wang Flashcards
etanercept
Enbrel, anti tnf alpha receptor
infliximumab
remicade, anti tnf mab chimeric
adalimumab
humaira, anti-tnf alpha mab (human)
certolizumab pegol
cimizia, pegulated anti tnf alpha mab
ustekinumab
stellara, IL-12/23 inhibitor
secukinumab
cosentyx, Il-17, contraidicated for IBD
ixekizumab
taitz, IL-17, contrindicated for IBD
broadalumab
siliq, Il-17, BBW for suicide and has a rems, contraindicated for IBD
Guselkumab
tremfya, IL-23 inhibitor
tildrakizumab
llumya, IL-23 inhibitor
risankizumab
skyrizi, IL-23 inhibitor
IL-23 inhibitor benefits
convenient infrequent dosing, and they are more safe and efficacious than a IL-12/23 inhibitor and TNF alpha inhibitor
methotrexate
- dihydrofolate reductase inhibitor
- less effective than tnf alpha inhibitors
- once a week dosing
- ADR: MYLOSUPRESSION, RENAL AND HEPATIC TOXICITY
- BBW: pregnancy category X
Acitretin
brand: Soriatane
- less effective than MTX and cyclosporine as monotherapy
- adjuct woth phototherapy
- slow can take 3-6 months
- Potent teratogen (don’t be preggo)
Ampremialst
Brand; Otezla
- PDE4 inhibitor, so increase in Camp
- oral
- Safety: GI problems in 15-20% so initial dose titration over 5 days.
Cyclosporine
- calcineurin inhibitor
- NO MYLOSUPRESSION OR HEPATOXICTY
- cannot use long term
- rapid onset and 80-90% improvement in 12-10 weeks.
roflumilast
Brand: Zoryve
- TOPICAL
- PDE-4 inhibitor
- once a day for 8 weeks
Anthralin
brand: Zithranol
- TOPICAL
- avoid application to face and skin folds
- once a day,apply thick layer and then take it off in 2 hours
- polycyclic aromatic hydrocarbon
taparinof 1% cream
brand: Vtama
- TOPICAL
- actication of the ahr receptor downregulates Il-17
once daily for 12 weeks
after cessation maintain for 4 months
tazarotene
brand: tazorac
- TOPICAL retinoid
- 0.05 and 0.1% gel and cream
- downregulates expression of inflammatory markers and inhbits proliferation of keratinocytes
- AVOID IN PREGNANCY
- ONCE A DAY
