Vitamins and Minerals Flashcards

1
Q

What is Vitamin B1?

A

Thiamin

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2
Q

What is Thiamin’s (B1) role in metabolism?

A

Coenzyme Thiamin phosphate
Used for oxidative decarboxylation of Pyruvate to Acetyl-CoA -> Lactate
Also used in TCA Cycle and Pentose-Phosphate Pathway
Thiamin TRIphosphate -> activates CL channels in Nerve cells

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3
Q

What signs will you see with Vitamin B1 deficiency?

A

Decreased appetite, emaciation, muscle weakness and nervous system dysfunction
Induced by Thiaminase (Bracken, Raw Fish)

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4
Q

What are the two types of Vitamin B2?

A

Riboflavin and Nictotinamide

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5
Q

What are the 3 types of Vitamin B6?

A

pyridoxine, pyridoxal, pyridoxamine

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6
Q

What is Vitamin B12 known as?

A

Cyanocobalamin

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7
Q

What are the metabolic functions of Vit B2 Riboflavin?

A

Flavoproteins and transport of H in reactions (in TCA cycle and Co-enzyme fo Acyl-CoA dehydrogenase)

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8
Q

What are the sings of B2 Riboflavin deficiency?

A

Calves -> loose appetite, D+ and Mouth lesions
Pigs -> prevents premature birth, keeps oestrus cycle normal and deficient will see reduced growth
Poultry -> curled toe paralysis and embryonic abnormalities

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9
Q

What are the matabolic functions of Vit B2 Nicotinamide?

A

-> Nicotinic acid
Stable, synthesised in body and activates enzymes: NAD (TCA Cycle) and NADP (Pentose phosphate pathway)
Give to reduced bovine ketosis, pigs see slow growth and anorexia, poultry see bone reduction, loss of feathers and mouth inflammation

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10
Q

What are the metabolic functions of B6 Pyridoxine?

A

in 3 interchangable forms
functions as pyridoxal phosphate
used for transaminations and decarboxylation -> AA as energy source and aa absorption
Deficiency unlikely

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11
Q

Metabolic function of B5 Pantothenic acid?

A

Constitue of Co-Enzyme A (CoA), used inm energy motabolism

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12
Q

Vitamin B7 biotin metabolic functions

A

Found in important enzymes: pyruvate carboxylase catalase -> gluconeogenesis, A-Coa Carboxylase (TAG) and Propinoyl COa Carboxylase (TCA cycle)

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13
Q

What happens in B7 Biotin deficiency?

A

Pigs -> foot lesions, hair loss, reduced growth and fertility
Poultry = reduced growth, skin poor, leg bone abnormalities and reduced feathers and fatty liver
Ruminants -> will make enough, important in hoof quality

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14
Q

Metabolic functions of B9 folic acid

A

-> made into tetrahydrofolic acid
Used in co-enzyme for single carbon group utilisation,
DNA, RNA and NT synthesis
Leafy greens are good source -> UV degrades it

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15
Q

What would you see if deficient in B9 Folic acid?

A

Chickens/Poultry: decreased growth, anaemia, bone issues and egg production
Supplement folic acid at times of growth

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16
Q

Metabolic function of Choline

A

Found in lecithin -> promotes lipid metabolism, perverts accumulation of fats
Found in Ach (hence the name..)
Choline -> synthesised in liver from methionine

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17
Q

Deficiency of Choline

A

Due to lack of synthesis so linked to methionine in diet -> reduced growth and fatty liver

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18
Q

Vitamine B12 Cyanocobalamin metabolic functions

A

Microbial in origin -> specific glycoprotein needed to bind to intestine
Metabolic roles: isomerases, dehydrases, enzyme synthesis, propionate metabolism

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19
Q

Vitamind B12 cyanocobalamin deficiency

A

Young animals most likely causing reduced growht, and in pigs high mortaility

20
Q

Describe the relationship between Vitamin b12 Cyanocobalamin and Cobalt

A

Ruminants (bacteria) require cobalt to synthesise B12 which without it can cause reduced growth, reduced ability to eat, anaemia and emaciation

21
Q

What are the metabolic functions of Magnesium? (Mg)

A

Common enzyme activator, used in formation of cAMP, used in cell respiration and muscle activity.

22
Q

Why can excess potassium in the rumen cause problems for ruminants?

A

Ruminant main Mg absorption is in rumen, too much K will interact with Na channels and Mg -> meaning Mg is no absorbed and there is insufficient Mg absorption in S.I and L.I
Leads to HYPOMAGNESIUM TETANY (CR Week 11)

23
Q

What are the metabolic functions of Selenium?

