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Hematology > WBCs > Flashcards

WBCs Flashcards

1
Q

Infectious mononucleosis caused by… and causes…

A

Caused by EBV and CMV (less common)
Causes lymphocytic leukocytosis

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2
Q

Acute leukemia is when blast % is…

A

More than 20%

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3
Q

Auer rod bodies seen in…

A

AML

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4
Q

TdT seen in…

A

ALL

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5
Q

9,22 gene is know as…

A

Philadelphia chromosome/ BCR-ABL

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6
Q

Philedelphia chromosome seen in…

A

CML & B-ALL

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7
Q

Gene translocation in AML…

A

15-17 gene that disrupts RARA

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8
Q

Treatment of AML…

A

ATRA

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9
Q

Age in which AML, B-ALL & T-ALL is seen…

A

AML: 50-60
B-ALL: Children
T-ALL : Teenagers

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10
Q

Proliferation of naive B cells seen in… and mature B cells in…

A

CLL nakve
Hairy cell leukemia mature

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11
Q

Smudge cells seen in…

A

CLL

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12
Q

CLL involving lymph nodes is called…

A

Small lymphocytic lymphoma

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13
Q

Hypogammaglobulinemia seen in…

A

CLL

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14
Q

Positive TRAP test indicates…

A

Hairy cell leukemia

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15
Q

Basophilia seen in…

A

CML

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16
Q

First line treatment of CML is…

A

Imatinib

17
Q

3 ways to differentiate CML from leukomoid reaction is…

A

CML is LAP -ve
Basophilia in CML
Philadelphia chromosome in CML
(Leukomoid reaction is increased granulocytes due to infection)

18
Q

Jak2 mutation seen in…

A

Polycythemia vera & essential thrombocythemia

19
Q

Hyperuricemia/gout seen in all myelodysplastic disorders except…cuz…

A

Essential thrombocythemia cuz platelets got no nucleus that’ll get turned over

20
Q

Tear drop cells seen in…

A

Myelofibrosis

21
Q

Painful vs painless lymphadenopathy causes…

A

Painful: acute infection
Painless: chronic infection, lymphoma

22
Q

Gene translocation in follicular lymphoma…

A

14:18 BCL2 overexpression

23
Q

Treatment of follicular lymphoma…

A

Rituximab

24
Q

Gene translocation in mantle cell lymphoma is…

A

11:14

25
Q

Which non hodgkin lymphoma is associated with hashimoto thyroiditis and sjogren syndrome and h pylori

A

Marginal cell lymphoma

26
Q

MALToma is a subtype of…

A

Marginal cell lymphoma

27
Q

Gene translocation in burkit lymphoma is…

A

8:14

28
Q

Starry sky appearance seen in…

A

Burkit lymphoma

29
Q

Diffuse large B cell lymphoma can arise from…

A

Follicular lymphoma

30
Q

EBV associated with which lymphoma

A

Burkit

31
Q

Reed sternberg cells seen..

A

Hodgkin lymphoma

32
Q

Lacunar cells seen in which type of hodgkins lymphoma?

A

Nodular sclerosis subtype

33
Q

Multiple myeloma is malignant proliferation of…

A

Plasma cells

34
Q

Punched out lesions on vertebrae and skull seen in…

A

Multiple myeloma (osteoclastic)

35
Q

Mutiple myeloma caused by proliferation of…

A

Plasma cells

36
Q

Elevated immunoglobulin in MM is… which causes… which causes…

A

IgG which causes excess light chains which deposit on tissue and cause Primary AL amyloidosis and appear on urine as bense jones proteins (hematuria)

37
Q

Clinical features of MM is due to its…. effect

A

Osteoclastic effect which causes “punched out lesion” bone pain, hgpercalcemia and increased fractures

38
Q

Elevated IgG without osteoclastic symptims and light chain symptoms is called…

A

MGUS

Hematology (2 decks)

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