HA, rash, abd. pain, edema, hypertension, rare: SJS

70
Q

DI of fluconazole

A

coadministration of CYP substrates may lead to QT prolongation and other drug interactions

71
Q

DI of itraconazole

A

lots, drug inhibits CYP

72
Q

imidazoles (drug names)

A

clotrimazole, miconazole, ketoconazole

Skin, Muscle, Bone (2 decks)

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