Week 06 Fluid Flow Lecture Flashcards

1
Q

What is volumetric flow rate?

Its equation?

A
  • the amount of volume passing a point per unit time
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2
Q

What is viscocity?

What does it measure?

What does it depend on highly?

A
  • the “internal friction” of a fluid that arises from collisions between neighboring particles moving at different velocities
  • measures resistance to deformation due to shear or tensile stress
  • highly dependent on temperature … higher temp = lower viscocity
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3
Q

How can viscocity be calculated?

What are the units of viscocity?

A

Viscocity = Shear Stress / Velocity Gradient

(see equation below)

  • Pascals (Pas) … N⋅s/m2

…or poise (p)

  • 1 Pas = 10 p
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4
Q

What is a velocity gradient in relation to modeling viscocity?

A

A fluid can be modeled as layers on top of each other.

The bottom layer moves least due to pressure from the above layers.

The top layer moves most, due to lack of pressure.

All layers in between have a velocity gradient based on the increasing pressure from above as you move down through the layers.

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5
Q

What are the 3 main basic types of fluids and their properties?

A
  1. Ideal - frictionless, non-compressible (constant ⍴), non-viscous
  2. Real Newtonian - constant viscocity (ind. of shear stress)
  3. Real Non-Newtonian - visc. changes w/ shear stress (AKA anomalous)
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6
Q

How do the (4) different types of real fluids react to variations in shear stress?

This includes the various types of anomalous fluids.

A
  • Newtonian - linear relationship btwn shear stress and velocity gradient starting from origin
  • St. Venant - does not flow at all, until a shear stress threshold at which it begins to flow almost perfectly
  • Bingham - has a linear relationship once threshold is met
  • Casson - has exponential relationship once threshold is met
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7
Q

What are the 3 different types of fluid flow?

A
  1. Stationary - constant volumetric flow rate
  2. Laminar - fluid layers do not mix
  3. Turbulent - fluid layers mix
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8
Q

What is the continuity equation?

Describe the theory behind it.

A

A1v1 = A2v2

A = cross-sectional area

v = flow velocity

  • a volume of fluid has a higher flow velocity (NOT vol. flow rate) in a tube with a smaller cross-sectional area
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9
Q

What is the engineering model of a viscoelastic body called?

What are its two parts and what do they represent?

A

Kelvin Body

  • spring (rubbery, but solid, non-flowing quality) and dashpot (viscocity) coupled in parallel
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10
Q

What does the Reynolds number of a fluid flow system indicate?

What factors increase Reynolds number?

What is the equation?

A
  • whether a fluid will flow laminarly or turbulently
    • _​_Rc = 2000 is cutoff between flow types
    • higher number = more turbulence
  • factors increasing R:
    • increased radius
    • increased flow velocity
    • increased fluid density
    • decreased fluid viscocity
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11
Q

What is Bernoulli’s Law?

What is its equation?

A
  • the sum of all forms of energy (pressure) in a fluid along a streamline is the same at all points on that streamline (law of conservation of energy)
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12
Q

What are the 3 types of pressures relevant to Bernoulli’s law?

A
  1. Static - pressure exerted by fluid on wall of vessel
  2. Dynamic - pressure difference between inlet/outlet of tube, maintains Ekin of flow
  3. Hydrostatic - pressure measured at the bottom of fluid column
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13
Q

What effect does Bernouli’s law create in fluid flow systems?

A

Venturi effect

  • the reduction in fluid pressure that results when a fluid flows through a constricted section of pipe
  • results because the fluid velocity must increase in accordance with the continuity equation, so the pressure must decrease to keep the sum of all energies within the system constant
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14
Q

What is Stokes Law?

What two kinds of fluid/object situations does it pertain to?

A
  • an equation which relates Stokes Force/Drag to flow rate, radius of object in the flow and viscocity
  • affects stationary objects in moving fluid and moving objects in stationary fluid (ie spermatocytes)
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15
Q

What assumptions does Stokes Law make for the behaviour of a particle in fluid?

