Viral Infections Flashcards
What are warts?
Benign infections of the skin & mucous membranes caused by HPV
Epidemiology of warts?
- Cutaneous warts common in children and young adults, incidence reduces with age.
- In children genital lesions may result from autoinnoculation from cutaneous lesions
> should raise suspicion of sexual abuse when extensive.
Transmission of infection of warts?
- Genital infection
- by intimate contact with affected individuals. - Non-genital (skin) infection
- Directly: person to person contact
- Indirectly: contaminated surfaces/objects; swimming pools, gyms etc.
Note: Individuals with sub-clinical infection can transmit the virus.
Clinical features of warts and what they depend on?
depend on HPV type and anatomic site of infection.
1. cutaneous lesions: HPV 1,2,3,4 and 10
2. mucosal lesions: HPV 6 and 11
Clinical classification of cutaneous warts?
- Common warts (veruccae vulgaris)
- Palmar-plantar warts
- Flats warts
- Filiform/digitate warts
Describe the appearance of common warts?
appear singly or grouped as rounded papules or nodules with rough, grayish scaly surface.
Location of common warts?
- common on sites prone to trauma but may locate anywhere
- fingers, dorsal surfaces of the hands, knees, elbows - Can also involve the nail
- around nail plate: periungual
- under nail plate: subungual
Common causes of common warts?
HPV 1,2,4, 27, 57, 53
Describe palmar and plantar warts?
- Thick, endophytic, hyperkeratotic papules on the palms, soles and lateral surfaces of hands and feet
- have gently sloping sides with central depression (hence myrmecia [antihill] warts)
- Mosaic warts: coalescence into plaque of superficial plantar warts
- May be extensive & painful when walking due to deep ingrowth
Common causes of palmar and plantar warts?
HPV 1,2,4,27 and 57
Describe filiform/figitate warts?
- Located on the beard area, periorally, alae nasi and around the eyes.
- Manifest as several skin coloured finger-like projections emanating from a narrow base.
Describe flat warts?
- 1 to 4 mm slightly elevated, flat topped papules with minimal scale.
- Commonly located on the hands, arms or face often in a linear array – demonstrating Koebner phenomenon.
- Can be quite resistant to treatment, especially in HIV immune suppresion
Flat warts causes?
HPV 3, 10, 28 and 41
What is epidermodysplasia verucciformis?
- Autosomal recessive inheritance with unique susceptibility to HPV 5 and 8.
- Starting from childhood, widespread flat or minimally scaly lesions resembling P.versicolor
- Always recur after treatment.
- May transform to SCC in sun-exposed areas
Principles of treatment of viral warts?
- No single effective treatment
- Some patients may chose to leave their lesions for spontaneous resolution.
- Decision to treat should be based on individual basis
- Where treatment is opted, aim should be to cure, but control of spread and relief of symptoms may be acceptable.
- Paring the wart where possible to enhance effect of drug.
- If drug used for 6 months without change, consider next level
First line therapy treatment for warts?
- Salicylic acid generally reserve concentration of more than 15 % to plantar and palmar surfaces
- Glutaldehyde 10 % solution or gel 2x daily
- Silver nitrate stick
Second line therapy for warts?
Cryotherapy (avoid its use in peri and subungual)
Third line therapy for warts?
- Immiquimoid
- 5 fluoro uracil
- contact sensitisers
- cimetidine
- levimazole
Surgical treatment of warts?
- currettage
- excision
What is molluscum contagiosum?
- Benign, usually self limiting disease in children (1-5 yrs),
- Rare in adults, but may be present in genital area where it may be transmitted sexually
Cause of molluscum contagiosum?
- Cause: pox virus
- Incubation period: 2- 8 weeks
- Transmission: person to person, autoinnoculation
Clinical features of molluscum contagiosum?
Presents with discrete dome shaped papules with a umbilicated center from which a cheesy plug can be expressed
Common sites of infection for molluscum contagiosum?
face, eyelids, neck axillae, thighs, genital regions
What is eczema molluscum?
eczema and erythematous changes around lesions