Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Volatiles > Flashcards

Volatiles Flashcards

1
Q

What is the MAC of sevoflurane

A

2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the MAC of Desflurane

A

6.5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the MAC of Isoflurane

A

1.17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MAC of Enflurane

A

1.63

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the MAC of Halothane

A

0.75

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the blood:gas coefficient of Sevoflurane

A

0.69

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the blood:gas coefficient of Desflurane

A

0.42

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the blood:gas coefficient of Isoflurane

A

1.4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the blood:gas coefficient of Enflurane

A

1.90

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the blood:gas coefficient of Halothane

A

2.54

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the metabolites of Sevoflurane, and how much is metabolized?

A

Inorganic and organic fluorides
Compound A in the presence of soda lime and heat
Also compounds (B-E)
3.5% metabolised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is compound A

A

A toxic compound produced by interaction of Sevoflurane with CO2 absorbers
Causes renal tubular necrosis in rodent models in concentrations >300ppm after 3hrs exposure. Human threshold is ~150ppm
Unlikely to be clinically relevant as ~20ppm measured at low flow rates after 5hrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the metabolites of Halothane

A

Trifluoroacetic acid
Cl-, Br-
20% metabolised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the metabolites of Enflurane

A

Inorganic and organic fluorides

2% metabolised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the metabolites of Isoflurane

A

Trifluoroacetic acid and F-

0.2% metabolised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the metabolites of Desflurane

A

Trifluoroacetic acid

0.02% metabolised

17
Q

Outline the cause of Halothane hepatitis

A

Immune mediated hepatits
Antibodies are formed against liver microsomal proteins on the surface of hepatocytes that have been covalently modified to form neoantigens by the reactive oxidative trifluoroacetyl halide metabolite of halothane

18
Q

How do volatiles produce CO

A

volatile agents interact with sodalime or baralyme absorbers to form CO
Des > Enf > Iso
Production is worse if the CO2 absorber is hot and dry (eg after a machine is left idle overnight/weekends)

Pharmacology (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions