Waka Flashcards
We already know heart failure is the body’s ability to not pump enough blood to meet the body’s need … what us missing from thus definition
Ir is a chronic and progressive condition
Pathophysiology. What happens in the body of a heart failure patient?
Inflammation and oxidative stress
Fluid overload
Decreased cardiac contractility
Increased vascular resistance
Neurohormonal activity
Classify heart failure based of left ventricular ejection fraction
HFrEF <40.
HFmEf 40-4[
HFpEF >=50
Classify HF based on staging.
Stage A at risk
Stage B asymptomatic Hf
Stage c symptomatic Hf
Stage D advanced Hf
Diagnosis of Hf include 4 steps mention
Symptoms
Signs
Imaging tests
Lab tests
Symptoms of Hf
Shortness of breath, fatigue swelling and chest pain
Signs
Jugular venous distension
Pedal edema
Pulmonary rales
4 Lab tests
Brain natriuretic peptide (BNP)
N-terminal pro-b-type natriuretic peptide (NT-proBNP) and
troponin
Imaging tests
Ecbocardiography
Cardiac magnetic resonance imaging
Chest xray
Lifestyle modif for HF patients
Reduce salt intake
Exercise
Watch weight
Fluid restriction
Smoking cessation
Patient education
Self monitoring of signs and symptoms
Adherence to medic
Check weight
Follow up appointments
5 Pharma therapy:for Hf
- Acei
Beta blockers
Diuretics
Aldosterone antagonists
Hydroxyzine and isosorbide dinitrate
Which of the drugs in hf doesn’t just reduce mortality and morbidity or improve symptoms and exercise tolerance.
What does that drug do?
Diuretic
Start w low dose and titrate to higher dose.
Why is this?
Function of diuretics
Increase urine productions reduce fluid overload and bp
Moa of aldosterone antagonist
Blosksththe effect of aldosterone, reducing fluid retention and bp
2 examples of aldosterone antagonist
Spironolactone and eplereno e
Moa of Hydroxyzine and isosorbide dintitrate
Hydroxyzine is a vasodilator that reduces peripheral resistance
Isosorbide dinitrate is a nitrate that reduces preload
Ivrabradine moa
A heart rate reducer that selectively inhibits the I(f) channel in the sinoartrial node
Sacubitril /Valsartan moa
Sacubitril is a neprilysin inhibitors that increases the levels of natriuretic peptides while valsartan is an angiotensin receptor blocker
Digoxin Moa
A cardiac glycoside that increases the force of contraction and slows the heart rate
Anticoagulants
Inhibits coagulation cascades and prevents formation of blood cloths
Benefit of anticoagulant?
Reduce risk of stroke systemic embolism, venous thrombo embolism