Volatiles: Numbers to Know Flashcards
Blood:Gas PC of Desflurane
0.42 : 1
Blood:Gas PC of Nitrous
0.46 : 1
Blood:Gas PC of Sevoflurane
0.69 : 1
Blood:Gas PC of Isoflurane
1.46 : 1
Blood:Gas PC of Enflurane
1.9 : 1
Blood:Gas PC of Halothane
2.54 : 1
Minutes to recovery after 2 hours 1.6 MAC of Halothane
60
Minutes to recovery after 2 hours 1.6 MAC of Isoflurane
30
Minutes to recovery after 2 hours 1.6 MAC of Sevoflurane
12
Minutes to recovery after 2 hours 1.6 MAC of Desflurane
8
1 MAC =
ED50 @ 1 atm
1.3 MAC =
ED95-99 @ 1 atm
MAC awake =
0.3-0.5
MAC bar =
1.7-2.0
MAC values are based on
age 35-55
37 degrees C
760 mmHg
1 atm (sea level)
MAC % of Nitrous
104
MAC % of Desflurane
6.6
MAC % of Sevoflurane
1.8
MAC % of Enflurane
1.63
MAC % of Isoflurane
1.17
MAC % of Halothane
0.75
Vapor pressure of Desflurane
669 torr
Vapor pressure of Halothane
243 torr
Vapor pressure of Isoflurane
238 torr
Vapor pressure of Enflurane
175 torr
Vapor pressure of Sevoflurane
157 torr
Without bronchospasm, baseline pulmonary resistance unchanged by
1-2 MAC
Ischemic preconditioning can occur as low as
0.25 MAC (still moving)
Decreased CNS activity begins at
0.4 MAC (wakefulness changes to unconsciousness)
Burst suppression occurs at
1.5 MAC
Electrical silence occurs at
2 MAC
Enflurane causes seizures especially at
2 MAC or PaCO2 < 30 mmHg
Decreased amplitude & increased latency of SSEPs & MEPs can occur at
0.5-1.5 MAC
Gas mixture ideal for SSEP & MEP monitoring
Nitrous 60% + 0.5 MAC = 1 MAC
Volatiles start to increase CBF at
0.6 MAC (within minutes despite lack of BP change)
Loss of auto-regulation in everyone occurs at
1 MAC
Loss of auto-regulation w/ Halothane
0.5 MAC
Loss of auto-regulation w/ Sevo
1 MAC
Loss of auto-regulation w/ Iso & Des
0.5-1.5 MAC
Volatiles start to increase ICP at ______; can increase ICP by _______
0.8 MAC; 7 mmHg
Apnea occurs at
1.5-2.0 MAC
Blunt hypoxic response occurs at ______ w/ _____% depression
0.1 MAC; 50-70%
1.1 MAC; 100%
HPV occurs w/in _______ when regional blood flow is ______
5 minutes; half
HPV maximal response lasts
2-4 hours
% depression of HPV at 2 MAC
50
Sevo increases HR after
> 1.5 MAC
Iso & Des increase HR at
lower concentrations
Volatiles increase portal vein flow at
1-1.5 MAC
Type 1 hepatotoxicity happens in ___% of patient _______ after exposure
20; 1-2 weeks
Type 2 hepatotoxicity lasts for ______ after exposure
1 month
Mortality of MH if untreated
80%
PONV occurs in _______% of patients
25-30
PONV occurs with Nitrous at
> 0.5 MAC (50% of patients)
Obstetric effects occur at
0.5-1 MAC
Nitrous can’t deliver even
1 MAC