Weedon ch 40 cutaneous non lymphoid

Question 1

cell that is derived from antigenically stimulated b lymphocytes

Answer 1

plasma cells

and Neuts and Eos - bone marrow

Question 2

life span of plasma cells

Answer 2

2-3 days

Question 3

most specific interleukin in eosinophil

Answer 3

IL-5

Question 4

most specific chemokine for eosinophil

Answer 4

eotaxin

Question 5

what eosinophilic body is present in the cytoplasm of plasma cells that displaces the nucleus in the periphery

Answer 5

russel bodies

Question 6

specific illness where Russel bodies are prominent

Answer 6

rhinoscleroma

Question 7

site of formation of Russel bodies

Answer 7

rough endoplasmic reticulum

Question 8

stain for the cytoplasm of plasma cells

Answer 8

PAS + diastase negative because of glycoprotein

Question 9

normal locations where there are plasma cells

Answer 9

1) LIPS AND MUCOUS MEMBRANES!!
2) face AND SCALP OF KERATOSIS AFTER CRYOTHERAPY,
3) OTHERS: posterior neck, mucous membrane, axillary, breast, anogenital, pretibial

Question 10

stains for plasma cells

Answer 10

CD79a, CD 38 (flow cytometry) and CD 138

Question 11

12 DISEASES with prominent plasma cells

Answer 11

1) syphilis
2) granuloma inguinale
30 yaws
4) chancroid
5) chronic folliculitis
6) erythema nodosum leprosum
7) necrobiosis lipoidica
8)nodular amyloidosis
90 syringocystadenoma papilliferum
10) kaposi
11) rhinoscleroma
120 subset of MF

Question 12

what cell is the diagnostic feature of a subset in castle man?

Answer 12

plasma cell

Question 13

plasma cells with higher nuclear and cytoplasmic rate and with prominent nucleoli

Answer 13

plasmoblasts

Question 14

what stain stains the cytoplasm of plasma cell as red

Answer 14

methyl green-pyronin stain

Question 15

plasmocytoma histopath

Answer 15

dense plasma cells with different maturation in reticular dermis and subq

Question 16

stain for plasmocytoma of multiple myeloma

Answer 16

cd79a
cd 138 ( syndical-1) - sensitive maker for cutaneous plastocytoma
CD117 postive
cytokeratin postive
CD45 negtive
CD20 - negative

Question 17

primary role of neutrophils

Answer 17

phagocytosis and collagenase release of enzymes

Question 18

primary role of eosinophils

Answer 18

killing parasites, tissue damage in hypersensitive reaction and related to edema

Question 19

result of plasmocytoma in kappa and lambda light chains

Answer 19

kappa - negative lambda is positive

Question 20

another term for poem syndrome

polyneuropathy, Organomegaly, endocrine,-protein skin lesions

Answer 20

crow-ukase

Question 21

inclusion body of plasma cell in aldenstrom macroglobinemia

Answer 21

dutcher body

Question 22

what stains for the granules of mast cells METACHROMATICALLY (2)

Answer 22

toluidine blue and giemsa

Question 23

what stains for the granules of mast cells ORTHOCHROMATICALLY ( mixture of blue and red)

Answer 23

alcian blue-safranin

Question 24

what stain for the granules of mast cells orange-red

Answer 24

enzymatic method (chloroacetate esterase

Question 25

which stain fails to stain mast cells when fixed with formalin

Answer 25

toluidine blue

Question 26

IHC for mast cells

Answer 26

cd117, cd 43, (leukocyte common antigen) cd 45, tryptase, cd 5, cd 25 cd 33 cd 68

Question 27

LOCATion of the body where mast cells are abundant

Answer 27

scrotum. | they are common on ACRALl than central

Question 28

Ilan and average mast cells and scan say makikita sa dermis?

Answer 28

7000 mast cells/mm3 in Spd and appendages. smaller silk sa mucosa and fewer granules

Question 29

saan mas Malawi ang mast cells? sa dark or sa Maputi?

Answer 29

sa dark skin

Question 30

where are mast cells derived from? and IHC

Answer 30

bone marrow. they. stain cD34

Question 31

what substances in mast cells cause pruritus flushing syncope vasoactive and smooth muscle contraction? (3) THEY ALSO PRODUCE HEPARIN

Answer 31

1) HISTAMINE 2) LEUKOTRIENE 3) PROSTAGLANDINE D2

Question 32

WHAT CELLS can secrete mediators without degranulation?

Answer 32

mast cells. they are involved in neuroinflamm diseases that are worsened by stress

Question 33

mast cell growth factor are produced by 2 cells?

Answer 33

keratinocytes and fibroblasts

Question 34

role of mast cell growth factor (3) | clue: that is why lesions of mast cell proliferation are hyper pigmented

Answer 34

1) mast cell proliferation 2) melanocyte proliferation 3) melanin pigment production

Question 35

mas T cells are present in what instances

Answer 35

wound healing keloid urticaria atopic lichen Plans myxedema scleroderma and storm of NF and behcet

Question 36

3 tumors with mast cells

Answer 36

1) mF 2) bcc 3) NF

Question 37

small solitary lesions with proliferation of mast cells

Answer 37

mast cell nevi

Question 38

size of mastocytoma

Answer 38

>3cm

Question 39

mastocytoma-junctional nevus is a collision tumor or incidental finding of the presence of the 2 tumors?

Answer 39

x- collision | check- incidental finding

Question 40

codon for mast cell (2)

Answer 40

560 and 816

Question 41

how to diagnose mastocytosis

Answer 41

1 major - >15 mast cells in the bone marrow plus 1 minor or 3 minors

Question 42

4 minor criteria for mastocytosis

Answer 42

1) > 25% atypical mast cells 2) stains cd2 cd 25 and cd117 3) detection in c-kit and codon 816 4) >20ng/ml serum tryptase

Question 43

most common involved tissue in systemic mastocytosis

Answer 43

bone marrow

Question 44

which inc can be used to stain for atypical mast cells

Answer 44

anti-tryptase

Question 45

which stain can be used to predict the systemic mastocytosis

Answer 45

cd 25