WBCs Flashcards
Infectious mononucleosis caused by… and causes…
Caused by EBV and CMV (less common)
Causes lymphocytic leukocytosis
Acute leukemia is when blast % is…
More than 20%
Auer rod bodies seen in…
AML
TdT seen in…
ALL
9,22 gene is know as…
Philadelphia chromosome/ BCR-ABL
Philedelphia chromosome seen in…
CML & B-ALL
Gene translocation in AML…
15-17 gene that disrupts RARA
Treatment of AML…
ATRA
Age in which AML, B-ALL & T-ALL is seen…
AML: 50-60
B-ALL: Children
T-ALL : Teenagers
Proliferation of naive B cells seen in… and mature B cells in…
CLL nakve
Hairy cell leukemia mature
Smudge cells seen in…
CLL
CLL involving lymph nodes is called…
Small lymphocytic lymphoma
Hypogammaglobulinemia seen in…
CLL
Positive TRAP test indicates…
Hairy cell leukemia
Basophilia seen in…
CML
First line treatment of CML is…
Imatinib
3 ways to differentiate CML from leukomoid reaction is…
CML is LAP -ve
Basophilia in CML
Philadelphia chromosome in CML
(Leukomoid reaction is increased granulocytes due to infection)
Jak2 mutation seen in…
Polycythemia vera & essential thrombocythemia
Hyperuricemia/gout seen in all myelodysplastic disorders except…cuz…
Essential thrombocythemia cuz platelets got no nucleus that’ll get turned over
Tear drop cells seen in…
Myelofibrosis
Painful vs painless lymphadenopathy causes…
Painful: acute infection
Painless: chronic infection, lymphoma
Gene translocation in follicular lymphoma…
14:18 BCL2 overexpression
Treatment of follicular lymphoma…
Rituximab
Gene translocation in mantle cell lymphoma is…
11:14
Which non hodgkin lymphoma is associated with hashimoto thyroiditis and sjogren syndrome and h pylori
Marginal cell lymphoma
MALToma is a subtype of…
Marginal cell lymphoma
Gene translocation in burkit lymphoma is…
8:14
Starry sky appearance seen in…
Burkit lymphoma
Diffuse large B cell lymphoma can arise from…
Follicular lymphoma
EBV associated with which lymphoma
Burkit
Reed sternberg cells seen..
Hodgkin lymphoma
Lacunar cells seen in which type of hodgkins lymphoma?
Nodular sclerosis subtype
Multiple myeloma is malignant proliferation of…
Plasma cells
Punched out lesions on vertebrae and skull seen in…
Multiple myeloma (osteoclastic)
Mutiple myeloma caused by proliferation of…
Plasma cells
Elevated immunoglobulin in MM is… which causes… which causes…
IgG which causes excess light chains which deposit on tissue and cause Primary AL amyloidosis and appear on urine as bense jones proteins (hematuria)
Clinical features of MM is due to its…. effect
Osteoclastic effect which causes “punched out lesion” bone pain, hgpercalcemia and increased fractures
Elevated IgG without osteoclastic symptims and light chain symptoms is called…
MGUS
