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Pathology - Marcel > Wbc, LN, Spleen Thymus > Flashcards

Wbc, LN, Spleen Thymus Flashcards

1
Q

How to compute for normal cellularity of bone marrow.

A

100-age

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2
Q

Cause for dose related neutropenia

A

Alkylating agents

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3
Q

Lifespan of neutrophils

A

1-2 days

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4
Q

Produces hypercellular marrow but has blood component production problem

A

Mds and megaloblastic anemia

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5
Q

Type of leukocytosis seen in mds

A

Basophilic

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6
Q

Toxic granules seen in leukocytosis due to severe sepsis

A

Dohle bodies

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7
Q

Tests to differentiate leukemoid reaction from cml

A

Leukocyte alkaline phosphatase and crp. Elevated in leukemoid

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8
Q

Drugs that cause neutropenia

A

Aminopyrine, ptu, chloramphenicol, sulfa drugs, phenylbutazine

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9
Q

Swollen, gray-red and engorged lymph nodes

A

Acute lymph adenitis

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10
Q

Proliferating blast-like b cells seen in follicular hyperplasia

A

Centroblasts

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11
Q

B cells with cleaved nuclear contours

A

Centrocytes

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12
Q

Phagocytic macrophages containing the nuclear debris of b cells

A

Tingible body macrophages

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13
Q

Type of lymph adenitis seen in breast cancer

A

Sinus histiocytosis

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14
Q

Most common cancer in children

A

All

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15
Q

most common all antigen

A

CALLA or cd 10

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16
Q

Translocation on ALL

A

T 12:21

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17
Q

What chemi agent is used or ALL and what is its catastrophic side effect

A

Asparaginas Pancreatitis

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18
Q

Vehicle used to deliver chemo for ALL to cns sanctuary sites

A

Ommaya shunt

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19
Q

Distinctive needle like azurophillic granules seen in aml and apml

A

Auer rods

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20
Q

Antigen profile of aml

A

Mpo cd 33 and cd 34 positive

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21
Q

Translocation seen in apml

A

T 15:17

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22
Q

Treatment for apml

A

All trans retinoic acid

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23
Q

Translocation in aml

A

T 9:22

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24
Q

Scattered macrophages with abundant wrinkled green blue cytoplasm seen in cml

A

Sea-blue histiocytes

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25
Q

Asymptomatic phase of cml

A

Chronic phase

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26
Q

Phase of cml where disease is progressing. 10-19% myeloblasts in bone marrow

A

Accelerated phase

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27
Q

Final phase of cml. >20% myeloblast in bm

A

Blast crisis

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28
Q

Treatment for cml. side effect

A

Imatinib. Fluid retention. Chf

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29
Q

Absolute lymphocyte count of cll

A

> 4000

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30
Q

Absolute lymphocyte count of sll

A
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31
Q

Most commob leukemia of adults and elderly

A

CLL

32
Q

Small lymphocytes disrupted in the process of making smears. Seen in CLL

A

Smudge cells

33
Q

Transformation of CLL into diffuse large b cell lymphoma

A

Richter syndrome

34
Q

Hairy cell leukemia is stained using

A

Tartrate resistant acid phosphatase (trap)

35
Q

Main neoplastic cell in hodgkins lymphoma

A

Reed sternberg cell

36
Q

Involvement of mesenteric nodes and the waldeyer’s ring is seen in

A

Non hodgkins lymphoma

37
Q

Antigenic profile of hodgkins lymphoma

A

Positive for cd 15 and 30

38
Q

Type hodgkins lymphoma with poorest prognosis.

A

Leukocyte depleted

39
Q

Type of hodgkins lymphlma with best prognosis

A

Lymphocyte rich

40
Q

Type of hodgkins lymphoma related to ebv infection

A

Lymphocyte depleted > mixed cellularity > lymphocyte rich

41
Q

Most common type of hodgkins lymphoma associates with formation of collagen bands

A

Nodular sclerosis

42
Q

Type of hodgkins that does not stain with cd 15 and 30

A

Lymphocyte predominant

43
Q

Paraneoplastic syndrome seen in patients with hodgkins lymphoma who drink alcohol

A

Painful lymph nodes

44
Q

Most common hematopoetic malignancy

A

NHL

45
Q

Most common form of NHL

A

DLBCL

46
Q

T 14:18

A

Follicullar lymphoma

47
Q

Burkitts lymphoma is associated with translocation of what gene.

A

C myc gene

48
Q

Cellular pattern seen in burkitts lymphoma

A

Starry night pattern

49
Q

Infection associated woth burkitts lymphoma

A

Ebv

50
Q

High levels of cyclin D1 is expressed in

A

Mantle cell lymphoma

51
Q

Translocation in mantle cell lymphoma

A

T 11:14

52
Q

Malignancy of cd4+ t cells

A

Adult t cell lymphoma

53
Q

Adult t cell lymphoma is caused by

A

Htlv -1

54
Q

Clover leaf or flower cells are seen in what lymphoma

A

Adult t cell lymphoma

55
Q

Cd 4 cells forming band like aggregates seen in cutaneous t cell lymphoma are called

A

Sezary-lutzner cells

56
Q

Diffuse erythema and scaling of entire body seen in mycosis fungiodes

A

Sezary syndrome

57
Q

Aggressive nodular eruptive variant of mycosis fungiodes ( CTCL)

A

Mycosis fungiodes d’emblee

58
Q

Pautriers microabscesses are seen in

A

Cutaneous t cell lymphoma

59
Q

Excess light or heavy chain proteins secreted by neoplastic plasma cells

A

Bence jones proteins

60
Q

Destructive plasma cell tumors involving axial

Skeleton

A

Plasmacytoma

61
Q

Multiple grapelike cytoplasmic droplets seen in multiple myeloma

A

Mott cells

62
Q

Blue globular nuclear inclusions seen in multiple myeloma

A

Dutcher bodies

63
Q

M proteins causes rbcs in pbs to stick in linear arrays by altering the zeta potential in rbcs

A

Rouleaux conformation

64
Q

Which monoclonal gammopathy has no neoplasm involvement

A

MGUS

65
Q

Erythroblasts with iron laden mitochondria seen in mds

A

Ringed sideroblasts

66
Q

Neutrophils with only 2 lobes seen in mds

A

Pseudo pelger huet cells

67
Q

Megakaryocytes with single nuclear lobes seen in mds

A

Pawn ball megakaryocytes

68
Q

Mutation seen in polycythemia vera, essential thrombocytosis, and myelofibrosis

A

Jak2 mutation

69
Q

Treatment of polycythemia vera

A

Phlebotomy

70
Q

Polycythemia vera has a 2 percent chance to transform to

A

AML

71
Q

Hallmark of this disease is development of obliterative marrow fibrosis

A

Primary myelofibrosis

72
Q

Premature release of nucleated erythroid and early granulocyte progenitors seen in primary myelofibrosis

A

Leukoerythroblastosis

73
Q

Teardrop cells are seen in what disease

A

Primary myelofibrosis

74
Q

Pentalimar tubules seen in langerhans cell histiocytosis with a tennis racket appearance

A

Birbeck granules

75
Q

Anemia seen in primary myelofibrosis

A

Normocytic normochromic

76
Q

Small yellow brown foci called gandy gamma nodules are seen in

A

Congestive splenomegaly

77
Q

Paraneoplastic syndrome seen in thymoma

A

Pure red cell aplasia

Pathology - Marcel (2 decks)

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