Week 1

Question 1

What is a symptom of mast cell degranulation?

Answer 1

Itching

Question 2

What dermatological condition is characterised by intermittent pruritus and desquamating skin?

Answer 2

Contact hypersensitivity

Question 3

Management of Anaphylaxis

Answer 3

ABCDE

IM adrenaline 1ml 1:1000

Question 4

Management of acute urticaria

Answer 4

PO antihistamines

Question 5

Management of allergic rhinitis

Answer 5

PO antihistamines

Question 6

Management of angioedema

Answer 6

ABCDE

IM adrenaline 0.5ml 1:1000

Question 7

Cytokines exerting an anti-viral effect

Answer 7

Interferons

Question 8

Immunoglobulin diner

Answer 8

IgA

Question 9

MHC associated with Th1 cells and Th2 cells

Answer 9

MHC class 2

Question 10

Acts on hepatocytes to induce synthesis of active phase proteins in response to bacterial infection

Answer 10

Il6

Question 11

Arise in the first few days and are important in defence against viruses and tumours

Answer 11

NK cells

Question 12

MHC associate with cytotoxic T cells

Answer 12

MHC class 1

Question 13

Deficiencies in this predispose to SLE

Answer 13

Classical complement pathway

Question 14

Kostmanns syndrome is a congenital deficiency of which component of the immune system

Answer 14

Neutrophils

Question 15

Meningococcal infections are quite common as a result of a deficiency of the component as a result of which deficiency of the component of the immune system?

Answer 15

Complement

Question 16

A complete deficiency in this molecule is associated with recurrent respiratory and gastrointestinal infections

Answer 16

IgA

Question 17

What is the functional complement test used to investigate the classical pathway

Answer 17

CH50

NB: starts with “C”

Question 18

Name two type IV T-cell mediated conditions

Answer 18

Rheumatoid arthritis

Type 1 diabetes

Question 19

Name a type III-immune complex mediated condition

Answer 19

Hep C associated membranoproliferative glomerulonephritis type I

Question 20

What is the specific auto-antigen that is the target of the immune system in Goodpasture’s syndrome

Answer 20

Type IV collagen

Question 21

What is the most diagnostic antibody for SLE?

Answer 21

Anti-DNA antibody

Question 22

What is the most diagnostic antibody for Wegner’s granulomatosis

Answer 22

c-ANCA

Question 23

What is the most diagnostic antibody for Rheumatoid arthritis?

Answer 23

Anti-CCP antibody

Question 24

What is the most diagnostic antibody for AIHA

Answer 24

Coomb’s test

Question 25

What is the most diagnostic antibody for Primary biliary cirrhosis?

Answer 25

Anti-microbial antibody

Question 26

What two organs does Goodpasture’s syndrome typically affect?

Answer 26

Kidney and lung

Question 27

A liver enzyme raised after an MI

Answer 27

AST

Question 28

Levels of which liver product affected by diet?

Answer 28

Albumin

Question 29

What is the measure of the intrinsic pathway?

Answer 29

APPT

Question 30

What is the measure of the extrinsic pathway?

Answer 30

Prothrombin time

Question 31

What is the antibody for coeliac disease?

Answer 31

Anti-endomysial antibodies | Tissue-transglutaminase antibodies

Question 32

What is the antibody for pernicious anaemia?

Answer 32

Anti-intrinsic factor antibodies | Gastric parietal antibodies

Question 33

What is the antibody for wegner’s granulomatosis

Answer 33

C-ANCA NB: antibody to proteinase-3: 3 is the third letter of the alphabet

Question 34

What is the test for spherocytosis?

Answer 34

Osmotic fragility test

Question 35

What is the antibody for primary biliary cirrhosis?

Answer 35

Anti-microbial antibody

Question 36

What is the test for Paroxysmal nocturnal haemoglobinuria

Answer 36

Ham’s test

Question 37

What is the antibody for T1DM

Answer 37

Anti-glutamic acid decarboxylase antibodies (Anti-GAD)

Question 38

What are the features of digoxin toxicity?

Answer 38

- arrhythmia - anorexia, N+V - confusion - yellow vision (xanthopsia), blurred vision and photophobia

Question 39

Which Abx is too toxic and nephrotoxic?

Answer 39

Gentamicin

Question 40

Which drug overdose is this: bright red skin and faint odour of almonds?

Answer 40

Cyanide

Question 41

What is the treatment for Beta-blocker overdose?

Answer 41

Glucagon

Question 42

What is the treatment for Organophosphate overdose?

Answer 42

Activated charcoal

Question 43

What is the treatment for Salicylate overdose?

Answer 43

1. Activated charcoal (within 1 hr) OR Haemodialysis if metabolic acidosis

Question 44

What is the treatment for CO poisoning?

Answer 44

Oxygen

Question 45

What is the management of amphetamine overdose?

Answer 45

Symptomatic and supportive treatment

Question 46

Which technique can be used to test for all drugs of abuse (DOA)?

Answer 46

Immunoassay

Question 47

Which sample is required for use with gas chromatography mass spectrometry?

Answer 47

Blood sample

Question 48

Colorimetric can be used to test for which drug commonly taken in overdose?

Answer 48

Paracetamol

Question 49

Which of the above techniques can be used to test for benzodiazepines and various antipsychotic drugs?

Answer 49

Liquid chromatography

Question 50

Which technique can be used to analyse samples of stool, liver and also urine?

Answer 50

Thin layer chromatography

Question 51

Which drug is not excreted into saliva?

Answer 51

THC