WBC Flashcards
1
Q
M0
A
Undifferentiated AML
2
Q
M1
A
AML without maturation
3
Q
M2
A
AML with maturation <–AML with t(8;21) <WHO></WHO>
4
Q
M3
A
Acute PromyelocyticLeukemia,
5
Q
M3m
A
Microgranular, PromyelocyticLeukemia
6
Q
M4
A
Acute Myelomonocytic Leukemia
7
Q
M5
A
Acute MonocyticLeukemia
8
Q
M6
A
Erythroleukemia(DiGuglielmo’s)
9
Q
M7
A
MegakaryoblasticLeukemia
10
Q
M4Eo
A
Acute myelomonocyticleukemia with eosinophilia
11
Q
M5a
A
Acute monoblasticleukemia, poorly differentiated
12
Q
M5b
A
Acute monoblasticleukemia, with differentiation
13
Q
Neutrophil
A
pink to tan with violet or lilac
granules
14
Q
Eosinophil
A
bright orange refractile granules
15
Q
Charcoat-Leyden crystals
A
Found hexagonal bipyramidal crystals are composed of lysophospholipase localized in the cytoplasm of eosinophils
16
Q
Charcoat-Leyden crystals
A
Formed when there is an intense or prolonged eosinophilic inflammatory reaction
17
Q
Thorn Test:
A
a test to measure adrenocortical function
18
Q
Basophil
A
NUCLEUS:Clover-leaf like
CYTOPLASM: purple-black granules that
covers the nucleus
19
Q
Monocytes
A
round, oval, kidney shaped horseshoe-shaped, indented or folded with a lacelike or stingy chromatin pattern
CYTOPLASM: blue-gray, with fine azure granules
20
Q
Lymphocytes
A
scant basophilic cytoplasm (light sky blue)
Robin’s blue egg cytoplasm
21
Q
Downey Cells
A
Any of the several atypical lymphocytes seen in infectious mononucleosis
22
Q
Downey Cells
A
Ballerina Skirt Appearance; flared pattern cytoplasm with ends called scalloping which scallops nearby red blood cells
23
Q
AML
A
most common type of leukemia in children younger than 18 months of age
24
Q
Chloroma
A
Iocalized tumor masses consisting of myeloblasts; Produces a green appearance if the tissue is cut
25
Auer rods
Also called “faggot cells” which means “bunch of sticks”
26
AML
Thrombocytopenia
Anemia (normocytic normochromic)
27
Acute Promyelocytic Leukemia
most aggressive of acute leukemia
28
AML with t(15;17) in WHO classification
Acute Promyelocytic Leukemia (FAB M3)
29
Disseminated intravascular coagulation (DIC) is most often associated
Acute Promyelocytic Leukemia (FAB M3)
30
referred to as Naegelitype monocyticleukemia
Acute Myelomonocytic Leukemia (FAB M4)
31
AML with inv(16) in WHO classification at risk of leukostasis development
Acute Myelomonocytic Leukemia (FAB M4)
32
a pathological finding of slightly dilated, thin- walled vessels filled with leukemic cells.
Leukostasis
33
proliferation of both immature granulocytic
and erythrocytic cell types
Erythemicmyelosisor Di Guglielmo syndrome
34
most common cancer in children (L1)
Acute Lymphoblastic Leukemia
35
Terminal deoxynucleotidy ltransferase(TdT)
positive
common ALL antigen (cALLA) is found on the
surface of lymphoblasts in 70% of patients
Acute Lymphoblastic Leukemia
36
FAB CLASSIFICATION OF ALL: Small homogeneous blasts; mostly in children
L1
37
FAB CLASSIFICATION OF ALL
Large heterogeneous blasts; mostly in adults
L2
38
“Burkitttype ” large basophilic B-cell blasts with vacuoles, t(8;14) alteration is common. Frequently a “starry-sky” pattern of admixed histiocytes
L3
39
most common form of leukemia in adults
CLL
40
strong acid phosphatase reaction that is not
inhibited by tartaric acid or tartrate-resistant acid phosphatase (TRAP) stain
Hairy Cell Leukemia
41
marked degree of rouleaux formation
Multiple Myeloma
42
Produce multiple tumors, which appear on a radiograph as multiple punched-out osteoporotic lesions
Multiple Myeloma
43
a malignancy of the lymphoplasmacytoidcells, which manufacture IgM.
