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Pathology Nakon > WBC, LN, SPLEEN, THYMUS > Flashcards

WBC, LN, SPLEEN, THYMUS Flashcards

1
Q

Dohle bodies- sky blu cytoplasmic puddles

A

Sepsis

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2
Q

Neoplasms in bone marrow. Tumor cells found in peripheral blood

A

Leukemia

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3
Q

Immature leukemia

A

Acute leukemia

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4
Q

Mature leukemia

A

Chronic leukemia

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5
Q

MC cancer of children

A

Acute lymphoblastic leukemia

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6
Q

T(12,21)

A

ALL

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7
Q

Leukemia that is most responsive to tx

A

ALL

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8
Q

Primary chemitherapeutic drug for ALL? Wwhat is its catastrphic SE

A

Asparaginase - pancreatitis

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9
Q

Leukemia with very low alk phos

A

CML

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10
Q
A

Chronic phase

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11
Q

10-19% myeloblast

A

Accelerated phase

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12
Q

> 20% myeloblast

A

Blast crisis

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13
Q

Solid focus of leukemia outside the bone

A

Chloroma

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14
Q

Distinctive needle like azurophilic granules

A

Auer rods

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15
Q

Primary chemotherapeutic drug for CML. SE?

A

Imatinib - flyid retention, CHF

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16
Q

Most common leukemia in the elderly

A

Chronic lymphocytic leukemia (CLL)

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17
Q

Increase in WBC count with left shift and high alk phos.

Usually caused by infection

A

Leukemoid reaction

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18
Q

Leukemia in 15-39 y. O

A

AML

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19
Q

Leukemia in 25-60 yo

A

CML

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20
Q

Reed sternberg cells

A

Hodgkins lymphoma

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21
Q

MC hodgkins lymphoma

A

Nodular sclerosis

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22
Q

Most common hepatopoietic malignancy

A

Non hodgkins lymphoma

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23
Q

Most common form of indolent NOn hodgskins lymphoma

A

Follicular lymphoma

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24
Q

T(14:18

A

Follicular lymphoma

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25
Q

MC NHL

A

Diffuse large cell lymphoma

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26
Q

Starry sky pattern. Comon in africans

A

Burkitts lymphoma

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27
Q

T(11;14)

A

Mantle lymphoma - poor prognosis

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28
Q

Neoplasm of CD4 + Tcell

A

Adult t cell lymphoma

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29
Q

T(15;17)

A

APML

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30
Q

t(9;22)

A

CML

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31
Q

t(8:14)

A

Burkitt lymphoma

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32
Q

Diffuse erythema and scaling of the entire body surhace

A

Sezary syndrome

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33
Q

MC and most deadly plasma cell neoplasm

A

Multiple myeloma

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34
Q

Defeerentiate waldenstroms macroglobulinemia from multiple myeloma

A

No lytic lesion in waldenstrom

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35
Q

Differentiate monoclonal gammopathy of endetermined significance MGUS FROM MULTIPLE MYELOMA

A

MGUS IS ASYMPTOMATIC

36
Q

Teardrop cells or dacryocytes

A

Primary myelofibrosis

37
Q

Tx for primary myelofibrosis

A

Bone marrow transplant

38
Q

Birbeck granules ( tennis racket like appearance)

A

Langerhans cell histiocytes

39
Q

Small yellow brown, brown or rust coloured foci in speel

A

Gandy gamna nodules

40
Q

Swirling pattern of spindle shaped cells associated with myasthenia gravis

A

Thymoma

41
Q

Differentiate extravascular hemolysis from intravascular hemolysis

A

Extravascular causes splenomegaly

42
Q

Hemolytic anemia

A

Normocytic, normochromic

43
Q

MCC of IDA

A

GI bleeding

44
Q

Tx for hereditary spherocytosis

A

Splenectomy

45
Q

Small dark nuclear remnants present in RBCs of asplenic patiens

A

Howell-jolky bodies

46
Q

Episodic hemolysis in G6PD deficuency

A

Drugs: antimalarials, sulfonamides, nitofurantoins

Food: fava beans

47
Q

G6PD is the rate limiting step in which biochemical pathway

A

Pentose phosphate pathway

Reduce NADP-NAPDH

48
Q

Why are infants with sickle cell disease asumptomatic until 2-4 months of age?

