WBC, LN, SPLEEN, THYMUS

Question 1

Dohle bodies- sky blu cytoplasmic puddles

Answer 1

Sepsis

Question 2

Neoplasms in bone marrow. Tumor cells found in peripheral blood

Answer 2

Leukemia

Question 3

Immature leukemia

Answer 3

Acute leukemia

Question 4

Mature leukemia

Answer 4

Chronic leukemia

Question 5

MC cancer of children

Answer 5

Acute lymphoblastic leukemia

Question 6

T(12,21)

Answer 6

ALL

Question 7

Leukemia that is most responsive to tx

Answer 7

ALL

Question 8

Primary chemitherapeutic drug for ALL? Wwhat is its catastrphic SE

Answer 8

Asparaginase - pancreatitis

Question 9

Leukemia with very low alk phos

Answer 9

CML

Answer 10

Chronic phase

Question 11

10-19% myeloblast

Answer 11

Accelerated phase

Question 12

> 20% myeloblast

Answer 12

Blast crisis

Question 13

Solid focus of leukemia outside the bone

Answer 13

Chloroma

Question 14

Distinctive needle like azurophilic granules

Answer 14

Auer rods

Question 15

Primary chemotherapeutic drug for CML. SE?

Answer 15

Imatinib - flyid retention, CHF

Question 16

Most common leukemia in the elderly

Answer 16

Chronic lymphocytic leukemia (CLL)

Question 17

Increase in WBC count with left shift and high alk phos.

Usually caused by infection

Answer 17

Leukemoid reaction

Question 18

Leukemia in 15-39 y. O

Answer 18

AML

Question 19

Leukemia in 25-60 yo

Answer 19

CML

Question 20

Reed sternberg cells

Answer 20

Hodgkins lymphoma

Question 21

MC hodgkins lymphoma

Answer 21

Nodular sclerosis

Question 22

Most common hepatopoietic malignancy

Answer 22

Non hodgkins lymphoma

Question 23

Most common form of indolent NOn hodgskins lymphoma

Answer 23

Follicular lymphoma

Question 24

T(14:18

Answer 24

Follicular lymphoma

Question 25

MC NHL

Answer 25

Diffuse large cell lymphoma

Question 26

Starry sky pattern. Comon in africans

Answer 26

Burkitts lymphoma

Question 27

T(11;14)

Answer 27

Mantle lymphoma - poor prognosis

Question 28

Neoplasm of CD4 + Tcell

Answer 28

Adult t cell lymphoma

Question 29

T(15;17)

Answer 29

APML

Question 30

t(9;22)

Answer 30

CML

Question 31

t(8:14)

Answer 31

Burkitt lymphoma

Question 32

Diffuse erythema and scaling of the entire body surhace

Answer 32

Sezary syndrome

Question 33

MC and most deadly plasma cell neoplasm

Answer 33

Multiple myeloma

Question 34

Defeerentiate waldenstroms macroglobulinemia from multiple myeloma

Answer 34

No lytic lesion in waldenstrom

Question 35

Differentiate monoclonal gammopathy of endetermined significance MGUS FROM MULTIPLE MYELOMA

Answer 35

MGUS IS ASYMPTOMATIC

Question 36

Teardrop cells or dacryocytes

Answer 36

Primary myelofibrosis

Question 37

Tx for primary myelofibrosis

Answer 37

Bone marrow transplant

Question 38

Birbeck granules ( tennis racket like appearance)

Answer 38

Langerhans cell histiocytes

Question 39

Small yellow brown, brown or rust coloured foci in speel

Answer 39

Gandy gamna nodules

Question 40

Swirling pattern of spindle shaped cells associated with myasthenia gravis

Answer 40

Thymoma

Question 41

Differentiate extravascular hemolysis from intravascular hemolysis

Answer 41

Extravascular causes splenomegaly

Question 42

Hemolytic anemia

Answer 42

Normocytic, normochromic

Question 43

MCC of IDA

Answer 43

GI bleeding

Question 44

Tx for hereditary spherocytosis

Answer 44

Splenectomy

Question 45

Small dark nuclear remnants present in RBCs of asplenic patiens

Answer 45

Howell-jolky bodies

Question 46

Episodic hemolysis in G6PD deficuency

Answer 46

Drugs: antimalarials, sulfonamides, nitofurantoins Food: fava beans

Question 47

G6PD is the rate limiting step in which biochemical pathway

Answer 47

Pentose phosphate pathway Reduce NADP-NAPDH

Question 48

Why are infants with sickle cell disease asumptomatic until 2-4 months of age?

