Virus Evolution Flashcards
1
Q
Why does HPV 16 cause cancer?
A
E6 and E7 targets P53, apoptosis is inhibited so the cell cycle is perturbed
2
Q
Why do E6 and E7 have so many cellular targets?
A
They have unstructured regions so they are flexible and can fold into a range of conformations and mimic a range of proteins
3
Q
What are the advantages and disadvantages of increasing the capsid size?
A
+
Larger genome can accommodate more useful genes
-
Slower and more complex life-cycle
4
Q
What is ribavirin?
A
Used in combination with interferon-alpha to treat HCV infection, can be mutagenic
5
Q
What mutations slow the rate of polyprotein processing
A
2A mutations