A
  • Laminar Flow
  • Spherical particles
  • Homogeneous (uniform in composition) material
  • Smooth surfaces
  • Particles do not interfere with each other
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16
Q

What is the Hagen-Poiseuille Law?

A

a physical law that gives the pressure drop in an incompressible and Newtonian fluid in laminar flow flowing through a long cylindrical pipe of constant cross section

17
Q

What is the medical significance of Bernoulli’s law?

A

Aneurysm

  • vessel expands, ^ diameter
  • expansion causes decreased flow rate (continuity eqn.)
  • decreased flow rate causes static pressure increase (Bernoulli’s Law)
  • aneurysm eventually bursts due to + feedback mechanism of ever-increasing vessel diameter > pressure
18
Q

What is the medical signifance of the Hagen-Poiseuille Law?

A

Oxygen delivery changes DRASTICALLY with small changes in vessel diameter (because of fourth-power dependence of flow intensity on vessel radius)

  • changes in blood viscocity in fever/anemia also have an effect
19
Q

What is the average volume of blood in an adult?

Viscocity?

Density?

Composition?

A
  • volume: 5 liters
  • viscocity: 5 mPas
  • density: 1.05 g/cm3
  • composition: 40-45% corpuscular, 55-60% plasma
20
Q

What are the 6 main determinants of blood viscocity?

A
  1. **Hematocrit **- % total blood volume made up of cells
  2. Plasma Viscocity - plasma protein concentration
  3. RBC plasticity - suspension of similar-sized, non-plastic particles would not flow
  4. RBC aggregation - at low flow rate, RBCs form roleaux (stacks) and visc. increases
  5. **Flow rate **- slow flow = roleaux, very fast flow = “sheets”
  6. **Vessel Diameter **- low vessel diameter (capillaries) causes single-file RBC flow
21
Q

What condition would increase plasma viscocity?

A

paraproteinaemia

  • increase in immunoglobulins
22
Q

What is the Fahraeus-Lindquist effect?

A

the apparent decrease in viscocity that occurs when RBCs flow in single-file in capillaries, causing a decrease in velocity gradient in the center of the vessel but an increase in the gradient at the walls of the vessel

23
Q

What are the functions of the vascular system?

A

maintaining environmental paramaters of cells by transporting:

  • Gases
  • Metabolites
  • Hormones, signal transmitters
  • Immunoglobulins
  • Heat
24
Q

What 3 hemodynamic requirements are there for proper function of the vascular system?

A
  1. **slow flow **- to match diffusion-driven processes
  2. steady flow
  3. unidirectional flow
25
Q

How does the continuity equation change in bifurcating vessels?

A
  • when a vessel bifurcates, we must consider the total cross-sectional area of the two new vessels and the average velocity of each of the new branches
26
Q

How does static pressure changed as we travel from aortic SLV to right atrium?

A

a steady decrease from about 100 mmHg in aorta

27
Q

How does flow rate change throughout the vascular system?

A

Starts very high in aorta

Dips to lowest in arterioles/capillaries

Increases again in veins to just below arterial levels

28
Q

How does total cross sectional area change throughout the vascular system?

A

opposite of flow rate

starts out lowest in aorta/arteries (2.5 cm2)

increases to highest in capillaries (2500 cm2)

decreases to just above aortic level in veins (8 cm2)

29
Q

What is the Young-Laplace equation?

A

an equation explaining the relationship between pressure on the wall (from the blood within) and tension arising in the wall

30
Q

What are the hemodynamic implications of vascular elasticity?

A
  1. Potential Energy Storage - elastic fibers store potential energy of high pressure moments and release it when they contract and increase pressure
  2. Dampening of Pressure Pulses - ex: aortic pressure does not drop to potentially very low levels during diastole b/c elasticity maintains pressure
  3. Constant Flow Rate
31
Q

What are the 5 auxiliary factors affecting circulation?

A
  1. arterial elasticity
  2. venous valves
  3. muscle action - muscles push on veins to enhance venous return
  4. **negative intrathoracic pressure **- relative vacuum
  5. atrioventricular plane movement (up and down, venous suction)