Week 1 Flashcards
What are the 3 chemical classification of hormones
Amines, peptides, steroids
How are each chemical classification of the hormones made
Amines: derived from the amino acid tyrosine or tryptophan
Peptides: synthesized by translation of mRNA on ribosomes
Steroids: synthesized from cholesterol
What are 3 examples of amine hormones
Adrenaline
Thyroxine
Melatonin
What are r examples of peptide hormones
Insulin
Glucagon
GH
FSH
ADH
What are 3 examples of steroids hormones
Sex hormones
Cortisol
Aldosterone
Which hormones are hydrophilic
All amines except thyroid hormones and proteins/peptides
Which hormones are hydrophobic
Steroids hormones and thyroid hormones
What is autocrine
Chemical messengers that are released by the secretory cells to act on the same cell
What is paracrine
Chemical messengers that are released by the secretory cells to act on neighboring cells
Eg: histamine
Endocrine
Hormones that are released by the secretory cells to act into the blood stream
What is the mechanism for the action of hydrophilic hormones
- Hormones act on surface membrane receptors
- This activates an enzyme inside the membrane
- This enzyme activated other enzymes that are collectively called kinases
- The cascade generates an amplified response
What is the mechanism for the action of hydrophobic hormones
- Hydrophobic hormones diffuse through the cell membrane
- They then bind to intracellular receptors either in the cytoplasm or nucleus
- They then bind to hormone responsive elements to control gene expression
What triggers the release of a hormone
Describe each stimuli
Humoral stimuli: in response to a change in the internal environment of the body eg: blood glucose levels, sodium/potassium levels
Neuronal stimuli: a response to emotional or physical stress, or cognitive associations
Hormonal stimuli: in response to another hormone
Describe the negative feedback loop when GHRH (growth hormone releasing hormone)
When GHRH that is produced from the hypothalamus increase this:
1. Stimulates the pituitary gland to release GH
2. GH acts on liver and all cells
3. Liver produces IGF-1
4. IGF-1 decreases the amount of GH and GHRH
How does glucose stimulate insulin secretion
- Glucose enters the cell via the GLUT2 transporter
- Glucose inside the cell is phosphorylated to G6P via the enzyme glucokinase
G6P is metabolized to ATP through the TCA cycle, glycolysis, and OX/PHOS by beta cells - This increases the ATP:ADP intracellular ratio
- This closes an ATP-sensitive K+ channel
- Cell membrane is depolarized
- Voltage gates Ca2+ channel open
- Intracellular Ca2+ activate microtubule-mediated exocytosis if insulin