Viruses

Question 1

Rotavirus : pathogenesis

Answer 1

• genome consisting of 11 separate segments of double-stranded RNA
• common in children

damages transport mechanism in gut, loss of fluids and electrolytes causes diarrhea
- villous atrophy, flattened, no inflammation/ loss of blood

Question 2

rotavirus: lab diagnosis

Answer 2

feces:
- electron microscopy: cubic symmetry, outer capsid coat, wheel like appearance
- ELISA: detects viral antigens

Question 3

rotavirus: treatment and prevention

Answer 3

ORS

Question 4

Calciviruses (norovirus)

Answer 4

food/ waterborne route, eating shellfish
- chills, headache, myalgia, fever, nausea, abdominal pain, vomiting, diarrhea