WBC Markers And Genetics

Question 1

Pre-B cells (Lymphoblastic)

Answer 1

CD34+, TdT, CD19, CD10, CD22, MPO-

Question 2

Pre T-Cell

Answer 2

CD34+, TdT, CD1a, CD2, CD5, CD7, MPO+

Question 3

Pre-T cell (Late)

Answer 3

CD34, TdT, CD3, CD4, CD8

Question 4

CLL/SLL

Answer 4

CD19, CD20, CD23, CD5, dim light chains

Question 5

Follicular Lymphoma

Answer 5

CD19, CD20, CD10, light chain, t(14;18) Bcl2

Question 6

Mantle Cell Lymphoma

Answer 6

CD19, CD20, CD5, bright light chain, t(11;14) CyclinD1

Question 7

Marginal Cell Lymphoma

Answer 7

CD19, CD20, light chain +

Question 8

Lymphoplasmalytic Lymphoma

Answer 8

Increase IgM -> Waldenstrom Macroglobulinemia, MYD88 mutation

Question 9

Hairy Cell Leukemia

Answer 9

CD19, CD20, CD11c, CD25, CD103, light chain, BRAF mutation

Question 10

Plasma Cell Neoplasms (Multiple Myeloma, MGUS, Plasmacytoma)

Answer 10

CD38, CD56, INTRACELLULAR light chain, CD19-, CD20-, CD45-

Question 11

DLBCL

Answer 11

CD19, CD20, CD10, ^Bcl6, +/- Bcl2

Question 12

Burkitt Lymphoma

Answer 12

CD19, CD20, CD10, light chain, Bcl6, cMYC t(8;14)

Question 13

Anaplastic Large Cell Lymphoma

Answer 13

ALK gene, 2p23

Question 14

Adult T-Cell Leukemia/Lymphoma

Answer 14

CD4+, CD7, HTLV-1 associated

Question 15

MF/SS

Answer 15

CD4+

Question 16

Large Granular Lymphocytic Leukemia

Answer 16

T or NK cell with Stat3 mutation

Question 17

Hodgkin (4 main types)

Answer 17

CD15, CD30, CD45-, B-, T-

Question 18

Hodgkin Nodular Lymphocyte Predominance

Answer 18

B+, CD45+, Bcl6, CD15-, CD30-

Question 19

Myeloblastic Leukemia

Answer 19

CD34, CD13, CD33, MPO+, Auer Rod+

Question 20

Monoblastic Leukemia

Answer 20

CD11b, CD14, HLA-DR, NSE+

Question 21

Langerhans Cell histiocytosis

Answer 21

CD1a, S-100, HLA-DR, Birbeck Granules