Viral hepatitis

Question 1

Viral hepatitis

HAV

Answer 1

only fulminant in 0.1 cases
incubation period of 3-6 wks
febrile illness associated w jaundice and fatigue and loss of appetite
small non enveloped RNA picornavirus
HAV is an icosahedral capsid 27 nm in diameter. The receptor for HAV is HAVcr-1, a membrane glycoprotein that also may serve as a receptor for Ebola .

Question 2

transmission

Answer 2

ingestion of contaminated water and food and is shed in the stool for 2 to 3 weeks before and 1 week after the onset of jaundice.
cytotoxic CD8+ T cells, plays a key role in HAV-mediated hepatocellular injury.
detection by IgM antibody
IgG often lifetime

Question 3

hbv outcomes

Answer 3

asymptomatic. carrier
non progressive acute w recovery and clearance of virus
progressive chronic illness that may cause cirrhosis
fulminant liver disease

Question 4

One-third of the world’s population (2 billion individuals) has been infected with HBV, and 400 million individuals have chronic infections

Answer 4

Approximately 70% of adults with newly acquired HBV have mild or no symptoms and do not develop jaundice.The remaining 30% have nonspecific constitutional symptoms such as anorexia, fever, jaundice, and right upper-quadrant pain