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Weedon dermpath > Weedon ch 40 cutaneous non lymphoid > Flashcards

Weedon ch 40 cutaneous non lymphoid Flashcards

dermpath exam

1
Q

cell that is derived from antigenically stimulated b lymphocytes

A

plasma cells

and Neuts and Eos - bone marrow

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2
Q

life span of plasma cells

A

2-3 days

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3
Q

most specific interleukin in eosinophil

A

IL-5

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4
Q

most specific chemokine for eosinophil

A

eotaxin

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5
Q

what eosinophilic body is present in the cytoplasm of plasma cells that displaces the nucleus in the periphery

A

russel bodies

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6
Q

specific illness where Russel bodies are prominent

A

rhinoscleroma

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7
Q

site of formation of Russel bodies

A

rough endoplasmic reticulum

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8
Q

stain for the cytoplasm of plasma cells

A

PAS + diastase negative because of glycoprotein

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9
Q

normal locations where there are plasma cells

A

1) LIPS AND MUCOUS MEMBRANES!!
2) face AND SCALP OF KERATOSIS AFTER CRYOTHERAPY,
3) OTHERS: posterior neck, mucous membrane, axillary, breast, anogenital, pretibial

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10
Q

stains for plasma cells

A

CD79a, CD 38 (flow cytometry) and CD 138

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11
Q

12 DISEASES with prominent plasma cells

A

1) syphilis
2) granuloma inguinale
30 yaws
4) chancroid
5) chronic folliculitis
6) erythema nodosum leprosum
7) necrobiosis lipoidica
8)nodular amyloidosis
90 syringocystadenoma papilliferum
10) kaposi
11) rhinoscleroma
120 subset of MF

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12
Q

what cell is the diagnostic feature of a subset in castle man?

A

plasma cell

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13
Q

plasma cells with higher nuclear and cytoplasmic rate and with prominent nucleoli

A

plasmoblasts

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14
Q

what stain stains the cytoplasm of plasma cell as red

A

methyl green-pyronin stain

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15
Q

plasmocytoma histopath

A

dense plasma cells with different maturation in reticular dermis and subq

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16
Q

stain for plasmocytoma of multiple myeloma

A 
cd79a
cd 138 ( syndical-1) - sensitive maker for cutaneous plastocytoma
CD117 postive
cytokeratin postive
CD45 negtive
CD20 - negative
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17
Q

primary role of neutrophils

A

phagocytosis and collagenase release of enzymes

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18
Q

primary role of eosinophils

A

killing parasites, tissue damage in hypersensitive reaction and related to edema

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19
Q

result of plasmocytoma in kappa and lambda light chains

A

kappa - negative lambda is positive

20
Q

another term for poem syndrome

polyneuropathy, Organomegaly, endocrine,-protein skin lesions

A

crow-ukase

21
Q

inclusion body of plasma cell in aldenstrom macroglobinemia

A

dutcher body

22
Q

what stains for the granules of mast cells METACHROMATICALLY (2)

A

toluidine blue and giemsa

23
Q

what stains for the granules of mast cells ORTHOCHROMATICALLY ( mixture of blue and red)

A

alcian blue-safranin

24
Q

what stain for the granules of mast cells orange-red

A

enzymatic method (chloroacetate esterase

25
Q

which stain fails to stain mast cells when fixed with formalin

A

toluidine blue

26
Q

IHC for mast cells

A

cd117, cd 43, (leukocyte common antigen) cd 45, tryptase, cd 5, cd 25 cd 33 cd 68

27
Q

LOCATion of the body where mast cells are abundant

A

scrotum.

they are common on ACRALl than central

28
Q

Ilan and average mast cells and scan say makikita sa dermis?

A

7000 mast cells/mm3 in Spd and appendages. smaller silk sa mucosa and fewer granules

29
Q

saan mas Malawi ang mast cells? sa dark or sa Maputi?

A

sa dark skin

30
Q

where are mast cells derived from? and IHC

A

bone marrow. they. stain cD34

31
Q

what substances in mast cells cause pruritus flushing syncope vasoactive and smooth muscle contraction? (3) THEY ALSO PRODUCE HEPARIN

A

1) HISTAMINE
2) LEUKOTRIENE
3) PROSTAGLANDINE D2

32
Q

WHAT CELLS can secrete mediators without degranulation?

A

mast cells. they are involved in neuroinflamm diseases that are worsened by stress

33
Q

mast cell growth factor are produced by 2 cells?

A

keratinocytes and fibroblasts

34
Q

role of mast cell growth factor (3)

clue: that is why lesions of mast cell proliferation are hyper pigmented

A

1) mast cell proliferation
2) melanocyte proliferation
3) melanin pigment production

35
Q

mas T cells are present in what instances

A

wound healing
keloid
urticaria
atopic lichen Plans myxedema scleroderma and storm of NF and behcet

36
Q

3 tumors with mast cells

A

1) mF
2) bcc
3) NF

37
Q

small solitary lesions with proliferation of mast cells

A

mast cell nevi

38
Q

size of mastocytoma

A

> 3cm

39
Q

mastocytoma-junctional nevus is a collision tumor or incidental finding of the presence of the 2 tumors?

A

x- collision

check- incidental finding

40
Q

codon for mast cell (2)

A

560 and 816

41
Q

how to diagnose mastocytosis

A

1 major - >15 mast cells in the bone marrow plus 1 minor or 3 minors

42
Q

4 minor criteria for mastocytosis

A

1) > 25% atypical mast cells
2) stains cd2 cd 25 and cd117
3) detection in c-kit and codon 816
4) >20ng/ml serum tryptase

43
Q

most common involved tissue in systemic mastocytosis

A

bone marrow

44
Q

which inc can be used to stain for atypical mast cells

A

anti-tryptase

45
Q

which stain can be used to predict the systemic mastocytosis

A

cd 25

Weedon dermpath (1 decks)

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