Virology Flashcards
Flaviviridae
West Nile Virus
Yellow Fever Virus
Dengue Virus
Zika Virus
Tulip Breaking Virus
Potyviridae
non-enveloped viruses
picarnoviridae
ds DNA
ss DNA
ds RNA
papillomaviridae
Ebola nucleocapsid proteins
VP24
VP30
VP35
Poliovirus capsid proteins
VP1
VP2
VP3
VP4
cleaved by 3CD to form 5S protamer
peptide P1
helical symmetry nucleocapsids
measles
TMV- tobacco mosaic virus
TBV - tulip breaking virus
Ebola
VSV - vesiculus somatitis virus
poliovirus entry
when poliovirus binds with the PVR receptor on the host cell membrane
hydrophobic n-terminus of VP1 protein inserts itself onto the cell membrane and VP4 creates a channel for the positive sense RNA genome to go through
VP4 - is buried
polyhedral symmetry capsids
poliovirus
simian 40
HIV-1 receptors and co-receptors
CD4 - main
CCR5 - co
CXCR4 - co
co-receptors are called -chemokine receptors
Poliovirus receptor
PVR
Adenoviruses 2 and 5 receptors
CAR
Integrin
Murine Leukemia virus
cationic amino acid transporter
Human Corona Virus
Amino-peptidase N
Measles virus
CD46
Some Rhinovirus
LDL-receptor
gp1 protein in which envelope
ebola
L protein
ebola rna dependent rna polymerase - viral protein
ebola outbreak 3 cities
guinea
liberia
sierra leonea
countries in africa
what does gapped ds dna also contain
proteins and pieces of RNA
these can be called as remnants of RNA genome and also a protein remains attached to the genome
what can hepatitis B cause
liver damage- sexual contact
rotavirus symptomps
first 5 years of life
gastroenteritis -infant mortality
dehydration main contributor to mortality
fever,abdominal pain diarreha
vertice
face
edge
5 tail to tail
3 head to head
2 head to head
which virus can be defined as Norwalk virus
quasiequivalent
also norwalk virus - non-enveloped - calicirusviridae - winter vomiting
which sugar is sialic acid always linked to - host cell receptor
galactose
what part of what gets cleaved by who in Ebola virus so it can be released from the late endosome?
CHO part of GP1 in Ebola envelope glycoprotein gets cleaved by cathepsins so it can interact with NPC-1 (cholesterol transporter) and get released to the cytoplasm
difference between gp1 and gp2 in ebola
gp1 - binding
gp2 - fusion
west nile virus which city and which city
new york and israel
after viremia what happened
skin rashes - hosts response to viral replications
secondary viremia
delayed in virions in the blood it means transmitting to other parts
early rash
severe rash
papules
ulcer
sex workers in which cities
Zaire and Rwanda
proviral DNA
viral DNA that has been already integrated to the cell genome
where did these 4 spillover events happend to humans
Kinshosa (Zaire)
where Korv a and b both present
koalas in LA
how does cART work
it blocks the activity of viral enzymes
gapped ds DNA
viral DNA dep pol filld the gaps - there are also proteins and RNA pieces and then host dna dep does the transcription
PIC
gets formed in the cytoplasm after the reverse transcription is done- contains viral enzymes integrase etc and goes to the nucleus after the insertion to host genome is done it ceases to exist
Ebola enterance to the host cell
fusion happens at the late endosome membrane - NPC-1 - cathepsins cut the galactose moleules - CHO part of GP1 to allow reaction with NPC-1
gp120 and gp41 in HIV
gp 120 - SU - vp that interacts with the host receptors
gp 41 - TM - fusion protein
camerooon
little n, o , p group cases
