WBC Disorders

Question 1

Causes of dry tap

Answer 1

Aplastic anemia
Myelofibrosis
Hairy cell leukemia
AML M7

Question 2

Causes of massive splenomegaly

Answer 2

Malaria
Kala azar
CML
Polycythemia vera
Gauchers disease
Myelofibrosis
Hairy cell leukemia

Question 3

Exception criteria for acute leukemia

Answer 3

t(15:17)
t(8:21)
Inv 16

Question 4

Myeloblast markers
Markers for B ALL
Markers for T ALL

Answer 4

CD 13, CD33, CD 117, MPO+
CD19 CD20 CD22 PAX5 TdT
CD1 CD2 CD3 CD5 CD7

Question 5

Hand mirror cells
Arbiskov cells
Pseudogaucher cells
Tear drop cells

Answer 5

ALL
Monocyte in chloroma (AML)
Bone marrow aspirate in AML
Myelofibrosis

Question 6

Coffee bean nuclei

Answer 6

Langerhans cell histiocytosis (BM biopsy)
Brunner tumor
Granulosa cell tumor of ovary
Papillary carcinoma of thyroid
Chondroblastoma

Question 7

BRFV600E mutation

Answer 7

Langerhans cell histiocytosis
Hairy cell leukemia
Papillary carcinoma of thyroid
Pilocytic astrocytoma

Question 8

Tennis raket appearance and birkeck granules on EM
Fried egg appearance
Starry sky appearance
Smudge cells
Reed sternberg cell

Answer 8

Langerhans cell histiocytosis
Hairy cell leukemia and oligodendroglioma
Burkitt lymphoma
CLL
Hodgkins lymphoma

Question 9

Bm aspirate findings in Multiple myeloma

Answer 9

Flame cell
Morula cell
Russell body
Dutcher body

Question 10

Hand Schuller Christian disease

Answer 10

Langerhans cell histiocytosis
Diabetes insipidus
Exophthalmos
Calvaroan bone defect

Question 11

JAK2V617F mutation

Answer 11

All myeloproliferative diseases except CML

Question 12

Markers for Hodgkins lymphoma

Answer 12

Classical: CD15 and CD30
Non classical: CD20, BCL6 and EMA

Question 13

Markers for CLL
Mutation in CLL

Answer 13

CD5 CD23 CD200
Del of 11q/13q/17q and trisomy 12

Question 14

Markers:
HCL
Follicular lymphoma
Mantle cell lymphoma
Multiple myeloma
LCH

Answer 14

Annexin A1, CD25,11c and 103
BCL2
CyclinD1, CD5, SOX11
Syndecan1, CD56
Langerin, S100, CD1a