visual development Flashcards
How did they find out that baby’s vision isn’t developed?
Through usign visual evoked potentails and using gratings and analysing results to reconstruct image.
What leads to ocular dominance shift?
monoocular deprivation
Why babies can’t see?
Not bcse optics.
While rod-dominated peripheral retina of the new-
born appears normal, the all-cone fovea contains
widely spaced and poorly developed cones.
* Visual cortex is not fully developed.
what are the underpinning hebian mechanisms resulting in ocular dominace shift?
LTP: open eye input. LTD:closed eye input and Inhibitory synapses
may become stronger
and/or alter network
properties to enable
LTD
what happens when you suture both eyes?
Few binocualr cells develop. Although receptive fields are not imapcted.
why are there uniform distribution in first 2 weeks?
LGN afferents terminating in layer IV of
striate cortex have markedly
overlapping arbors
process of marking ocular dominance coloumns?
you inject the radioactive amino acid that gets taken
up by the retinal ganglion cells take it up to
the the LGN nucleus.
It goes across the synapse, get taken up by the
postsynaptic cells and the postsynaptic cells.
Then take it right up to the primary visual cortex.
When are ocular domiance columns visible?
Distinct ocular dominance patterns are
evident within about 6 weeks in layer IV
(cat and monkey
how do Geniculocortical axon arbors in layer IV in normal cats
and after monocular deprivation present?
In young: terminal wide, expand over a large region.
In mature: condensed compact
open monoocualr deprivation: terminals broader
closed: thinly sparse.
ocular dominance shift: how and why
- There is competition between the
geniculocortical inputs related to the two eyes for
cortical space. - In the absence of inputs (visual experience)
originating in one eye, the inputs related to the
other eye takes over the cortical space. - Note that it is form vision, not simple
diffuse light, that is essential to establish
normal connectivity. - There are very few changes earlier along
the visual pathway - in the retina and LGN,
except some shrinkage of cells in the
deprived LGN laminae.
ocular domiance shift: when does it occur?
During critical period of close to 1 week in first few weeks of life.
can you reverse ocular dominance shift during critical period?
yes. even for 14 days reversal.
why critical periods don’t last?
Theories about termination of Critical Period:
1. When axonal growth stops… when they lose their
ability to change terminal length.
2. When synaptic transmission has fully matured…from
changes in post-synaptic receptors (glutamate,
NMDA, GABAergic inhibition, etc.)
3. When activity of neuromodulators (norepinephrine,
acetylcholine, etc.) in certain cortical areas decline.
critical periods across vision?
Bionocular vision has varying critical periods across species. In humans 3-4 years. Different visual
functions have
different critical
periods
Is critical period restricted to vision?
- Occurs in other sensory systems too, for example the
auditory system of barn owls (Knudsen, 1999; DeBello
et al., 2001) and cats
during early life. - There is also competition between different sensory
modalities (vision, touch and hearing), similar to
competition between two eyes (Vidyasagar, Nature,1978;
Rauschecker, Trends in Neurosci.,1995): e.g., there is a greater
neuronal pool devoted to auditory and somatosensory processing in a visually deprived animal. - Imprinting: birds can be shown to imprint on any object exposed
to them immediately after birth (Konrad Lorenz: King Solomon’s
Ring) - Language development: E.g., in children rescued from wolves
or from total social isolation?
! Why is there a critical period?
