Viral Oncogenes

Question 1

Viral Oncogene Families

Answer 1

Adenovirus, Hepadnavirus, Herpesvirus, Falvivirus, Papillomaviruses, Polyomavirus, Retrovirus

Question 2

Adenovirus (type, Human Tumor, CoFactors, Comments (re malignancy)

Answer 2

Types 2, 5, 12
None
N/A
Experimental model

Question 3

Hepadnavirus (type, Human Tumor, CoFactors, Comments (re malignancy)

Answer 3

Hepatitis B virus (HBV)
Hepatocellular carcinoma (HCC)
Aflatoxin, alcohol, smoking
Causitive

Question 4

Herpesvirus (Type)

Answer 4

1) Epstein-Barr virus (EBV)

2) KSHV (HSV8)

Question 5

Epstein-Barr virus (Virus family, Human Tumors, their relevant cofactors and comments re malignancy)

Answer 5

-Herpesvirus
-Cofactors
EBV-associated malignancies in immunosuppressed individuals (immunodificiency; causative)
-Nasopharyngeal carcinoma (Nitrosamines/genetic; causative)
-Hodgkin’s lymphoma (?; variable association)
-Gastric carcinoma (?; variable association)

Question 6

KSHV (HSV8) (Virus family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 6

• Herpesvirus
• Cofactors:
  
  • Kaposi’s sarcoma (AIDS; causative)
  • Castleman’s disease (?; causative)
  • Primary effusion lymphomas (?; causative)

Question 7

Flavivirus (type, Human Tumor, CoFactors, Comments (re malignancy)

Answer 7

• Hepatitis C virus
• Hepatocellular carcinoma
• Aflatoxin
• Causative

Question 8

Papillomaviruses (types)

Answer 8

• HPV16, -18, -31, -33, -35, -39, and others.

- HPVV5, -8, -17, -20, -47

Question 9

HPV16, -18, -31, -33, -35, -39, and others (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 9

• Papillomaviruses
• Anogenital cancers, some upper airway cancers
• Smoking, oral contraceptives, others
• Causative

Question 10

HPVV5, -8, -17, -20, -47 (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 10

• Papillomaviruses
• Skin cancer
• Genetic disorder (EV), UV, immunosuppression
• Unclear if causative

Question 11

Polyomavirus (Types)

Answer 11

• MCV
• BK
• JC
• SV40

Question 12

MCV (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 12

• Polyomavirus
• Merkel cell cancer
• uv, immunosuppression
• likely causative

Question 13

BK (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 13

• Polyomavirus
• Prostate preneoplastic lesions
• ?
• Unclear if causative

Question 14

JC (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 14

• Polyomavirus
• brain tumors
• ?
• unclear if causative

Question 15

SV40 (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 15

• Polyomavirus
• Mesotheliomas, brain tumors
• ?
• Unlikely causative

Question 16

Retroviruses (Types)

Answer 16

• HTLV-1

- HTLV-2

Question 17

HTLV-1 (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 17

• Retrovirus
• ATL
• Genetic?
• Causative

Question 18

HTLV-2 (Virus Family, Human Tumor, CoFactors, Comments (re malignancy)

Answer 18

• None
• N/a
• Not associated with human malignancy