VPATH 3205 - SYSTEMIC PATHOLOGY (1st Term Coverage - Haemic to Respiratory System) Flashcards
What are the two types of RBC disorders?
Abnormalities in shape and abnormalities in mass
True or False
Horse RBCs are larger than dog’s
False
Which species have the smallest RBC size among mammals?
Goats
Which species have a central oval nucleus and an oval shaped RBCs?
Avian
Enumerate the three abnormalities in shape of RBCs
- Poikilocytosis
- Spherocytosis
- Elliptocytosis
This alteration indicates variable shaped rbc in circulation and represents an admixture of abnormally shaped rbc in varying occurrences.
A. Elliptocytosis
B. Spherocytosis
C. Poikilocytosis
C. Poikilocytosis
These are cells with spicules
Acanthocytes
Teardrop shaped rbc
Dacryocytes
Sickle cells
Drepanocytes
thin cells
Leptocytes
fragmented RBCs
Schizocytes
Target cells
Codocytes
This change in shape of RBCs is associated with liver disease and disorders of lipid metabolism such as in diabetes.
Acanthocytes
This red cell shape is associated with fibrotic states of the marrow, in hemolytic anemia, and in reaction to certain drugs such as phenothiazine and chloramphenicol.
Dacryocytes
The origin of this red cell shape is thought to be in the pitting function involved in removing red cell inclusions.
Dacryocytes
This red cell shape develops from excess membrane and in cases where there is decreased hemoglobin that results in a relative membrane increase.
Codocytes
This red cell shape is associated with hemoglobinopathies, iron deficiency anemia, obstructive liver disease, and liver cirrhosis.
Codocytes
This red cell shape changes result from membrane damage and the usual mechanism involved is trapping of RBCs in the circulation by fibrin seen in various vascular diseases such as thrombosis and produces this cell in circulation.
Schizocytes
Their appearance in blood smears is common in vascular diseases, and in and in disseminated intravascular coagulation.
Schizocytes
Schizocytes are common in which species?
Normal young ruminants
Burr or Crenated cells
Echinocytes
This red cell shape change can be induced by a number of chemical agents, in cases of uremia, and in neoplastic diseases such as in carcinomas.
Echinocytes
This red cell shape change is thought to be based on the decrease of cell ATP, increase in calcium, and the membrane content of lysophosphatides.
Echinocytes
This red cell change is associated with certain blood parasites such as malaria and in trypanosomiasis.
Drepanocytes
In deer, this red cell shape is the normal shape of their RBCs.
Drepanocytes (Sickle cell)
This red cell shape indicates the presence of red cells with increased central thickness and is recognized in blood smears by the high staining of centers of cells.
Spherocytosis
True of False
Spherocytosis are not truly spherical
True
This red cell shape change denotes the circulation of invariably shaped red cells from spherical to almost rod-like.
Elliptocytosis
This refers to an increase of red cell mass
Polycythemia / Erythrocytosis
Other name for Erythrocytosis
Polycythemia
This term is descriptive and is employed to indicate an increase in the packed cell volume and hemoglobin concentration.
Polycythemia / Erythrocytosis
True or False
An elevated packed cell volume following a decrease in
plasma volume such as may occur in dehydration is considered as polycythemia
False
True or False
A true polycythemia occur in a disease called high altitude disease, where there occur an increase in red cell mass in cattle reared in the highlands and suddenly brought into the lowlands.
True
This is a decrease in red cell mass or hemoglobin concentration
Anemia
Anemia is a primary disease
False.
Anemia, with few exception, is not a primary disease, rather develops secondary to another disorder. Anemia is a sign or a manifestation of a disease and does not constitute a specific disease diagnosis.