Answer 48

Due to high amounts of fetal hemoglobin (Hbf)

Question 49

Best initial diagnostic test for sickle cell anemia

Answer 49

Peipheral blood smear

Question 50

Gold standard fir sickle cell anemia

Answer 50

Hemoglobin electrophoresis

Question 51

DOC for sickle cell anemia

Answer 51

Hydroxyurea (increase Hbf)

Question 52

Most severe form of a- thalassemia

Answer 52

Hydrops fetalis

Question 53

Anemia in thalassemia

Answer 53

Microcytic,hypochromic

Question 54

Decrease synthesis of adlut hemoglobin

Answer 54

Thalassemia

Question 55

Primary tx for hemochromatosis

Answer 55

Phlebotomy

Question 56

Hemochromatosis that does not respond to phlebotomy

Answer 56

Deferoxamine

Question 57

Leading cause of death in paroxysmal nocturnal hemoglobinuria

Answer 57

Thrombosis

Question 58

Caused by trauma to RBC IN INDIVIDUALS WITH cardiac valve prosthesis

Answer 58

Microangiopathic hemolytic anemia

Question 59

Vit B 12 or folate deficiency

Answer 59

Megaloblastic anemia

Question 60

Which oarasit infection can lead to megaloblastoc anemia?

Answer 60

Dyphyllibothrium latum

Question 61

Schilling test

Answer 61

Pernicious anemia

Question 62

Most common nutritional disorder in the world

Answer 62

Iron defiency anemia

Question 63

Which parasite infection can lead to microcytic hypochromic anemia

Answer 63

Hookworms ( necator, ancylostoma) Albendazole

Question 64

Iron deficiency anemia

Answer 64

Microcytic hypochromic anemia

Question 65

Esophageal webs, microcytic hypochromatic anemia, atrophic glossitis

Answer 65

Plummer- vinson syndrome

Question 66

IDA in elderly may be due to

Answer 66

Colorectal ca

Question 67

Chronic primary hematopoietic failure and pancytopenia

Answer 67

Aplastic anemia

Question 68

Chemical exposure which causes aplastic anemia

Answer 68

Benzene

Question 69

Antiobiotic which causes aplastic anemia

Answer 69

Chloamphenicol

Question 70

Aplastic anemia

Answer 70

Normocytic, normochromic

Question 71

Deifferentiate aplastic anemia from myelodysplastic syndrome

Answer 71

In MDS , BM is hypercellular. In aplastic anemia, BM is hypocellular

Question 72

Most feared complication ITP

Answer 72

Intracranial bleeding

Question 73

That that cause neutropenia

Answer 73

Aminopyrine, PTU, chloramphenicol

Question 74

Decreased gp1b leads to defective platelet adhesion. Decreased platelet count

Answer 74

Bernard soulier syndrome

Question 75

Decreased gp IIb-IIIa leads to defective platelet aggregation. Normal platelet count

Answer 75

Glanzmann's thrmbathenia

Question 76

MC inherent bleeding disorder

Answer 76

Von willebrand disease

Question 77

Tx for vwd

Answer 77

Desmopressin | Factor VIII and vWF

Question 78

MC hereditary disease associated with life threatening bleeding due to factor VIII deficinecy

Answer 78

Hemophilia A

Question 79

Tx for hemophilia A

Answer 79

Factor VIII precipitate

Question 80

Christmas disease

Answer 80

Hemophilia B. Factor IX concentrate

Question 81

Sever meningococcemia

Answer 81

Waterhouse- friderichsen syndrome

Question 82

Postpartum pituitary necrosis

Answer 82

Sheehan syndrone

Question 83

Most specific test for DIC?

Answer 83

D-dimer

Question 84

Dx test for pulmonary embolism

Answer 84

D- dimer

Question 85

Dx test for herpes

Answer 85

Tzank smear

Question 86

Cause of herpes labialis

Answer 86

HSV-1

Question 87

95% of cancers if the head and neck

Answer 87

Squamous cell carcinoma