Visual Pathways and Control of Eye Movements Flashcards
What are the main landmarks of the visual pathway?
Eye
Optic Nerve
Optic Chiasm
Optic Tract
Lateral Geniculate Nucleus - ganglion nerve fibres synapse here
Optic Radiation - 4th order neurons
Primary Visual Cortex (Striate Cortex)
Where do retinal ganglion axons coming down the optic nerve synapse?
Lateral Geniculate Nucleus
Where is the lateral geniculate nucleus found?
Thalamus
What are the fibres leaving the lateral geniculate nucleus called?
Optic Radiation
OPTIC RADIATION. Which order neurones are these and where do they terminate?
4th Order Neurones.
They terminate in the primary visual cortex
What are the first, second and third order neurones in the visual pathway?
First Order – photo-receptors (rods and cones)
Second Order – retinal bipolar cells
Third Order – retinal ganglion cells
What happens as the retinal ganglion cells enter the optic nerve, which improves the transmission of the signal?
They become myelinated
What percentage of retinal ganglion cell fibres crosses the midline at the optic chiasma?
53%
Describe the convergence and receptive field sizes of rods and cones.
Rods have high convergence and large receptive fields.
Cones have low convergence and small receptive fields
Describe how the convergence of the rod system differs across different parts of the retina.
The rod system near that macula has lower convergence than in the peripheral retina
What is the benefit of having high convergence and a large receptive field?
High light sensitivity
What is the benefit of having low convergence and a small receptive field?
Fine visual acuity
Retinal ganglion cells can be described as on-centre or off-centre. What do these two terms mean?
On-centre – they are stimulated by light falling on the centre of the receptive field and inhibited by light falling on the edge of the receptive field.
Off-centre – they are stimulated by light falling on the edge of the receptive field and inhibited by light falling on the centre.
This is important in contrast sensitivity and enhanced edge detection
Where do the fibres that decussate at the optic chiasma originate?
The nasal part of the retina.
These fibres are responsible for the temporal half of the visual field
What effect do lesions anterior to the optic chiasm have on vision?
Affects only ONE eye
What effect do lesions posterior to the optic chiasm have on vision?
Affects BOTH eyes.
Right-sided lesion: left homonymous hemianopia.
Left-sided lesions: right homonymous hemianopia
What is the effect of a lesion at the optic chiasm?
Bitemporal hemianopia
Which part of the brain does the upper division of the optic radiation travel through and which parts of the visual field is it responsible for?
Parietal Lobe.
Responsible for the inferior visual quadrants
Which part of the brain does the lower division of the optic radiation travel through and what part of the visual field is it responsible for?
Temporal Lobe.
Responsible for the superior visual quadrants
The lower division loops inferiorly and anteriorly before going posteriorly towards the primary visual cortex. What is this loop called?
Meyer’s Loop
What would be the consequence of a lesion in Meyer’s loop?
Superior homonymous quadrantopia.
Left or RIGHT depends on the where the lesion is
What would be the consequence of a lesion of the upper division of the optic radiation?
Inferior homonymous quadrantopia
What is homonymous hemianopia typically caused by?
Strokes and other cerebrovascular accidents
Where is the primary visual cortex located?
Along the Calcarine Fissure in the occipital lobe
Describe which parts of the primary visual cortex are responsible for the different fields of vision.
The macula has a disproportionate representation in the primary visual cortex.
The left primary visual cortex is responsible for the right visual field from both eyes.
The right primary visual cortex is responsible for the left visual field from both eyes.
Visual cortex above the calcarine fissure is responsible for the inferior visual field.
Visual cortex below the calcarine fissure is responsible for the superior visual field
How is it possible for the macula to be spared by a stroke in the primary visual cortex leading to homonymous hemianopia?
The area representing the macula in the primary visual cortex has a dual blood supply (from both right and left posterior cerebral arteries) meaning that it is less vulnerable to ischaemia
What are the two pathways of the extrastriate cortex and what are they responsible for?
Dorsal Pathway – deals with motion detection.
Ventral Pathway – handles detailed object recognition and face recognition
Describe what happens to the eyes in the light.
Iris circular muscle contracts.
Constriction of pupillary aperture.
Reduced rate of photopigment bleaching.
Increased depth of field
Describe the pathway that is responsible for the consensual lightreflex.
Draw if possible
Retinal ganglion cells from the retina send they axons back via the optic nerve.
The fibres that are responsible for the pupillary reflex will get passed the optic chiasm and then leave the posterior 1/3 of the optic tract before it reaches the LGN.
The axons then go to the pretectal nucleus in the dorsal brainstem.
The afferent pathways from each eye then synapse on the Edinger-Westphal nuclei on both sides of the brainstem.
A parasympathetic nerve from the Edinger-Westphal nuclei to the ciliary ganglion forms the efferent pathway.
Short ciliary nerves travel from the ciliary ganglion to the pupillary sphincter
Summary: Retinal Ganglion Cell –> Pretectal Nucleus –> Edinger-Westphal Nucleus –> Ciliary Ganglion –> Short Ciliary Nerves –> Sphincter Pupillae
What would the consequences be of a right afferent defect?
Light shone in right eye: no direct or consensual response.
Light shone in left eye: direct and consensual response present
What would the consequences be of a right efferent defect?
Light shone in right eye: no direct response, tHERE IS consensual response present.
Light shone in left eye: direct response, no consensual response
What does RAPD mean?
Relative Afferent Pupillary Defect.
