Vocab Flashcards
ED 50
Dose required to produce a therapeutic effect in 50% of the population
Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
TD 50
Dose required to produce a toxic effect in 50% of the pop
Therapeutic index
LD (or TD) 50/ ED50
The larger the better
Kd
Equilibrium dissociation constant
Koff/ k on
Smaller kd= larger the binding affinity
Partial agonist
Drug that binds to a receptor and illicit a response, but the response is only of partial efficacy relative to a full agonist
Non-competitive antagonists
Covalently bond to the receptor- reduce the number of receptors
Loading dose
Loading dose = (apparent volume)(c max)
Maintenance dose
= (apparent volume)(Cmax - Cmin)
What effects the duration of action?
Min effective concentration
Max non toxic concentration
Half life
Maintenance dose interval=
= 2.303/ k x log (Cmax/Cmin)
Bioavailability
Fraction absorbed into systematic circulation
Atrial Fibrillation
the most common abnormal heart rhythm
Histogram
graphical representation of the distribution of data
hypoperfusion
circulatory shock, low BP, high heart rate- inadequate aerobic cellular respiration
Heme
a chemical prosthetic group consisting of an Fe 2+ ion contained in the center of an large organic ring called a porphyrin
Biliruben
Yellow breakdown of normal heme catabolsim, Bilirben is excreted in bile and urine, its color is responsible for the yellow color of bruises and the yellow color of urine and the brown color of feces.
AST
Aspartate Transaminase, an enzyme involved in amino acid metabolism, found in the liver, and is used as a marker for liver health. Normal Blood levels should be less than 50
ALT
Alanine Aminotransferase, enzyme found in the liver, blood levels above 50 indicate liver damage
myalgias
muscle aches
Jaundice
a yellow coloring of the skin, mucus or eyes. The yellow coloring comes from biliruben.
Exogenous
Materials come outside of the body
Endogenous
Things created by the body
Drug (official def)
a substance intended for the use in the diagnosis, cure, mitigation, treatment or prevention of a disease. A substance (other than food) intended to effect the structure or function of the body
