WBC Translocations

Question 1

t(12;21)

involves ETV6 and RUNX1

Answer 1

B cell acute lymphoblastic leukemia

(B-ALL)

Question 2

what translocation is most commonly seen in B cell acute lymphoblastic leukemia (B-ALL)?

Answer 2

t(12;21)

involves ETV6 and RUNX1

Question 3

t(14;18)

creates the BCL2/Ig heavy chain fusion protein

Answer 3

follicular lymphoma

Question 4

what translocation is most commonly associated with follicular lymphoma?

Answer 4

t(14;18)

creates the BCL2/Ig heavy chain fusion protein

Question 5

t(8;14)

involves MYC/IgH heavy chain

Answer 5

Burkitt lymphoma

Question 6

what translocations are most commonly seen in Burkitt lymphoma?

Answer 6

• t(8;14) - MYC/IgH heavy chain
• t(2;8) - MYC/Ig kappa light chain
• t(8;22) - MYC/Ig lambda light chain

Question 7

t(11;14)

involves cyclin D1 and IgH

Answer 7

mantle cell lymphoma

Question 8

what translocation is most commonly associated with mantle cell lymphoma?

Answer 8

t(11;14)

involves cyclin D1 and IgH

Question 9

t(8;21)

inv(16)

Answer 9

acute myeloid leukemia (AML)

Question 10

what mutations are most commonly seen in acute myeloid leukemia (AML)?

Answer 10

• t(8;21)
• inv(16)

Question 11

t(15;17)

Answer 11

acute promyelocytic subtype of acute myelogenous leukemia (AML)

Question 12

t(9;22) –> BCR-ABL fusion protein

Answer 12

chronic myelogenous leukemia (CML)

Question 13

what translocation is most commonly seen with chronic myelogenous leukemia (CML)?

Answer 13

t(9;22) –> BCR-ABL fusion protein