W1D3H3 - Pharmacology: Drug/Receptor Theory Flashcards
1
Q
definition of a drug
A
- any substance that acts @ the chemical (molecular level on a biological system to bring about function change
- any substance approved by the FDA for treatment/prevention of disease
2
Q
receptors
A
specific molecules that drugs interact with to cause a functional change in a biologcal system
3
Q
effectors
A
- molecules that translate the drug binding event into a biological effect
- often are enzymes
- ex: protein kinase, adenylyl cyclase, phosphodiesterase, phospholipase
4
Q
agonist
A
binds to a receptor and produces an effect
5
Q
antagonist
A
binds to a receptor and blocks the effect of an agonist
6
Q
full agonist
A
able to produce the maximal effect
7
Q
partial agonist
A
- can’t produce maximal effect even when all receptors are bound
- always has a lower efficacy than full agonist
8
Q
inverse agonist
A
reduce the low level of constitutive/basal activity observed in the absence of any agonist
9
Q
measurement of potency
A
EC50 (drug concentration needed to achieve 50% of maximal effect)
10
Q
potency
A
- indication of the amount of drug needed to produce a given effect
- dependent on the drug’s affinity, and total # of receptors
11
Q
affinity
A
measurement of the ability of the drug to bind to its receptor site
12
Q
measurement of affinity
A
Kd (drug concentration needed to bind 50% of total receptors)
