Vocabulary Test 1 Flashcards
A drug that activates a receptor by binding to it and produces that same effect the endogenous ligand would.
Agonist
A drug that binds w/o activating the receptor and blocks the agonists/endogenous ligand.
Antagonist
An antagonist concentration is increased that progressively inhibits the response to the agonist.
Competitive Antagonism
You have administered an antagonist and are trying to overcome it with an agonist but you cannot completely overcome the antagonistic effects. What is this called?
Non-competitive Antagonism
This type of drug binds to the agonist site (orthosteric site) and activates the receptor but not completely. Also, when you gave an agonist, it’s effects were not seen.
Partial Agonist
Can act as an antagonist in combination with an agonist bc it blocks its orthosteric site.
This type of drug binds to the orthosteric site/competes with an agonist but produces the opposite effect of the agonist and also turns off the receptors constitutive activity.
Inverse Agonist
A decreased response to the same drug dose.
Tolerance or Tachyphylaxis
Your body’s effect on the drug, ADME.
Pharmacokinetics
This is a hypothetical volume into which a drug initially distributes upon administration of and can be thought of as the blood in vessels and tissues which are highly perfused with blood.
Central Volume
A group of organs that make up the bulk of arterial blood flow (heart, brain, kidneys, liver)
Vessel-rich group
A type of process that happens at a set/constant rate. (Rate is constant) (i.e. consumption of O2 and production of CO2)
Zero-order process
A type of process that happens at a rate that is proportional to the amount where clearance is constant.
First-order process
The time is takes for a drug concentration to decrease by 50% via body elimination.
Dose-dependent, organ function dependent.
Half-life
The time for the plasma concentration to decrease by 50% from an infusion that maintains a constant concentration.
(This is important to consider in ICU/long cases with long infusions and hangovers.)
It requires a longer amount of time to metabolize the drug because only half % of the drug is eliminated at specific time intervals.
Context-sensitive Half-Time
NOT dose-dependent; Based on the drugs Vd (volume of distribution)/ receptors uptake of medication out of the plasma
NOT based on organ function but on chemical properties
Time for plasma concentration to fall 50%
Half-time
Your body’s ability to eliminate a drug based off its concentration and time.
Clearance
The quantitative study of your body’s response to a drug.
(what a drug does to the body)
Pharmacodynamics