WBC Disorders (Sloka) penias/philias

Question 1

Neutrophilia

Answer 1

Infections - appendicitis
Sterile inflammations - AMI
Drug’s - corticosteroids, G-CSF, Lithium
Stress - labor

Baker: Ketoacidosis,

Question 2

Basophilia

Answer 2

CML

Question 3

Neutropenia

Answer 3

Aplastic anemia
Immune destruction - SLE
Chemotherapy
Septic shock
B12/Flolate deficiency

Drugs (Baker): Methotrexate, sulfonamides, phenytoin, methimazole.

Question 4

Eosinophilia

Answer 4

Pah! Eos!

Polyarteritis nodosa
Addison’s disease 
Hodgkin’s disease
Type I hypersensitivity (allergies)
Parasitic infestation

Baker: RA, Adrenal insufficiency, HIV, Malignancy (CML, Lung, Ovarian).

Question 5

Infectious mononucleosis findings?

Answer 5

Generalized TENDER lymphadenopathy 
Ampicillin Rash
Hepatosplenomegaly
Extreme fatigue
Exudative tosillitis
Fever
Sore throat

Question 6

Lymphocytosis

Answer 6

Viral infections
Whooping cough
Graves Disease
Phenytoin (neutropenia)

Question 7

Corticosteroids Causes?

Answer 7

Neutrophilia
Eosinopenia
Lymphopenia

Question 8

Pathogenesis of mono?

Answer 8

EBV.
Infects B cells (CD21) T cells helps to kill the infected B cells.

T cells are atypical.

Question 9

Lab results for someone with mono?

Answer 9

+ atypical lymphocytes
+ heterophile test
+ anti-viral capsid/nuclear antigen antibodies
increased serum transaminases (infects liver)
possible hepatosplenomegaly

SHOULD NOT play sports bc of spleen rupture risk!

Question 10

Lymphopenia

Answer 10

HIV
radiation
AI destruction
corticosteroids

Question 11

Monocytosis

Answer 11

Malignancy

Chronic infection/inflammation

Question 12

Graves disease.

Answer 12

Lymphopenia