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HEMA > WBC > Flashcards

WBC Flashcards

1
Q

M0

A

Undifferentiated AML

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2
Q

M1

A

AML without maturation

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3
Q

M2

A

AML with maturation <–AML with t(8;21) <WHO></WHO>

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4
Q

M3

A

Acute PromyelocyticLeukemia,

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5
Q

M3m

A

Microgranular, PromyelocyticLeukemia

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6
Q

M4

A

Acute Myelomonocytic Leukemia

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7
Q

M5

A

Acute MonocyticLeukemia

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8
Q

M6

A

Erythroleukemia(DiGuglielmo’s)

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9
Q

M7

A

MegakaryoblasticLeukemia

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10
Q

M4Eo

A

Acute myelomonocyticleukemia with eosinophilia

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11
Q

M5a

A

Acute monoblasticleukemia, poorly differentiated

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12
Q

M5b

A

Acute monoblasticleukemia, with differentiation

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13
Q

Neutrophil

A

pink to tan with violet or lilac
granules

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14
Q

Eosinophil

A

bright orange refractile granules

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15
Q

Charcoat-Leyden crystals

A

Found hexagonal bipyramidal crystals are composed of lysophospholipase localized in the cytoplasm of eosinophils

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16
Q

Charcoat-Leyden crystals

A

Formed when there is an intense or prolonged eosinophilic inflammatory reaction

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17
Q

Thorn Test:

A

a test to measure adrenocortical function

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18
Q

Basophil

A

NUCLEUS:Clover-leaf like
CYTOPLASM: purple-black granules that
covers the nucleus

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19
Q

Monocytes

A

round, oval, kidney shaped horseshoe-shaped, indented or folded with a lacelike or stingy chromatin pattern
 CYTOPLASM: blue-gray, with fine azure granules

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20
Q

Lymphocytes

A

scant basophilic cytoplasm (light sky blue)
 Robin’s blue egg cytoplasm

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21
Q

Downey Cells

A

Any of the several atypical lymphocytes seen in infectious mononucleosis

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22
Q

Downey Cells

A

Ballerina Skirt Appearance; flared pattern cytoplasm with ends called scalloping which scallops nearby red blood cells

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23
Q

AML

A

most common type of leukemia in children younger than 18 months of age

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24
Q

Chloroma

A

Iocalized tumor masses consisting of myeloblasts; Produces a green appearance if the tissue is cut

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25
Q

Auer rods

A

Also called “faggot cells” which means “bunch of sticks”

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26
Q

AML

A

Thrombocytopenia
 Anemia (normocytic normochromic)

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27
Q

Acute Promyelocytic Leukemia

A

most aggressive of acute leukemia

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28
Q

AML with t(15;17) in WHO classification

A

Acute Promyelocytic Leukemia (FAB M3)

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29
Q

Disseminated intravascular coagulation (DIC) is most often associated

A

Acute Promyelocytic Leukemia (FAB M3)

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30
Q

referred to as Naegelitype monocyticleukemia

A

Acute Myelomonocytic Leukemia (FAB M4)

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31
Q

AML with inv(16) in WHO classification  at risk of leukostasis development

A

Acute Myelomonocytic Leukemia (FAB M4)

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32
Q

a pathological finding of slightly dilated, thin- walled vessels filled with leukemic cells.

A

Leukostasis

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33
Q

proliferation of both immature granulocytic
and erythrocytic cell types

A

Erythemicmyelosisor Di Guglielmo syndrome

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34
Q

most common cancer in children (L1)

A

Acute Lymphoblastic Leukemia

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35
Q

Terminal deoxynucleotidy ltransferase(TdT)
positive
 common ALL antigen (cALLA) is found on the
surface of lymphoblasts in 70% of patients

A

Acute Lymphoblastic Leukemia

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36
Q

FAB CLASSIFICATION OF ALL: Small homogeneous blasts; mostly in children

37
Q

FAB CLASSIFICATION OF ALL
Large heterogeneous blasts; mostly in adults

38
Q

“Burkitttype ” large basophilic B-cell blasts with vacuoles, t(8;14) alteration is common. Frequently a “starry-sky” pattern of admixed histiocytes

39
Q

most common form of leukemia in adults

40
Q

strong acid phosphatase reaction that is not
inhibited by tartaric acid or tartrate-resistant acid phosphatase (TRAP) stain

A

Hairy Cell Leukemia

41
Q

marked degree of rouleaux formation

A

Multiple Myeloma

42
Q

Produce multiple tumors, which appear on a radiograph as multiple punched-out osteoporotic lesions

A

Multiple Myeloma

43
Q

a malignancy of the lymphoplasmacytoidcells, which manufacture IgM.