A partial pupillary response is still present despite damage to an eye and its pupillary reflex pathway – there is some degree of constriction
What test would you do to identify RAPD? What would you expect to see in a patient showing a RAPD?
Swinging Torch Test.
When the light is shone on the good eye, there will be a direct and consensual response.
When the light is then swung and shone at the bad eye, there will be a paradoxical dilation of the iris on BOTH EYES
This is because the constriction response elicited by the bad eye is weaker than the consensual response elicited by the good eye
Define: a. Duction b. Version c. Vergeance d. Convergeance
a. Duction Movement of one eye
b. Version -Simultaneous movement of both eyes
c. Vergeance- Simultaneous movement of both eyes in opposite directions
d. Convergeance- Simultaneous adduction of both eyes when viewing a near object
What is the term for the elevation of one eye?
Supraduction
What is the term for the depression of both eyes?
Infraversion
What is the technical term for right gaze?
Dextroversion
What is the technical term for left gaze?
Levoversion
What are the two types of eye movement and how are they different? Describe them exhaustively
Saccade – short fast burst. Up to 900 degrees/s. Types are:
- Reflexive saccade to external stimuli
- Scanning saccade
- Predictive saccade to track objects
- Memory-guided saccade
Smooth Pursuit – sustained slow movement of around 60 degrees/s. it is driven by motion of a moving target across the retina.
What reflex is used to assess visual acuity in preverbal children?
Optokinetic Nystagmus Reflex- It is a form of physiological nystagmus triggered by the presentation of a constantly moving grating pattern
State which nerve innervates each of the extrinsic eye muscles.
Lateral Rectus = Abducens (CN VI)
Superior Oblique = Trochlear (CN IV)
Medial Rectus, Superior Rectus, Inferior Oblique, Inferior Rectus and Levator Palpebrae Superioris = Oculomotor (CN III)
Where do all the rectus muscles originate?
Common tendinous ring at the apex of the orbit
Where do the rectus muscles insert?
Into the sclera anterior to the globe equator
In what position would the eye have to be to get maximum elevation/depression due to:
a. Superior and Inferior Recti
b. Superior and Inferior Obliques
a. Superior and Inferior Recti- Abducted
b. Superior and Inferior Obliques -Adducted
Explain why this is with respect to the anterior-posterior axis of the eye.
The anterior-posterior axis of the eye is aligned with the axis of the vertical recti when the eye is abducted.
If the eye is adducted, the axes are not aligned and contraction of the vertical recti would cause torsion
Where do oblique muscles attach to the eye?
Into the sclera posterior to the globe equator.
They pull the eye forwards and nasally.
This is because of the pulley system established by the trochlea and the oblique muscles
The oculomotor nerve has two branches. State what each of these branches innervates.
Superior Oculomotor Nerve
- Superior Rectus
- Levator Palpebrae Superioris .
Inferior Oculomotor Nerve
- Inferior Rectus
- Medial Rectus
- Inferior Oblique
- Parasympathetic nerve that causes pupil constriction
How would you test the extraocular muscles?
state for all the muscles
Isolate the muscle to be tested by maximising its action and minimising the action of the other muscles
E.g. to test the superior rectus, make the patient abduct and elevate their eye
Describe and explain what you would see in a patient with 3rd nerve palsy.
Their affected eye would point down and out.
This is because of the unopposed contraction of lateral rectus and superior oblique.
Ptosis – because of the loss of innervation of levator palpebrae superioris.
Pupil dilation – loss of parasympathetic innervation to the eye via CN III
Describe and explain what you would see in a patient with 6th nerve palsy.
When asked the abduct the affected eye, they eye will stop around midline .
This is because the lateral rectus isn’t functioning and can’t abduct the eye .
Diplopia can worsen!
This can lead to blurred vision
What is Hering’s Law of Equal Innervation?
Muscles from both eyes involved in conjugate movement receive equal innervation
What structure in the brainstem acts as a synchronising link between the eyes, allowing paired eye movements?
Medial Longitudinal Fasciculus. an association fibre
What can damage to the right MLF cause?
Internuclear Ophthalmoplegia
E.g. ipsilateral right abduction won’t be accompanied by left adduction (slow).
Could be accompanied by nystagmus on right gaze
What is Sherrington’s Law of Reciprocal Innervation?
Agonist muscles contract while antagonist muscles relax
State a condition in which Sherrington’s Law is violated.
Duane’s Syndrome – congenital absence of abducens (CN VI).
Both lateral and medial recti are innervated by CN III (oculomotor)
What happens to the pupils in the dark?
- increases light sensitivity in the dark by allowing more light into the eye
- pupillary dilatation (as iris radial muscles contract) mediated by sympathetic nerve
What happens if there’s a unilateral afferent defect and unilateral efferent defect?
what are the likely causes of Homonymous hemianopia with macular sparing
if it DOES NOT CROSS the VERTICAL midline then the cause is neurological condition
if the macular sparing DOES NOT CROSS the horizontal midline then its GLAUCOMA
What is optokinetic nystagmus
Smooth pursuit plus Fast phase reset sacchade
what is optokinetic nystagmus reflex and what is it useful for?
Optokinetic Nystagmus Reflex is useful in testing visual acuity in pre-verbal children by observing the presence of nystagmus movement in response to moving grating patterns of various spatial frequencies
Presence of Optokinetic Nystagmus in response to moving grating signifies that the subject has sufficient visual acuity to perceive the grating pattern.
Lack of it suggests a neuro comdition rather than labyrinthine
Name all the directions of eye movement
what is the function of all the eye muscles
Label this
