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IHO Week 1 > Viruses of the Hematopoietic System > Flashcards

Viruses of the Hematopoietic System Flashcards

1
Q

CTFV

Family?

A

Reoviridae

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2
Q

CTFV

genome?

A

dsRNA segmented

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3
Q

What are the two viruses that aren’t enveloped?

A

CTFV

Parvovirus B19

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4
Q

CTFV tropism?

A

Pro-erytrhoblasts>

RBC

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5
Q

CTFV pathology?

A

Saddlback fever

travel out west

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6
Q

Where does CTFV makes it’s viruses?

A

In cytoplasmic viral factories! This allows it to evade DICER RISC

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7
Q

CTFV treatment?

A

supportive

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8
Q

What viruses are part of the herpesviridae family?

A

CMV- hhv 5
HHV6 and 7
EBV- hhv 4
Karposi’s

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9
Q

What is the genome for herpesviruses?

A

dsDNA

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10
Q

What is the tropism for CMV?

A

Monocytes and macrophages

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11
Q

CMV pathologies?

A
  1. CMV infectious mononucleosis: heterophile Ab negative, owls eyes cells
  2. Congenital systemic CMV: deafness
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12
Q

CMV treatment?

A

supportive;

ganciclovir for immunocompe pts

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13
Q

What is the tropism for HHV-6/7?

A

CD4 T cells

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14
Q

HHV6/7 pathologies?

A

exanthem subitum (roseola/sixth disease): rash that develops after a fever resolves, nonpruritic rash on trunk, child < 2

heterophile Ab mononucleosis

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15
Q

HHV6/7 treatment?

A

Supportive;

ganciclovir and cidofovir in immunocomp pts

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16
Q

EBV tropism? Acute and Latent?

A

Acute- epithelial cells of oropharynx (lytic)

Latent- B cells

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17
Q

EBV pathology?

A

EBV infectious mono: Heterophile Ab positive

18
Q

What malignancies are associated w/ EBV?

A

Burkitt
Hodge and non hodge
nasopharyngeal
x-linked lymphoproliferative disorder

19
Q

What is the mut related to x-linked lymphoproliferative disorder?

A

Mut in SAP adapter–can’t put the breaks on IS

20
Q

How do you treat EBV?

A

supportive

21
Q

What is the tropism for karposi’s (HHV-8)?

A

B cells

22
Q

Karposi’s is only seen in what population?

A

immnocompromised

Karposis
primary effusion
lymphoma
multifocal
castlemans disease
23
Q

What is the treatment for kaposi’s?

A

ganciclovir
cidofir
foscarnet

24
Q

Parvovirus B19 is better known as what?

A

5ths disease–slapped cheeks, lacey pattern, fever

25
Q

Parvo B19 genome?

A

ssDNA

26
Q

Parvo B19 tropism?

A

ERythroid progenitor cells

27
Q

What is common in pt’s w/ B19 and an underlying anemia?

A

aplastic crisis

28
Q

Tx for B19?

A

supportive

29
Q

What two diseases are ssRNA positive?

A

HTLV

HIV

30
Q

HTLV-1 and 2 tropism?

A

HTLV-1: CD4

HTLV-2 CD8

31
Q

HTLV pathology?

A

Actue T cell lylmphoma

32
Q

What does Tax do in actue T cell lymphoma related to HTLV?

A

it is a viral TF that drives proliferation and blocks apotosis

33
Q

What does HAM/TSP do in HTLV?

A

Dries inflammation on the spine

34
Q

how do you treat HTLV?

A

chemo/BMT

35
Q

What is the tropism for HIV?

A

CD4 T cells, monocytes, macrophages

36
Q

What is the pathology for HIV?

A

Depletion CD4 T cells allows for opportunisitc infections

37
Q

Tx AIDS?

A

anti-retroviral agents

38
Q

What viruses effect erythroid progenitor cells?

A

Parvovirus B 19

39
Q

What virus effects erythroid progenitor cells and RBCs?

A

CTFV

40
Q

What virus affects monocytes?

A

CMV

41
Q

What viruses effect B lymphocytes?

A

EBV

Kaposi’s

42
Q

What viruses effect T lymphocytes?

A

HHV 6 and 9
HTLV
HIV

IHO Week 1 (1 decks)

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