A

Waldenstrom Macroglobulinemia

44
Q

characterized by the presence of Reed- Sternberg cells

A

Hodgkin type

45
Q

a large multinucleated cell resembling an “owl’s eye seen in Hodgkin lymphoma

46
Q

leukemic phase of cutaneous T-cell lymphoma, mycosis fungoides

A

Sezary Syndrome

47
Q

Rare atypical mononuclear cells with
cerebriform nuclei

A

Sezarycells

48
Q

TRAP +; pancytopenia

49
Q

an MPN that originates in an abnormal pluripotent bone marrow stem cell and is consistently associated with the BCR-ABL 1 fusion gene located in the Philadelphia chromosome

50
Q

reciprocal translocation of DNA between chromosomes 9 and 22 (t9q:22q)

A

Philadelphia chromosome

51
Q

an absolute increase in red cell mass, leukocytosis, and thrombocytosis.

A

Polycythemia Vera

52
Q

characterized by mutation of Janus 2 kinase,
JAK2 V617F

A

Polycythemia Vera

53
Q

a clonal myeloproliferative disorder primarily affecting the megakaryocytic lineage with the principal manifestation of sustained thrombocytosis

A

Essential Thrombocythemia

54
Q

disorders in which apoptosis predominates, hematopoiesis is ineffective, and cytopenias occur

A

Myelodysplastic syndromes

55
Q

giant hypogranular platelets; pseudo-Pelger-Huët

A

Myelodysplastic Syndromes

56
Q

Mature ones with a kidney-shaped or lobulated nucleus and vacuolated, basophilic, foamy cytoplasm

A

type I downey

57
Q

Plasmacytoid nuclei with less vacuolated and basophilic cytoplasm

A

type ii downey

58
Q

Binucleated lymphocytes indicates

A

lymphocytic leukemia or
leukosarcoma

59
Q

Nucleus is notched, lobulated, and cloverleaf- like; indicates CLL (Chronic Lympogenous Leukemia)

A

Reider Cells

60
Q

Seen in Niemann-Pick disease, Tay-Sachs disease, Hurley syndrome, and Burkitt lymphoma

A

Vacuolated Lymphocytes

61
Q

smudge cells are usually seen in

62
Q

basket cells

A

Granulocytic smudge cells

63
Q

Antigen markers for t cells

A

cd2 and cd3

64
Q

antigen markers for b cells

A

cd19 & cd20

65
Q

HSC antigen narkers

66
Q

an exaggerated response to infections and inflammation

A

Leukomoid reaction

67
Q

Immature white cells immature red cells and platelet abnormalities seen in peripheral smear

A

Leukoerythroblastic picture

68
Q

characterized by pale blue inclusions resembling Döhle bodies in neutrophils

A

May-Hegglin Anomaly

69
Q

Purple red; seen in patients with Hurler, Hunter,and Maroteaux-Lamy types of genetic
mucopolysaccharidosis; Gargoylism

A

Alder-Reilly Anomaly

70
Q

spectacle-like (“pince-nez”) morphology

A

Pelger-Huet Anomaly

71
Q

Found in cases of granulocytic leukemia, myedysplastic and some myeloproliferative disorders, and some infections, and after exposure to certain drugs

A

Pseudo or Acquired Pelger-Huet anomaly

72
Q

A type of WBC morphologic alterations showing a neutrophil nucleus with axial symmetry (mirror image) and is acquired in malignancies and chemotherapy

73
Q

Partial oculocutaneous albinism, photophobia,
 Giant lysosomal granules in granulocytes,
monocytes, and lymphocytes

A

Chediak-Higashi Syndrome

74
Q

Rare group of genetic disease characterized by low neutrophil count, increase risk of infection, organ dysfunction, and a high rate of leukemic transformation

A

Congenital Defects of Phagocytes

75
Q

Most serious disorder related to a defect in
microbicidal activity

A

Chronic Granulomatous Disease (CGD)

76
Q

Associated with a failure in Oxygen burst
mechanism of phagocytosis of neutrophils

A

Chronic Granulomatous Disease (CGD)

77
Q

inability of neutrophils and monocytes to adhere to endothelial cells and to transmigrate from the blood to the tissues
 Defects of motility

A

Leukocyte Adhesion Deficiency (LAD) Diseases

78
Q

Myeloperoxidase (MPO) deficiency

A

Alius-Grignaschi anomaly

79
Q

Granulocytes do not respond to chemotactic factors; therefore they fail to accumulate at the inflamed tissue

A

Lazy Leukocyte Syndrome

80
Q

An uncommon condition where phagocytes with normal random movement but the directional motility of these cells are impaired.

A

Job’s Syndrome

81
Q

most common of the lysosomal lipid storage diseases

A

Gaucher’s Disease

82
Q

Gaucher’s Disease deficiency

A

β- glucocerebroside

83
Q

Niemann-Pick disease

A

Sphingomyelinase

84
Q

Tay-Sachs disease

A

Hexosaminidase A

85
Q

Histiocytosis X in > young children,
acute, disseminated

A

Letterer-siwe disease

86
Q

Histocytosis X in older persons, chronic, progressive

A

Hand-Schuller-Christian disease

87
Q

Monocyte that resembles an LE cell but contains a mass with clumped chromatin.

88
Q

onion skin- like, chicken scratched, crinkled tissue paper)

A

Gaucher’s cells

HEMA (1 decks)

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