Vulvar and Ovarian Disease Flashcards
cigarette paper epithelium
or figure 8 distribution
lichen sclerosus
lichen sclerosis increases risk of?
SCC
diagnostic for lichen sclerosus?
punch biopsy
multifocal lesions, raised/flat, usu. white (or other colors) on the vulva
vulvar intraepithelial neoplasia
premalignancy of the vulva
VIN related to HPV
and who gets it
VIN, usual type
combined VIN 2&3
younger women
VIN related to lichen sclerosis
and who gets it
VIN, differentiated
older women
presence of squamous cell atypia in the vagina w/o invasion
VaIN
asymptomatic or post-coital spotting or vaginal discharge
can be isolated or multifocal lesion, red, ulcerated, or white
VaIN
VaIN 1?
lower 1/3 of epithelium
VaIN 2?
lower 2/3 of epithelium
VaIN 3
more than 2/3 of epithelium
hx of VaIN screening?
cytologic smears & HPV testing every 4-6 mo. for 1-2 years
majority of vaginal cancers?
SCC
diagnosis of vaginal cancers?
colposcopy w/ biopsy preferred
most common ovarian cyst, size, and outcome
follicular cyst
3-8 cm
can resolve spontaneously w/in 1-2 mo.
corpus luteum cyst size, relationship to cycle, and outcome
3-11 cm
related to postovulatory phase of menses
regresses after 1-2 mo.
theca lutein cyst characteristics (3)
seen with elevated hCG levels
usu. bilateral
filled w/ straw colored fluid
most common ovarian cancer & characteristics (2)
epithelial serous
usu bilateral
>15 cm in diameter
aggressive epithelial ovarian cancer
clear cell
germ cell tumor prevalence, prognosis, & markers
most common
most common germ cell tumor & presentation
dysgerminomas
mostly unilateral
2nd most common germ cell tumor & characteristics (2)
immature teratoma
unilateral
produces a-FP
what ovarian tumor secretes estrogen
granulosa cell
diagnostics for ovarian cancer (4)
pelvis u/s
Ca 125
hCG
AFP
3 unexpected assoc. w/ PCOS
acanthosis nigricans
metabolic syndrome
insulin resistance
diagnostic criteria for PCOS (4)
2 out of 4:
ovulation disorders
chemical/biochem signs of hyperandrogenism
polycystic ovaries on US
PCOS US findings (3)
> 12 follicles
2-9 mm diameter
string of pearls appearance
white atrophic papules –> smooth white plaques on vulvar epithelium
lichen sclerosus