Volatiles: Numbers to Know Flashcards

1
Q

Blood:Gas PC of Desflurane

A

0.42 : 1

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2
Q

Blood:Gas PC of Nitrous

A

0.46 : 1

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3
Q

Blood:Gas PC of Sevoflurane

A

0.69 : 1

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4
Q

Blood:Gas PC of Isoflurane

A

1.46 : 1

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5
Q

Blood:Gas PC of Enflurane

A

1.9 : 1

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6
Q

Blood:Gas PC of Halothane

A

2.54 : 1

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7
Q

Minutes to recovery after 2 hours 1.6 MAC of Halothane

A

60

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8
Q

Minutes to recovery after 2 hours 1.6 MAC of Isoflurane

A

30

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9
Q

Minutes to recovery after 2 hours 1.6 MAC of Sevoflurane

A

12

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10
Q

Minutes to recovery after 2 hours 1.6 MAC of Desflurane

A

8

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11
Q

1 MAC =

A

ED50 @ 1 atm

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12
Q

1.3 MAC =

A

ED95-99 @ 1 atm

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13
Q

MAC awake =

A

0.3-0.5

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14
Q

MAC bar =

A

1.7-2.0

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15
Q

MAC values are based on

A

age 35-55
37 degrees C
760 mmHg
1 atm (sea level)

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16
Q

MAC % of Nitrous

A

104

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17
Q

MAC % of Desflurane

A

6.6

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18
Q

MAC % of Sevoflurane

A

1.8

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19
Q

MAC % of Enflurane

A

1.63

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20
Q

MAC % of Isoflurane

A

1.17

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21
Q

MAC % of Halothane

A

0.75

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22
Q

Vapor pressure of Desflurane

A

669 torr

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23
Q

Vapor pressure of Halothane

24
Q

Vapor pressure of Isoflurane

25
Q

Vapor pressure of Enflurane

26
Q

Vapor pressure of Sevoflurane

27
Q

Without bronchospasm, baseline pulmonary resistance unchanged by

28
Q

Ischemic preconditioning can occur as low as

A

0.25 MAC (still moving)

29
Q

Decreased CNS activity begins at

A

0.4 MAC (wakefulness changes to unconsciousness)

30
Q

Burst suppression occurs at

31
Q

Electrical silence occurs at

32
Q

Enflurane causes seizures especially at

A

2 MAC or PaCO2 < 30 mmHg

33
Q

Decreased amplitude & increased latency of SSEPs & MEPs can occur at

A

0.5-1.5 MAC

34
Q

Gas mixture ideal for SSEP & MEP monitoring

A

Nitrous 60% + 0.5 MAC = 1 MAC

35
Q

Volatiles start to increase CBF at

A

0.6 MAC (within minutes despite lack of BP change)

36
Q

Loss of auto-regulation in everyone occurs at

37
Q

Loss of auto-regulation w/ Halothane

38
Q

Loss of auto-regulation w/ Sevo

39
Q

Loss of auto-regulation w/ Iso & Des

A

0.5-1.5 MAC

40
Q

Volatiles start to increase ICP at ______; can increase ICP by _______

A

0.8 MAC; 7 mmHg

41
Q

Apnea occurs at

A

1.5-2.0 MAC

42
Q

Blunt hypoxic response occurs at ______ w/ _____% depression

A

0.1 MAC; 50-70%
1.1 MAC; 100%

43
Q

HPV occurs w/in _______ when regional blood flow is ______

A

5 minutes; half

44
Q

HPV maximal response lasts

45
Q

% depression of HPV at 2 MAC

46
Q

Sevo increases HR after

47
Q

Iso & Des increase HR at

A

lower concentrations

48
Q

Volatiles increase portal vein flow at

49
Q

Type 1 hepatotoxicity happens in ___% of patient _______ after exposure

A

20; 1-2 weeks

50
Q

Type 2 hepatotoxicity lasts for ______ after exposure

51
Q

Mortality of MH if untreated

52
Q

PONV occurs in _______% of patients

53
Q

PONV occurs with Nitrous at

A

> 0.5 MAC (50% of patients)

54
Q

Obstetric effects occur at

55
Q

Nitrous can’t deliver even