A
  • Incorporated into antioxidant enzyme Glutathione peroxidase (reduces hydroperoxides)
  • Immune response
  • Iodine metabolism
    Metabolism of fatty acids and glucose
24
Q

What are the symptoms of Selenium deficiency?

A
White muscle disease
Ill thrift
Reduced growth
Decreased wool production
Impared immune function
Decreased reproductive performance
Pigs -> Mulberry heart, hepatosis dietic
Poultry - encephalomacia and exudative diathesis, pancreatic fibrosis
25
Q

Describe the interaction between Selenium and Vitamin E

A

Vit E is membrane bound
Selenium aids in the retention of VitE in plasma, reduced VitE required for membrane integrity
Vit E maintains Se in body in active form (GSHPx) -> lowers requirement for it

26
Q

What is a good source of Vitamin E?

A

Young grass

Must have a good source as not stored in the body.

27
Q

What are you likely to see in a vitamin E deficiency in pigs, poultry and horses?

A

All 3 will see muscular myopathy
Pigs -> mulberry heart (increased VitE increases litter size)
Poultry -> pectoral myopathy, encephalomacia and exudative diathesis
Horses -> lameness, muscle rigidty, myoglobin release in urine (brown wee)

28
Q

What will you see with Selenium Toxicity?

A

Alkali disease
Blind staggers
- dullness, rough coat, hair-loss, soreness, stiffness, lameness, sudden deaf and sore hooves
Mostly caused by Ragwort

29
Q

What are the metabolic functions of Copper?

A
  • Essential component of metalloenzymes
  • Activates enzyme system
  • Used in CNS and heart development
  • Fe metabolism
  • Immune system
  • Antioxidant
30
Q

What are you likely to see in pigs, non-ruminants and poultry with copper toxicity?

A

Pigs -> highly tolerant (used as a growth promoter)
Non-ruminants -> growth retardation
Poultry- erosion of gizzard

31
Q

What are the signs of copper deficiency in ruminants?

A

Swayback (enzootic neonatal ataxia)
Hair/wool keratinisation and pigmentation
Loss of hair around eyes, ears and muzzle
Bone disorders – oesteoporosis and impaired oesteoblastic activity
Anaemia
Infertility
Immune function
Lipid metabolism and oxidative stress
Impaired glucose metabolism

32
Q

Give an example of a Copper enzyme

A

Cytochrome c oxidase
Lysyl oxidase
Tyrosinase
Superoxidase dismutase

33
Q

What are the signs of copper toxicity in ruminants?

A

Weak, tremulous, listless, anorexic, HAEMOLYTIC CRISIS (breakdown of Hb into urine and plasma)

34
Q

Cats are carnivores. What three substances MUST they acquire from meat?

A

Taurine, arachidonic and pre-formed vitamin A

35
Q

What will taurine deficiency cause in cats?

A

Cardiomyopathy and irreversible blindness

36
Q

What vitamin has to be provided for guinea pigs due to their inability to synthesise it?

A

Vit C

37
Q

What are the metabolic functions of Iron?

A

Majority is bound to proteins such as Hb, transferring and ferritin.
Involved in TCA cycle enzymes
Cytochromes utilise oxidation and reduction of iron in the electron transport chain

38
Q

What are the signs of iron deficiency?

A

ANAEMIA -> mostly seen only in suckiling piglets hence injection at 3 days old. Causes reduced growth and thumps

39
Q

What are the metabolic functions of Manganese?

A

Major enzyme activator

Found in pyruvate carboxylase

40
Q

What signs will you see if an animal is deficient in manganese?

A

Reduced growth, ataxia, reproductive failure, decreases glucose utilisation and reduced blood clotting response

41
Q

What is the main function of iodine?

A

In the synthesis of thyroid hormones

42
Q

What are the symptoms of iodine deficiency?

A

Enlarged thyroid gland, reproductive abnormalities, reduced wool growth, goitrogens

43
Q

What is the metabolic role of Zinc?

A
  • essential in 200 enzymes
    Activate enzyme system
    used in cell replication and differentiation
    hormone production, storage and secretion
44
Q

What signs will you see in zinc deficiency?

A

Parakeratosis, reduced growth, stiff joints, swollen hock (chickens)
Normally caused by high Ca and Cu diets due to interaction with Zn

45
Q

What are the signs of lead toxicity?

A

Acute -> GI haemorrhage, anaemia, kidney damage, liver necrosis
Chronic -> osteoporosis, reduced appetite and lead line