Vitamins and Minerals Flashcards
What is Vitamin B1?
Thiamin
What is Thiamin’s (B1) role in metabolism?
Coenzyme Thiamin phosphate
Used for oxidative decarboxylation of Pyruvate to Acetyl-CoA -> Lactate
Also used in TCA Cycle and Pentose-Phosphate Pathway
Thiamin TRIphosphate -> activates CL channels in Nerve cells
What signs will you see with Vitamin B1 deficiency?
Decreased appetite, emaciation, muscle weakness and nervous system dysfunction
Induced by Thiaminase (Bracken, Raw Fish)
What are the two types of Vitamin B2?
Riboflavin and Nictotinamide
What are the 3 types of Vitamin B6?
pyridoxine, pyridoxal, pyridoxamine
What is Vitamin B12 known as?
Cyanocobalamin
What are the metabolic functions of Vit B2 Riboflavin?
Flavoproteins and transport of H in reactions (in TCA cycle and Co-enzyme fo Acyl-CoA dehydrogenase)
What are the sings of B2 Riboflavin deficiency?
Calves -> loose appetite, D+ and Mouth lesions
Pigs -> prevents premature birth, keeps oestrus cycle normal and deficient will see reduced growth
Poultry -> curled toe paralysis and embryonic abnormalities
What are the matabolic functions of Vit B2 Nicotinamide?
-> Nicotinic acid
Stable, synthesised in body and activates enzymes: NAD (TCA Cycle) and NADP (Pentose phosphate pathway)
Give to reduced bovine ketosis, pigs see slow growth and anorexia, poultry see bone reduction, loss of feathers and mouth inflammation
What are the metabolic functions of B6 Pyridoxine?
in 3 interchangable forms
functions as pyridoxal phosphate
used for transaminations and decarboxylation -> AA as energy source and aa absorption
Deficiency unlikely
Metabolic function of B5 Pantothenic acid?
Constitue of Co-Enzyme A (CoA), used inm energy motabolism
Vitamin B7 biotin metabolic functions
Found in important enzymes: pyruvate carboxylase catalase -> gluconeogenesis, A-Coa Carboxylase (TAG) and Propinoyl COa Carboxylase (TCA cycle)
What happens in B7 Biotin deficiency?
Pigs -> foot lesions, hair loss, reduced growth and fertility
Poultry = reduced growth, skin poor, leg bone abnormalities and reduced feathers and fatty liver
Ruminants -> will make enough, important in hoof quality
Metabolic functions of B9 folic acid
-> made into tetrahydrofolic acid
Used in co-enzyme for single carbon group utilisation,
DNA, RNA and NT synthesis
Leafy greens are good source -> UV degrades it
What would you see if deficient in B9 Folic acid?
Chickens/Poultry: decreased growth, anaemia, bone issues and egg production
Supplement folic acid at times of growth
Metabolic function of Choline
Found in lecithin -> promotes lipid metabolism, perverts accumulation of fats
Found in Ach (hence the name..)
Choline -> synthesised in liver from methionine
Deficiency of Choline
Due to lack of synthesis so linked to methionine in diet -> reduced growth and fatty liver
Vitamine B12 Cyanocobalamin metabolic functions
Microbial in origin -> specific glycoprotein needed to bind to intestine
Metabolic roles: isomerases, dehydrases, enzyme synthesis, propionate metabolism