Waldenstrom Macroglobulinemia
44
characterized by the presence of Reed- Sternberg cells
Hodgkin type
45
a large multinucleated cell resembling an “owl’s eye seen in Hodgkin lymphoma
46
leukemic phase of cutaneous T-cell lymphoma, mycosis fungoides
Sezary Syndrome
47
Rare atypical mononuclear cells with
cerebriform nuclei
Sezarycells
48
TRAP +; pancytopenia
HL
49
an MPN that originates in an abnormal pluripotent bone marrow stem cell and is consistently associated with the BCR-ABL 1 fusion gene located in the Philadelphia chromosome
CML
50
reciprocal translocation of DNA between chromosomes 9 and 22 (t9q:22q)
Philadelphia chromosome
51
an absolute increase in red cell mass, leukocytosis, and thrombocytosis.
Polycythemia Vera
52
characterized by mutation of Janus 2 kinase,
JAK2 V617F
Polycythemia Vera
53
a clonal myeloproliferative disorder primarily affecting the megakaryocytic lineage with the principal manifestation of sustained thrombocytosis
Essential Thrombocythemia
54
disorders in which apoptosis predominates, hematopoiesis is ineffective, and cytopenias occur
Myelodysplastic syndromes
55
giant hypogranular platelets; pseudo-Pelger-Huët
Myelodysplastic Syndromes
56
Mature ones with a kidney-shaped or lobulated nucleus and vacuolated, basophilic, foamy cytoplasm
type I downey
57
Plasmacytoid nuclei with less vacuolated and basophilic cytoplasm
type ii downey
58
Binucleated lymphocytes indicates
lymphocytic leukemia or
leukosarcoma
59
Nucleus is notched, lobulated, and cloverleaf- like; indicates CLL (Chronic Lympogenous Leukemia)
Reider Cells
60
Seen in Niemann-Pick disease, Tay-Sachs disease, Hurley syndrome, and Burkitt lymphoma
Vacuolated Lymphocytes
61
smudge cells are usually seen in
CLL
62
basket cells
Granulocytic smudge cells
63
Antigen markers for t cells
cd2 and cd3
64
antigen markers for b cells
cd19 & cd20
65
HSC antigen narkers
cd34 & 45
66
an exaggerated response to infections and inflammation
Leukomoid reaction
67
Immature white cells immature red cells and platelet abnormalities seen in peripheral smear
Leukoerythroblastic picture
68
characterized by pale blue inclusions resembling Döhle bodies in neutrophils
May-Hegglin Anomaly
69
Purple red; seen in patients with Hurler, Hunter,and Maroteaux-Lamy types of genetic
mucopolysaccharidosis; Gargoylism
Alder-Reilly Anomaly
70
spectacle-like (“pince-nez”) morphology
Pelger-Huet Anomaly
71
Found in cases of granulocytic leukemia, myedysplastic and some myeloproliferative disorders, and some infections, and after exposure to certain drugs
Pseudo or Acquired Pelger-Huet anomaly
72
A type of WBC morphologic alterations showing a neutrophil nucleus with axial symmetry (mirror image) and is acquired in malignancies and chemotherapy
Twinning
73
Partial oculocutaneous albinism, photophobia,
Giant lysosomal granules in granulocytes,
monocytes, and lymphocytes
Chediak-Higashi Syndrome
74
Rare group of genetic disease characterized by low neutrophil count, increase risk of infection, organ dysfunction, and a high rate of leukemic transformation
Congenital Defects of Phagocytes
75
Most serious disorder related to a defect in
microbicidal activity
Chronic Granulomatous Disease (CGD)
76
Associated with a failure in Oxygen burst
mechanism of phagocytosis of neutrophils
Chronic Granulomatous Disease (CGD)
77
inability of neutrophils and monocytes to adhere to endothelial cells and to transmigrate from the blood to the tissues
Defects of motility
Leukocyte Adhesion Deficiency (LAD) Diseases
78
Myeloperoxidase (MPO) deficiency
Alius-Grignaschi anomaly
79
Granulocytes do not respond to chemotactic factors; therefore they fail to accumulate at the inflamed tissue
Lazy Leukocyte Syndrome
80
An uncommon condition where phagocytes with normal random movement but the directional motility of these cells are impaired.
Job’s Syndrome
81
most common of the lysosomal lipid storage diseases
Gaucher’s Disease
82
Gaucher’s Disease deficiency
β- glucocerebroside
83
Niemann-Pick disease
Sphingomyelinase
84
Tay-Sachs disease
Hexosaminidase A
85
Histiocytosis X in > young children,
acute, disseminated
Letterer-siwe disease
86
Histocytosis X in older persons, chronic, progressive
Hand-Schuller-Christian disease
87
Monocyte that resembles an LE cell but contains a mass with clumped chromatin.
tart cell
88
onion skin- like, chicken scratched, crinkled tissue paper)
Gaucher’s cells