A

Due to high amounts of fetal hemoglobin (Hbf)

49
Q

Best initial diagnostic test for sickle cell anemia

A

Peipheral blood smear

50
Q

Gold standard fir sickle cell anemia

A

Hemoglobin electrophoresis

51
Q

DOC for sickle cell anemia

A

Hydroxyurea (increase Hbf)

52
Q

Most severe form of a- thalassemia

A

Hydrops fetalis

53
Q

Anemia in thalassemia

A

Microcytic,hypochromic

54
Q

Decrease synthesis of adlut hemoglobin

A

Thalassemia

55
Q

Primary tx for hemochromatosis

A

Phlebotomy

56
Q

Hemochromatosis that does not respond to phlebotomy

A

Deferoxamine

57
Q

Leading cause of death in paroxysmal nocturnal hemoglobinuria

A

Thrombosis

58
Q

Caused by trauma to RBC IN INDIVIDUALS WITH cardiac valve prosthesis

A

Microangiopathic hemolytic anemia

59
Q

Vit B 12 or folate deficiency

A

Megaloblastic anemia

60
Q

Which oarasit infection can lead to megaloblastoc anemia?

A

Dyphyllibothrium latum

61
Q

Schilling test

A

Pernicious anemia

62
Q

Most common nutritional disorder in the world

A

Iron defiency anemia

63
Q

Which parasite infection can lead to microcytic hypochromic anemia

A

Hookworms ( necator, ancylostoma)

Albendazole

64
Q

Iron deficiency anemia

A

Microcytic hypochromic anemia

65
Q

Esophageal webs, microcytic hypochromatic anemia, atrophic glossitis

A

Plummer- vinson syndrome

66
Q

IDA in elderly may be due to

A

Colorectal ca

67
Q

Chronic primary hematopoietic failure and pancytopenia

A

Aplastic anemia

68
Q

Chemical exposure which causes aplastic anemia

A

Benzene

69
Q

Antiobiotic which causes aplastic anemia

A

Chloamphenicol

70
Q

Aplastic anemia

A

Normocytic, normochromic

71
Q

Deifferentiate aplastic anemia from myelodysplastic syndrome

A

In MDS , BM is hypercellular. In aplastic anemia, BM is hypocellular

72
Q

Most feared complication ITP

A

Intracranial bleeding

73
Q

That that cause neutropenia

A

Aminopyrine, PTU, chloramphenicol

74
Q

Decreased gp1b leads to defective platelet adhesion. Decreased platelet count

A

Bernard soulier syndrome

75
Q

Decreased gp IIb-IIIa leads to defective platelet aggregation. Normal platelet count

A

Glanzmann’s thrmbathenia

76
Q

MC inherent bleeding disorder

A

Von willebrand disease

77
Q

Tx for vwd

A

Desmopressin

Factor VIII and vWF

78
Q

MC hereditary disease associated with life threatening bleeding due to factor VIII deficinecy

A

Hemophilia A

79
Q

Tx for hemophilia A

A

Factor VIII precipitate

80
Q

Christmas disease

A

Hemophilia B.

Factor IX concentrate

81
Q

Sever meningococcemia

A

Waterhouse- friderichsen syndrome

82
Q

Postpartum pituitary necrosis

A

Sheehan syndrone

83
Q

Most specific test for DIC?

A

D-dimer

84
Q

Dx test for pulmonary embolism

A

D- dimer

85
Q

Dx test for herpes

A

Tzank smear

86
Q

Cause of herpes labialis

A

HSV-1

87
Q

95% of cancers if the head and neck

A

Squamous cell carcinoma

Pathology Nakon (9 decks)

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