Wake promoting drugs and the Latter

Question 1

What are Wake-promoting drugs (WPD)?

Answer 1

Narcolepsy is a rare sleep disorder (0.02- 0.06) characterised by excessive daytime sleepiness. It is possibly an autoimmune disorder caused by hypocretin deficiency

Question 2

What is caffeine?

Answer 2

Caffeine is an adenosine receptor antagonist, blocking the A1a receptor therefore reducing the inhibitory effects of adenosine.

Question 3

Dopamine synthesis

Answer 3

DA is synthesised from L-tyrosine in the cytoplasm of the neurons
DA is then converted into norepinephrine (NE) by DA β-decarboxylase

Question 4

Amphetamines

Answer 4

They block the reuptake of monoamines, especially dopamine and norepinephrine transporters
Therapeutically, they are used to treat ADHD and narcolepsy
Substance misuse and C/I: arrhythmia