Water-Soluble Hormone Pathways

Question 1

cAMP Pathway

1. G protein
2. Enzyme
3. Second Messengers
4. Protein Kinase
5. Examples

Answer 1

1. Gs (Gi)
2. Adenylate cyclase
3. cAMP
4. Protein kinase A
5. Glucagon, epinephrine (B, a2), vasopressin (V2, ADH) in the kidney

Question 2

PIP2 Pathway

1. G protein
2. Enzyme
3. Second Messengers
4. Protein Kinase
5. Examples

Answer 2

1. Gq
2. Phospholipase C
3. DAG, IP3, Ca++
4. Protein kinase C
5. Vasopressin (V1, V3) in vascular smooth muscle, epinephrine (a1)

Question 3

cGMP Pathway

1. G protein
2. Enzyme
3. Second Messengers
4. Protein Kinase
5. Examples

Answer 3

1. None
2. Guanylate cyclase
3. cGMP
4. Protein kinase G
5. Atrial natriuretic peptide (ANP), Nitric oxide (NO)

Question 4

Insulin, Growth Factor Pathways

1. G protein
2. Enzyme
3. Second Messengers
4. Protein Kinase
5. Examples

Answer 4

1. Monomeric, p21 ras
4. Tyrosine kinase activity of receptor
5. Insulin, Insulin-like growth factor (IGF), Platelet-derived growth factor (PDGF), Epidermal growth factor (EGF)