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Week 1 Flashcards

1
Q

What is a symptom of mast cell degranulation?

A

Itching

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2
Q

What dermatological condition is characterised by intermittent pruritus and desquamating skin?

A

Contact hypersensitivity

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3
Q

Management of Anaphylaxis

A

ABCDE

IM adrenaline 1ml 1:1000

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4
Q

Management of acute urticaria

A

PO antihistamines

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5
Q

Management of allergic rhinitis

A

PO antihistamines

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6
Q

Management of angioedema

A

ABCDE

IM adrenaline 0.5ml 1:1000

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7
Q

Cytokines exerting an anti-viral effect

A

Interferons

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8
Q

Immunoglobulin diner

A

IgA

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9
Q

MHC associated with Th1 cells and Th2 cells

A

MHC class 2

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10
Q

Acts on hepatocytes to induce synthesis of active phase proteins in response to bacterial infection

A

Il6

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11
Q

Arise in the first few days and are important in defence against viruses and tumours

A

NK cells

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12
Q

MHC associate with cytotoxic T cells

A

MHC class 1

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13
Q

Deficiencies in this predispose to SLE

A

Classical complement pathway

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14
Q

Kostmanns syndrome is a congenital deficiency of which component of the immune system

A

Neutrophils

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15
Q

Meningococcal infections are quite common as a result of a deficiency of the component as a result of which deficiency of the component of the immune system?

A

Complement

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16
Q

A complete deficiency in this molecule is associated with recurrent respiratory and gastrointestinal infections

A

IgA

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17
Q

What is the functional complement test used to investigate the classical pathway

A

CH50

NB: starts with “C”

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18
Q

Name two type IV T-cell mediated conditions

A

Rheumatoid arthritis

Type 1 diabetes

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19
Q

Name a type III-immune complex mediated condition

A

Hep C associated membranoproliferative glomerulonephritis type I

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20
Q

What is the specific auto-antigen that is the target of the immune system in Goodpasture’s syndrome

A

Type IV collagen

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21
Q

What is the most diagnostic antibody for SLE?

A

Anti-DNA antibody

22
Q

What is the most diagnostic antibody for Wegner’s granulomatosis

A

c-ANCA

23
Q

What is the most diagnostic antibody for Rheumatoid arthritis?

A

Anti-CCP antibody

24
Q

What is the most diagnostic antibody for AIHA

A

Coomb’s test

25
Q

What is the most diagnostic antibody for Primary biliary cirrhosis?

A

Anti-microbial antibody

26
Q

What two organs does Goodpasture’s syndrome typically affect?

A

Kidney and lung

27
Q

A liver enzyme raised after an MI

A

AST

28
Q

Levels of which liver product affected by diet?

A

Albumin

29
Q

What is the measure of the intrinsic pathway?

A

APPT

30
Q

What is the measure of the extrinsic pathway?

A

Prothrombin time

31
Q

What is the antibody for coeliac disease?

A

Anti-endomysial antibodies

Tissue-transglutaminase antibodies

32
Q

What is the antibody for pernicious anaemia?

A

Anti-intrinsic factor antibodies

Gastric parietal antibodies

33
Q

What is the antibody for wegner’s granulomatosis

A

C-ANCA

NB: antibody to proteinase-3: 3 is the third letter of the alphabet

34
Q

What is the test for spherocytosis?

A

Osmotic fragility test

35
Q

What is the antibody for primary biliary cirrhosis?

A

Anti-microbial antibody

36
Q

What is the test for Paroxysmal nocturnal haemoglobinuria

A

Ham’s test

37
Q

What is the antibody for T1DM

A

Anti-glutamic acid decarboxylase antibodies (Anti-GAD)

38
Q

What are the features of digoxin toxicity?

A
  • arrhythmia
  • anorexia, N+V
  • confusion
  • yellow vision (xanthopsia), blurred vision and photophobia
39
Q

Which Abx is too toxic and nephrotoxic?

A

Gentamicin

40
Q

Which drug overdose is this: bright red skin and faint odour of almonds?

A

Cyanide

41
Q

What is the treatment for Beta-blocker overdose?

A

Glucagon

42
Q

What is the treatment for Organophosphate overdose?

A

Activated charcoal

43
Q

What is the treatment for Salicylate overdose?

A
  1. Activated charcoal (within 1 hr)
    OR
    Haemodialysis if metabolic acidosis
44
Q

What is the treatment for CO poisoning?

A

Oxygen

45
Q

What is the management of amphetamine overdose?

A

Symptomatic and supportive treatment

46
Q

Which technique can be used to test for all drugs of abuse (DOA)?

A

Immunoassay

47
Q

Which sample is required for use with gas chromatography mass spectrometry?

A

Blood sample

48
Q

Colorimetric can be used to test for which drug commonly taken in overdose?

A

Paracetamol

49
Q

Which of the above techniques can be used to test for benzodiazepines and various antipsychotic drugs?

A

Liquid chromatography

50
Q

Which technique can be used to analyse samples of stool, liver and also urine?

A

Thin layer chromatography

51
Q

Which drug is not excreted into saliva?

A

THC

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