Vomiting and Nausea Drugs

Question 1

Hyoscine (scoplamine)?

Answer 1

M1 antagonist, action in vestibular system, Crosses BBB, acts on the vomiting centre. Anti muscarinic side effects; dry mouth blurred vision

Question 2

Cinnarizine, Cyclizine, Promethazine

Answer 2

H1 antagonist, useful in motion sickness, acts on the vomiting cente
Promethazine sometimes used in pregnant women

Question 3

Ondansteron, granisteron

Answer 3

(Sertonin) 5HT3 antagonist, action in CTZ and GI tract,

useful in post operative vomiting

Question 4

Metoclopramide, Prochlorperazine

Answer 4

D2 antagonist, action in CTZ and GI tract,

Question 5

Nabilone

Answer 5

Cannabinoid receptor antagonist, treatment for chemotheraphy induced nausea and vomiting, can cause drawsiness and dizzines

Question 6

Aprepitant

Answer 6

targets CTZ, EMETIC CENTRE AND GI,

used in chemotherapy induced nausea and vomiting

Question 7

Dexamethasone (corticosteriods)

Answer 7

treatment for chemotherapy induced nausea and vomiting, reduce inflammation

Question 8

Non pharmacological approaches to treating nausea and vomiting?

Answer 8

P6 acupoint stimulation
massage bands,
HERBAL REMEDIES such as lemon oil, ginger, mint

Question 9

What’s meinere disease?

Answer 9

Disorder of the inner ear, resulting in nausea, hearing loss, tinnitus.
Treated with H1 antagonists (Cinnarizine, CYCLIZINE, promethazine)
Bethahistidine (H3 antagonist but H1 agonists)
H3 antagonists increase neurotransmitter release and blood flow so reduced pressure