Viral hepatitides Flashcards
RNA picornavirus, transmitted by fecal-oral route (occasionally through food sources or through anal sex)
IgM and IgG antibodies
Does not increase risk of HCC
Hep A
infected blood or body fluids, including vertical transmission from mother to child
‘Ground-glass’ hepatocytes
polyarteritis nodosa
Routinely vaccinated at 2,3,4 months
Hep B
intravenous drug users and patients who received a blood transfusion prior to 1991
Hep C
HBSag then develops new onset of hepatitis symptoms
Needs previous or concurrent Hep B infection
Hep D
faecal-oral route
Does not increase risk of HCC or chronic disease
Dangerous in pregnancy
Hep E
Management of Hep A
Vaccine - dose then booster within a year
MSM
Complications of hep B
Chronic hepatitis - ground glass hepatocytes
HCC
Polyarteritis nodosa
hep B immunisation
At 2,3,4 months
At risk groups - IVDU, sex workers
testing for anti-HBs
- Healthworkers and CKD, 1-4 months
-> 100 good
10-100 - booster
<10 - 3 doses again
Management of hep B
Pegylated interferon alpha
Investigation hep C
Anti HCV antibodies
Complication HepC
Chronic Hep C
Complications of chronic Hep C
rheumatological problems: […], arthritis
eye problems: […] syndrome
[…] (5-20% of those with chronic disease)
[…] […]
[…]: typically type II (mixed monoclonal and polyclonal)
[…] […] […]
[…] glomerulonephritis
rheumatological problems: arthralgia, arthritis
eye problems: Sjogren’s syndrome
cirrhosis (5-20% of those with chronic disease)
hepatocellular cancer
cryoglobulinaemia: typically type II (mixed monoclonal and polyclonal)
porphyria cutanea tarda (PCT): it is increasingly recognised that PCT may develop in patients with hepatitis C, especially if there are other factors such as alcohol abuse
membranoproliferative glomerulonephritis
Management HepC
Protease inhibitors + ribavirin
