Viruses of the Hematopoietic System

Question 1

CTFV

Family?

Answer 1

Reoviridae

Question 2

CTFV

genome?

Answer 2

dsRNA segmented

Question 3

What are the two viruses that aren’t enveloped?

Answer 3

CTFV

Parvovirus B19

Question 4

CTFV tropism?

Answer 4

Pro-erytrhoblasts>

RBC

Question 5

CTFV pathology?

Answer 5

Saddlback fever

travel out west

Question 6

Where does CTFV makes it’s viruses?

Answer 6

In cytoplasmic viral factories! This allows it to evade DICER RISC

Question 7

CTFV treatment?

Answer 7

supportive

Question 8

What viruses are part of the herpesviridae family?

Answer 8

CMV- hhv 5
HHV6 and 7
EBV- hhv 4
Karposi’s

Question 9

What is the genome for herpesviruses?

Answer 9

dsDNA

Question 10

What is the tropism for CMV?

Answer 10

Monocytes and macrophages

Question 11

CMV pathologies?

Answer 11

1. CMV infectious mononucleosis: heterophile Ab negative, owls eyes cells
2. Congenital systemic CMV: deafness

Question 12

CMV treatment?

Answer 12

supportive;

ganciclovir for immunocompe pts

Question 13

What is the tropism for HHV-6/7?

Answer 13

CD4 T cells

Question 14

HHV6/7 pathologies?

Answer 14

exanthem subitum (roseola/sixth disease): rash that develops after a fever resolves, nonpruritic rash on trunk, child < 2

heterophile Ab mononucleosis

Question 15

HHV6/7 treatment?

Answer 15

Supportive;

ganciclovir and cidofovir in immunocomp pts

Question 16

EBV tropism? Acute and Latent?

Answer 16

Acute- epithelial cells of oropharynx (lytic)

Latent- B cells

Question 17

EBV pathology?

Answer 17

EBV infectious mono: Heterophile Ab positive

Question 18

What malignancies are associated w/ EBV?

Answer 18

Burkitt
Hodge and non hodge
nasopharyngeal
x-linked lymphoproliferative disorder

Question 19

What is the mut related to x-linked lymphoproliferative disorder?

Answer 19

Mut in SAP adapter–can’t put the breaks on IS

Question 20

How do you treat EBV?

Answer 20

supportive

Question 21

What is the tropism for karposi’s (HHV-8)?

Answer 21

B cells

Question 22

Karposi’s is only seen in what population?

Answer 22

immnocompromised

Karposis
primary effusion
lymphoma
multifocal
castlemans disease

Question 23

What is the treatment for kaposi’s?

Answer 23

ganciclovir
cidofir
foscarnet

Question 24

Parvovirus B19 is better known as what?

Answer 24

5ths disease–slapped cheeks, lacey pattern, fever

Question 25

Parvo B19 genome?

Answer 25

ssDNA

Question 26

Parvo B19 tropism?

Answer 26

ERythroid progenitor cells

Question 27

What is common in pt’s w/ B19 and an underlying anemia?

Answer 27

aplastic crisis

Question 28

Tx for B19?

Answer 28

supportive

Question 29

What two diseases are ssRNA positive?

Answer 29

HTLV

HIV

Question 30

HTLV-1 and 2 tropism?

Answer 30

HTLV-1: CD4

HTLV-2 CD8

Question 31

HTLV pathology?

Answer 31

Actue T cell lylmphoma

Question 32

What does Tax do in actue T cell lymphoma related to HTLV?

Answer 32

it is a viral TF that drives proliferation and blocks apotosis

Question 33

What does HAM/TSP do in HTLV?

Answer 33

Dries inflammation on the spine

Question 34

how do you treat HTLV?

Answer 34

chemo/BMT

Question 35

What is the tropism for HIV?

Answer 35

CD4 T cells, monocytes, macrophages

Question 36

What is the pathology for HIV?

Answer 36

Depletion CD4 T cells allows for opportunisitc infections

Question 37

Tx AIDS?

Answer 37

anti-retroviral agents

Question 38

What viruses effect erythroid progenitor cells?

Answer 38

Parvovirus B 19

Question 39

What virus effects erythroid progenitor cells and RBCs?

Answer 39

CTFV

Question 40

What virus affects monocytes?

Answer 40

CMV

Question 41

What viruses effect B lymphocytes?

Answer 41

EBV

Kaposi’s

Question 42

What viruses effect T lymphocytes?

Answer 42

HHV 6 and 9
HTLV
HIV