Vitiligo

Question 1

Vitiligo
Worldwide percentage occurence.
Sex
it occurs in any age but 50% occurs in what age

Answer 1

1%
Equal
10-30 yo

Question 2

3 principal theories in Vitiligo

Answer 2

Autoimmune theory
Self destruct theory
neurogenic hypothesis

Question 3

Phenolic compound most common cause of vitiligo.

Answer 3

4 tertiary butyl phenol

Question 4

What does a pigmentarion around a follicle in a white macule mean?

Answer 4

residual pigmentation or repigmentation

Question 5

“lip tip pattern” inclusion

Answer 5

skin around the mouth as well as on distal ngers and toes; lips, nipples, genitalia, and anus may be involved

Question 6

type of vitiligo in 1 unilateral region.

Answer 6

Segmental vitiligo

Question 7

Circumscribed areas o white hair, analogous to vitiligo macules, are called.

Answer 7

Poliosis

Question 8

Vogt–Koyanagi–Harada syndrome Consists of what symptoms.

Answer 8

vitiligo + poliosis + uveitis + dysacusis + alopecia areata.

Question 9

What can be seen on ELEctron microscopy?

Answer 9

Absence of melanocytes and of melanosomes in keratinocytes

Question 10

Repigmentation tx for localized macules.

Answer 10

topical steroid, calcineurin inh.
Topical photochemotx
Excimer laser (308nm)- best result in face.

Question 11

General vitiligo tx.

Answer 11

systemic photochemotx.

Question 12

Used for depigmentation of skin.

Answer 12

monobenzyl ether of hydroquinone 20% cream- irreversible and permanent.
Success rate >90%