Vitamin deficiency/cosubstrates

Question 1

Thiamine B1

Answer 1

Beriberi
Aka TPP
Co enzyme of PDH

Question 2

Riboflavin B2

Answer 2

Cheilosis and corneal neovascularization
FADH2
Co enzyme of PDH

Question 3

Niacin B3

Answer 3

Hartnup disease blocks absorption
Causes pellagra (4 Ds)
Co enzyme of PDH

Question 4

Pantothenic Acid B5

Answer 4

Extremely rare deficiency

Question 5

Pyridoxine B6

Answer 5

Sideroblastic anemia and cheilosis

Homocysteinemia

Question 6

Biotin B7

Answer 6

Excessive raw eggs cause deficiency

Carboxylase co enzyme

Question 7

Folate B9

Answer 7

Causes homocysteinemia
Important in pyrimidine synthesis
(Blocked by methotrexate and 5-fluorouracil)

Question 8

Cobalamin B12

Answer 8

Pernicious anemia causes deficiency

Homocysteinemia and megaloblastic anemia and enflamed tongue

Question 9

Ascorbate C

Answer 9

Scurvy

Question 10

Vitamin A

Answer 10

Night blindness from retinol defect

Question 11

Vitamin D

Answer 11

Rickets

Question 12

Vitamin K

Answer 12

Clotting factor

Deficiency causes bruising and excessive bleeding

Question 13

Vitamin E

Answer 13

Deficiency leads to Chrohn’s and peripheral neuropathy

Question 14

2-oxoglutaric aciduria

Fumarase deficiency

Answer 14

Presents with global developmental delay and Neuro issues

Urine sampling main diagnosis