Warnings/Side Effect Flashcards
Zidovidine (Retrovir)
Hematologic toxicity (neutropenia and anemia)
Myopathy
BOXED WARNING of fatty liver
Abacavir
HLA-B*5701 allele screening because of hypersensitivity reaction
increased risk in MI === AVOID in CVD
Emtricitabine
Hyperpigmentation of the palms and soles
TDF (Viread)
Renal impairment
Decrease in bone mineral density
Hyperphosphatemia
Increased risk of rising LFTs
NRTI
Warning: lactic acidosis, hepatomegaly with steatosis (fatty liver), and HBV exacerbation
Nausea, Diarrhea, HA, increased LFT
Bictegravir (Biktarvy)
Transient increase in SCr
Can take Ca and Fe if taken with food
Raltegravir (Isentress)
Increase CPK, Myopathy, Rhabdomyolysis
AVOID poluvalent cations
Elvitegravir (Genvoya, Stribild)
proteinuria
Dolutegravir (Tivicay)
HSR including heptotoxicity
Neural tubular defects in fetus
Increase in CPK
Transient increase in SCr
INSTI
Headache, insomnia, diarrhea, weight gain, rare risk of depression and suicidal ideation (except bictegravir)
SEPARATE POLYVALENT CATIONS (Ca, Mg, Fe, Al)
Efavirenz
Psych symptoms (depression, suicidal ideation)
CNS effects (AT BEDTIME DOSING)
Increased TC and TG
***take on EMPTY stomach
Rilpivirine
Depression
Transient increase in SCr
AVOID when viral load is >100,000 and CD4 count < 200
DO NOT USE WITH PPI, separate H2RA and antacids
Atazanavir (Reyataz)
Hyperbilirubinemia
Need acidic gut = separate PPI, antacid, and H2RA
Darunavir (Prezista)
Caution with sulfa allergy
Protease inhibitors “navir”
Metabolic abnormalities (insulin restistance, DLD, increase body fat)
Hepatic dysfunction
HSR
Diarrhea and nausea
DRUG INTERATIONS avoid strong CYP3A4 inducers
Ritonavir (Norvir)
Oral solution avoid with metronidazole (disulfiram rxn with alcohol)
Boosters
DRUG INTERATIONS - avoid strong CYP3A4 inducers
